Abstract
Deprescribing aims to address the problem of medication overuse in older adults. There has been an increasing number of systematic reviews of ‘deprescribing’. We aimed to describe the categories of trials included in recent systematic reviews, and to make recommendations for future research. We categorized 122 trials included in eight recent deprescribing systematic reviews into: discontinuation, deprescribing implementation, medication optimisation (including medication initiation) and non-initiation trials. We identified heterogeneity and inconsistency in the categories of trials included in deprescribing systematic reviews. For example, 39 trials (32.0%) involved medication initiation in addition to the deprescribing component. It is now time for international researchers to develop and validate terminology used for trials involving discontinuation/deprescribing of medications, and to provide recommendations for evidence synthesis that will better inform future research, and translation into practice and policy.
| Original language | English |
|---|---|
| Journal | British Journal of Clinical Pharmacology |
| Volume | 89 |
| Issue number | 12 |
| Pages (from-to) | 3758-3764 |
| ISSN | 0306-5251 |
| DOIs | |
| Publication status | Published - Dec 2023 |
Bibliographical note
Publisher Copyright:© 2023 British Pharmacological Society.
Funding
The authors thank Jeremy Grimshaw for providing insights into the categorization of trials and the interpretation of data. AS performed this work during a research stay at the Ottawa Hospital Research Institute, and she was supported by a Mobility Grant from Fondation Mont‐Godinne (2021–2022). ER is supported by an NHMRC Investigator Grant (APP1195460). ER is supported by a United States National Institutes of Health (NIH) grant and has received royalties for co‐authoring a chapter on deprescribing in UpToDate and honorarium from the Society of Hospital Pharmacists of Australia (leading workshops on deprescribing). The authors have no other conflict of interest to disclose in relation to this work. The authors thank Jeremy Grimshaw for providing insights into the categorization of trials and the interpretation of data. AS performed this work during a research stay at the Ottawa Hospital Research Institute, and she was supported by a Mobility Grant from Fondation Mont-Godinne (2021–2022). ER is supported by an NHMRC Investigator Grant (APP1195460).
Keywords
- deprescribing
- deprescriptions (MeSH)
- medication overuse
- systematic review
- Polypharmacy
- Deprescriptions
- Humans
- Systematic Reviews as Topic
- Aged
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