Risk factors and prognosis of seizures in adults with community-acquired bacterial meningitis in Denmark: Observational cohort studies

Fredrikke Tove Birgitta Dam Larsen, Christian Thomas Brandt, Lykke Larsen, vibeke Klastrup, Lothar Weise, Jannik Helweg-Larsen, Birgitte Rønde Hansen, Christian Østergaard Andersen, Henrik Nielsen, Jacob Bodilsen, DASGIB study group

Research output: Contribution to journalJournal articleResearchpeer-review

85 Downloads (Pure)

Abstract

Objective To examine predefined risk factors and outcome of seizures in community-acquired bacterial meningitis (CABM). Design Observational cohort studies Setting Denmark Participants In the derivation cohort, we retrospectively included all adults (>15 years of age) with CABM in North Denmark Region from 1998 to 2014 and at Hvidovre and Hillerød hospitals from 2003 to 2014. In the validation cohort, we prospectively included all adults (>18 years of age) with CABM treated at all departments of infectious diseases in Denmark from 2015 to 2017. Primary and secondary outcome measures In the derivation cohort, we used modified Poisson regression to compute adjusted relative risks (RRs) with 95% confidence intervals for predefined risk factors for seizures during CABM as well as for risks of death and unfavourable outcome assessed by the Glasgow Outcome Scale score (1-4). Next, results were validated in the validation cohort. Results In the derivation cohort (n=358), risk factors for seizures at any time were pneumococcal aetiology (RR 1.69, 1.01-2.83) and abnormal cranial imaging (RR 2.27, 1.46-3.53), while the impact of age >65 years and immunocompromise was more uncertain. Examining seizures occurring after admission, risk factors were abnormal cranial imaging (RR 2.23, 1.40-3.54) and immunocompromise (RR 1.59, 1.01-2.50). Seizures at any time were associated with increased risks of in-hospital mortality (RR 1.45, 1.01-2.09) and unfavourable outcome at discharge (RR 1.27, 1.02-1.60). In the validation cohort (n=379), pneumococcal aetiology (RR 1.69, 1.10-2.59) and abnormal cranial imaging (RR 1.68, 1.09-2.59) were confirmed as risk factors for seizures at any time. For seizures occurring after admission, only pneumococcal meningitis (RR 1.92, 1.12-3.29) remained significant. Seizures at any time were also associated with in-hospital mortality (RR 3.26, 1.83-5.80) and unfavourable outcome (RR 1.23, 1.00-1.52) in this cohort. Conclusions Pneumococcal aetiology, immunocompromise and abnormal cranial imaging were risk factors for seizures in CABM. Seizures were strongly associated with mortality and unfavourable outcome.

Original languageEnglish
Article numbere030263
JournalBMJ Open
Volume9
Issue number7
ISSN2044-6055
DOIs
Publication statusPublished - 1. Jul 2019

Keywords

  • Epidemiology
  • Epilepsy

Fingerprint

Dive into the research topics of 'Risk factors and prognosis of seizures in adults with community-acquired bacterial meningitis in Denmark: Observational cohort studies'. Together they form a unique fingerprint.

Cite this