Richness of human gut microbiome correlates with metabolic markers

Emmanuelle Le Chatelier; Trine Nielsen; Junjie Qin; Edi Prifti; Falk Hildebrand; Gwen Falony; Mathieu Almeida; Manimozhiyan Arumugam; Jean-Michel Batto; Sean Kennedy; Pierre Leonard; Junhua Li; Kristoffer Sølvsten Burgdorf; Niels Grarup; Torben Jørgensen; Ivan Brandslund; Henrik Bjørn Nielsen; Agnieszka Juncker; Marcelo Bertalan; Florence Levenez; Nicolas Pons; Simon Rasmussen; Shinichi Sunagawa; Julien Tap; Sebastian Tims; Erwin G Zoetendal; Søren Brunak; Karine Clément; Joël Doré; Michiel Kleerebezem; Karsten Kristiansen; Pierre Renault; Thomas Sicheritz-Ponten; Willem M de Vos; Jean-Daniel Zucker; Jeroen Raes; Torben Hansen; Peer Bork; Jun Wang; S Dusko Ehrlich; Oluf Borbye Pedersen; MetaHIT consortium

doi:10.1038/nature12506

Richness of human gut microbiome correlates with metabolic markers

Emmanuelle Le Chatelier, Trine Nielsen, Junjie Qin, Edi Prifti, Falk Hildebrand, Gwen Falony, Mathieu Almeida, Manimozhiyan Arumugam, Jean-Michel Batto, Sean Kennedy, Pierre Leonard, Junhua Li, Kristoffer Sølvsten Burgdorf, Niels Grarup, Torben Jørgensen, Ivan Brandslund, Henrik Bjørn Nielsen, Agnieszka Juncker, Marcelo Bertalan, Florence LevenezNicolas Pons, Simon Rasmussen, Shinichi Sunagawa, Julien Tap, Sebastian Tims, Erwin G Zoetendal, Søren Brunak, Karine Clément, Joël Doré, Michiel Kleerebezem, Karsten Kristiansen, Pierre Renault, Thomas Sicheritz-Ponten, Willem M de Vos, Jean-Daniel Zucker, Jeroen Raes, Torben Hansen, Peer Bork, Jun Wang, S Dusko Ehrlich, Oluf Borbye Pedersen, MetaHIT consortium

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

We are facing a global metabolic health crisis provoked by an obesity epidemic. Here we report the human gut microbial composition in a population sample of 123 non-obese and 169 obese Danish individuals. We find two groups of individuals that differ by the number of gut microbial genes and thus gut bacterial richness. They contain known and previously unknown bacterial species at different proportions; individuals with a low bacterial richness (23% of the population) are characterized by more marked overall adiposity, insulin resistance and dyslipidaemia and a more pronounced inflammatory phenotype when compared with high bacterial richness individuals. The obese individuals among the lower bacterial richness group also gain more weight over time. Only a few bacterial species are sufficient to distinguish between individuals with high and low bacterial richness, and even between lean and obese participants. Our classifications based on variation in the gut microbiome identify subsets of individuals in the general white adult population who may be at increased risk of progressing to adiposity-associated co-morbidities.

Original language	English
Journal	Nature Communications
Volume	500
Issue number	7464
Pages (from-to)	541-546
ISSN	2041-1723
DOIs	https://doi.org/10.1038/nature12506
Publication status	Published - 2013

Keywords

Adiposity
Adult
Bacteria
Biological Markers
Body Mass Index
Case-Control Studies
Diet
Dyslipidemias
Energy Metabolism
Europe
European Continental Ancestry Group
Female
Gastrointestinal Tract
Genes, Bacterial
Humans
Inflammation
Insulin Resistance
Male
Metagenome
Obesity
Overweight
Phylogeny
Thinness
Weight Gain
Weight Loss

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Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., Almeida, M., Arumugam, M., Batto, J.-M., Kennedy, S., Leonard, P., Li, J., Burgdorf, K. S., Grarup, N., Jørgensen, T., Brandslund, I., Nielsen, H. B., Juncker, A., Bertalan, M., ... MetaHIT consortium (2013). Richness of human gut microbiome correlates with metabolic markers. Nature Communications, 500(7464), 541-546. https://doi.org/10.1038/nature12506

