Risk of subarachnoid haemorrhage in first degree relatives of patients with subarachnoid haemorrhage: Follow up study based on national registries in Denmark

D Gaist, M Vaeth, I Tsiropoulos, Kaare Christensen, E Corder, Jørn Olsen, H T Sørensen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

OBJECTIVE: To estimate the risk of occurrence of subarachnoid haemorrhage in first degree relatives (parents, siblings, children) of patients with subarachnoid haemorrhage. DESIGN: Population based cohort study using data from the Danish National Discharge Registry and the Central Person Registry. SUBJECTS: Incident cases of subarachnoid haemorrhage admitted to hospital from 1977 to 1995 (9367 patients) and their first degree relatives (14 781). MAIN OUTCOME MEASURES: The incidence rate of subarachnoid haemorrhage was determined for the relatives and compared with that of the entire population, standardised for age, sex, and calendar period. This process was repeated for patients discharged from neurosurgery units, as diagnoses from these wards had high validity (93%). RESULTS: 18 patients had a total of 19 first degree relatives with subarachnoid haemorrhage during the study period, corresponding to a standardised incidence ratio of 2.9 (95% confidence interval 1.9 to 4.6). Patients discharged from neurosurgery wards had a higher standardised incidence ratio (4.5, 2.7 to 7.3). CONCLUSIONS: First degree relatives of patients with subarachnoid haemorrhage have a threefold to fivefold increased risk of subarachnoid haemorrhage compared with the general population.
Original languageEnglish
JournalBMJ - British Medical Journal - Clinical Research Edition
Volume320
Issue number7228
Pages (from-to)141-145
Number of pages4
ISSN0959-8138
DOIs
Publication statusPublished - 2000

Fingerprint

Denmark
Registries
Neurosurgery
Incidence
Population
Siblings
Cohort Studies
Parents
Outcome Assessment (Health Care)
Confidence Intervals

Keywords

  • Adolescent
  • Adult
  • Age of Onset
  • Aged
  • Child
  • Child, Preschool
  • Cohort Studies
  • Denmark
  • Female
  • Follow-Up Studies
  • Humans
  • Incidence
  • Infant
  • Infant, Newborn
  • Male
  • Middle Aged
  • Pedigree
  • Registries
  • Risk Factors
  • Subarachnoid Hemorrhage

Cite this

@article{54d8e1c0ba9711dc9626000ea68e967b,
title = "Risk of subarachnoid haemorrhage in first degree relatives of patients with subarachnoid haemorrhage: Follow up study based on national registries in Denmark",
abstract = "OBJECTIVE: To estimate the risk of occurrence of subarachnoid haemorrhage in first degree relatives (parents, siblings, children) of patients with subarachnoid haemorrhage. DESIGN: Population based cohort study using data from the Danish National Discharge Registry and the Central Person Registry. SUBJECTS: Incident cases of subarachnoid haemorrhage admitted to hospital from 1977 to 1995 (9367 patients) and their first degree relatives (14 781). MAIN OUTCOME MEASURES: The incidence rate of subarachnoid haemorrhage was determined for the relatives and compared with that of the entire population, standardised for age, sex, and calendar period. This process was repeated for patients discharged from neurosurgery units, as diagnoses from these wards had high validity (93{\%}). RESULTS: 18 patients had a total of 19 first degree relatives with subarachnoid haemorrhage during the study period, corresponding to a standardised incidence ratio of 2.9 (95{\%} confidence interval 1.9 to 4.6). Patients discharged from neurosurgery wards had a higher standardised incidence ratio (4.5, 2.7 to 7.3). CONCLUSIONS: First degree relatives of patients with subarachnoid haemorrhage have a threefold to fivefold increased risk of subarachnoid haemorrhage compared with the general population.",
keywords = "Adolescent, Adult, Age of Onset, Aged, Child, Child, Preschool, Cohort Studies, Denmark, Female, Follow-Up Studies, Humans, Incidence, Infant, Infant, Newborn, Male, Middle Aged, Pedigree, Registries, Risk Factors, Subarachnoid Hemorrhage",
author = "D Gaist and M Vaeth and I Tsiropoulos and Kaare Christensen and E Corder and J{\o}rn Olsen and S{\o}rensen, {H T}",
year = "2000",
doi = "10.1136/bmj.320.7228.141",
language = "English",
volume = "320",
pages = "141--145",
journal = "B M J (Clinical Research Edition)",
issn = "0959-8138",
publisher = "B M J Group",
number = "7228",

}

Risk of subarachnoid haemorrhage in first degree relatives of patients with subarachnoid haemorrhage : Follow up study based on national registries in Denmark. / Gaist, D; Vaeth, M; Tsiropoulos, I; Christensen, Kaare; Corder, E; Olsen, Jørn; Sørensen, H T.

In: BMJ - British Medical Journal - Clinical Research Edition, Vol. 320, No. 7228, 2000, p. 141-145.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Risk of subarachnoid haemorrhage in first degree relatives of patients with subarachnoid haemorrhage

T2 - Follow up study based on national registries in Denmark

AU - Gaist, D

AU - Vaeth, M

AU - Tsiropoulos, I

AU - Christensen, Kaare

AU - Corder, E

AU - Olsen, Jørn

AU - Sørensen, H T

PY - 2000

Y1 - 2000

N2 - OBJECTIVE: To estimate the risk of occurrence of subarachnoid haemorrhage in first degree relatives (parents, siblings, children) of patients with subarachnoid haemorrhage. DESIGN: Population based cohort study using data from the Danish National Discharge Registry and the Central Person Registry. SUBJECTS: Incident cases of subarachnoid haemorrhage admitted to hospital from 1977 to 1995 (9367 patients) and their first degree relatives (14 781). MAIN OUTCOME MEASURES: The incidence rate of subarachnoid haemorrhage was determined for the relatives and compared with that of the entire population, standardised for age, sex, and calendar period. This process was repeated for patients discharged from neurosurgery units, as diagnoses from these wards had high validity (93%). RESULTS: 18 patients had a total of 19 first degree relatives with subarachnoid haemorrhage during the study period, corresponding to a standardised incidence ratio of 2.9 (95% confidence interval 1.9 to 4.6). Patients discharged from neurosurgery wards had a higher standardised incidence ratio (4.5, 2.7 to 7.3). CONCLUSIONS: First degree relatives of patients with subarachnoid haemorrhage have a threefold to fivefold increased risk of subarachnoid haemorrhage compared with the general population.

AB - OBJECTIVE: To estimate the risk of occurrence of subarachnoid haemorrhage in first degree relatives (parents, siblings, children) of patients with subarachnoid haemorrhage. DESIGN: Population based cohort study using data from the Danish National Discharge Registry and the Central Person Registry. SUBJECTS: Incident cases of subarachnoid haemorrhage admitted to hospital from 1977 to 1995 (9367 patients) and their first degree relatives (14 781). MAIN OUTCOME MEASURES: The incidence rate of subarachnoid haemorrhage was determined for the relatives and compared with that of the entire population, standardised for age, sex, and calendar period. This process was repeated for patients discharged from neurosurgery units, as diagnoses from these wards had high validity (93%). RESULTS: 18 patients had a total of 19 first degree relatives with subarachnoid haemorrhage during the study period, corresponding to a standardised incidence ratio of 2.9 (95% confidence interval 1.9 to 4.6). Patients discharged from neurosurgery wards had a higher standardised incidence ratio (4.5, 2.7 to 7.3). CONCLUSIONS: First degree relatives of patients with subarachnoid haemorrhage have a threefold to fivefold increased risk of subarachnoid haemorrhage compared with the general population.

KW - Adolescent

KW - Adult

KW - Age of Onset

KW - Aged

KW - Child

KW - Child, Preschool

KW - Cohort Studies

KW - Denmark

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Incidence

KW - Infant

KW - Infant, Newborn

KW - Male

KW - Middle Aged

KW - Pedigree

KW - Registries

KW - Risk Factors

KW - Subarachnoid Hemorrhage

U2 - 10.1136/bmj.320.7228.141

DO - 10.1136/bmj.320.7228.141

M3 - Journal article

C2 - 10634731

VL - 320

SP - 141

EP - 145

JO - B M J (Clinical Research Edition)

JF - B M J (Clinical Research Edition)

SN - 0959-8138

IS - 7228

ER -