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title = "Richness of human gut microbiome correlates with metabolic markers",

abstract = "We are facing a global metabolic health crisis provoked by an obesity epidemic. Here we report the human gut microbial composition in a population sample of 123 non-obese and 169 obese Danish individuals. We find two groups of individuals that differ by the number of gut microbial genes and thus gut bacterial richness. They contain known and previously unknown bacterial species at different proportions; individuals with a low bacterial richness (23% of the population) are characterized by more marked overall adiposity, insulin resistance and dyslipidaemia and a more pronounced inflammatory phenotype when compared with high bacterial richness individuals. The obese individuals among the lower bacterial richness group also gain more weight over time. Only a few bacterial species are sufficient to distinguish between individuals with high and low bacterial richness, and even between lean and obese participants. Our classifications based on variation in the gut microbiome identify subsets of individuals in the general white adult population who may be at increased risk of progressing to adiposity-associated co-morbidities.",

keywords = "Adiposity, Adult, Bacteria, Biological Markers, Body Mass Index, Case-Control Studies, Diet, Dyslipidemias, Energy Metabolism, Europe, European Continental Ancestry Group, Female, Gastrointestinal Tract, Genes, Bacterial, Humans, Inflammation, Insulin Resistance, Male, Metagenome, Obesity, Overweight, Phylogeny, Thinness, Weight Gain, Weight Loss",

author = "{Le Chatelier}, Emmanuelle and Trine Nielsen and Junjie Qin and Edi Prifti and Falk Hildebrand and Gwen Falony and Mathieu Almeida and Manimozhiyan Arumugam and Jean-Michel Batto and Sean Kennedy and Pierre Leonard and Junhua Li and Burgdorf, {Kristoffer S{\o}lvsten} and Niels Grarup and Torben J{\o}rgensen and Ivan Brandslund and Nielsen, {Henrik Bj{\o}rn} and Agnieszka Juncker and Marcelo Bertalan and Florence Levenez and Nicolas Pons and Simon Rasmussen and Shinichi Sunagawa and Julien Tap and Sebastian Tims and Zoetendal, {Erwin G} and S{\o}ren Brunak and Karine Cl{\'e}ment and Jo{\"e}l Dor{\'e} and Michiel Kleerebezem and Karsten Kristiansen and Pierre Renault and Thomas Sicheritz-Ponten and {de Vos}, {Willem M} and Jean-Daniel Zucker and Jeroen Raes and Torben Hansen and Peer Bork and Jun Wang and Ehrlich, {S Dusko} and Pedersen, {Oluf Borbye} and {MetaHIT consortium}",

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doi = "10.1038/nature12506",

language = "English",

volume = "500",

pages = "541--546",

journal = "Nature Communications",

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Le Chatelier, E, Nielsen, T, Qin, J, Prifti, E, Hildebrand, F, Falony, G, Almeida, M, Arumugam, M, Batto, J-M, Kennedy, S, Leonard, P, Li, J, Burgdorf, KS, Grarup, N, Jørgensen, T, Brandslund, I, Nielsen, HB, Juncker, A, Bertalan, M, Levenez, F, Pons, N, Rasmussen, S, Sunagawa, S, Tap, J, Tims, S, Zoetendal, EG, Brunak, S, Clément, K, Doré, J, Kleerebezem, M, Kristiansen, K, Renault, P, Sicheritz-Ponten, T, de Vos, WM, Zucker, J-D, Raes, J, Hansen, T, Bork, P, Wang, J, Ehrlich, SD, Pedersen, OB & MetaHIT consortium 2013, 'Richness of human gut microbiome correlates with metabolic markers', Nature Communications, vol. 500, no. 7464, pp. 541-546. https://doi.org/10.1038/nature12506

TY - JOUR

T1 - Richness of human gut microbiome correlates with metabolic markers

AU - Le Chatelier, Emmanuelle

AU - Nielsen, Trine

AU - Qin, Junjie

AU - Prifti, Edi

AU - Hildebrand, Falk

AU - Falony, Gwen

AU - Almeida, Mathieu

AU - Arumugam, Manimozhiyan

AU - Batto, Jean-Michel

AU - Kennedy, Sean

AU - Leonard, Pierre

AU - Li, Junhua

AU - Burgdorf, Kristoffer Sølvsten

AU - Grarup, Niels

AU - Jørgensen, Torben

AU - Brandslund, Ivan

AU - Nielsen, Henrik Bjørn

AU - Juncker, Agnieszka

AU - Bertalan, Marcelo

AU - Levenez, Florence

AU - Pons, Nicolas

AU - Rasmussen, Simon

AU - Sunagawa, Shinichi

AU - Tap, Julien

AU - Tims, Sebastian

AU - Zoetendal, Erwin G

AU - Brunak, Søren

AU - Clément, Karine

AU - Doré, Joël

AU - Kleerebezem, Michiel

AU - Kristiansen, Karsten

AU - Renault, Pierre

AU - Sicheritz-Ponten, Thomas

AU - de Vos, Willem M

AU - Zucker, Jean-Daniel

AU - Raes, Jeroen

AU - Hansen, Torben

AU - Bork, Peer

AU - Wang, Jun

AU - Ehrlich, S Dusko

AU - Pedersen, Oluf Borbye

AU - MetaHIT consortium

PY - 2013

Y1 - 2013

N2 - We are facing a global metabolic health crisis provoked by an obesity epidemic. Here we report the human gut microbial composition in a population sample of 123 non-obese and 169 obese Danish individuals. We find two groups of individuals that differ by the number of gut microbial genes and thus gut bacterial richness. They contain known and previously unknown bacterial species at different proportions; individuals with a low bacterial richness (23% of the population) are characterized by more marked overall adiposity, insulin resistance and dyslipidaemia and a more pronounced inflammatory phenotype when compared with high bacterial richness individuals. The obese individuals among the lower bacterial richness group also gain more weight over time. Only a few bacterial species are sufficient to distinguish between individuals with high and low bacterial richness, and even between lean and obese participants. Our classifications based on variation in the gut microbiome identify subsets of individuals in the general white adult population who may be at increased risk of progressing to adiposity-associated co-morbidities.

AB - We are facing a global metabolic health crisis provoked by an obesity epidemic. Here we report the human gut microbial composition in a population sample of 123 non-obese and 169 obese Danish individuals. We find two groups of individuals that differ by the number of gut microbial genes and thus gut bacterial richness. They contain known and previously unknown bacterial species at different proportions; individuals with a low bacterial richness (23% of the population) are characterized by more marked overall adiposity, insulin resistance and dyslipidaemia and a more pronounced inflammatory phenotype when compared with high bacterial richness individuals. The obese individuals among the lower bacterial richness group also gain more weight over time. Only a few bacterial species are sufficient to distinguish between individuals with high and low bacterial richness, and even between lean and obese participants. Our classifications based on variation in the gut microbiome identify subsets of individuals in the general white adult population who may be at increased risk of progressing to adiposity-associated co-morbidities.

KW - Adiposity

KW - Adult

KW - Bacteria

KW - Biological Markers

KW - Body Mass Index

KW - Case-Control Studies

KW - Diet

KW - Dyslipidemias

KW - Energy Metabolism

KW - Europe

KW - European Continental Ancestry Group

KW - Female

KW - Gastrointestinal Tract

KW - Genes, Bacterial

KW - Humans

KW - Inflammation

KW - Insulin Resistance

KW - Male

KW - Metagenome

KW - Obesity

KW - Overweight

KW - Phylogeny

KW - Thinness

KW - Weight Gain

KW - Weight Loss

U2 - 10.1038/nature12506

DO - 10.1038/nature12506

M3 - Journal article

C2 - 23985870

SN - 2041-1723

VL - 500

SP - 541

EP - 546

JO - Nature Communications

JF - Nature Communications

IS - 7464

ER -

Richness of human gut microbiome correlates with metabolic markers

Abstract

Keywords

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