Replication studies in longevity: Puzzling findings in Danish centenarians at the 3'APOB-VNTR locus

O Varcasia, S Garasto, T Rizza, K Andersen-Ranberg, B Jeune, L Bathum, K Andreev, Q Tan, A I Yashin, M Bonafè, C Franceschi, G De Benedictis

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

In Danes we replicated the 3'APOB-VNTR gene/longevity association study previously carried out in Italians, by which the Small alleles (less than 35 repeats) had been identified as frailty alleles for longevity. In Danes, neither genotype nor allele frequencies differed between centenarians and 20-64-year-old subjects. However, when Danish and Italian data were compared, a significant difference (p = 0.0004) was found between the frequencies of Small alleles in youths, which disappeared in centenarians (p = 0.290). Furthermore, the demographic-genetic approach revealed in Danes a significant gene-sex interaction relevant to Long alleles (more than 37 repeats). The different findings in Denmark and Italy suggest that gene/longevity associations are population-specific, and heavily affected by the population-specific genetic and environmental history.
Original languageEnglish
JournalAnnals of Human Genetics
Volume65
Issue numberPt 4
Pages (from-to)371-376
Number of pages5
ISSN0003-4800
DOIs
Publication statusPublished - 1. Jul 2001

Fingerprint

Minisatellite Repeats
Alleles
Population Genetics
Denmark
Italy
History
Population

Keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • Alleles
  • Apolipoproteins B
  • DNA
  • Demography
  • Denmark
  • Female
  • Gene Frequency
  • Genotype
  • Humans
  • Italy
  • Longevity
  • Male
  • Middle Aged
  • Minisatellite Repeats
  • Models, Genetic
  • Polymerase Chain Reaction
  • Risk
  • Sex Characteristics

Cite this

Varcasia, O ; Garasto, S ; Rizza, T ; Andersen-Ranberg, K ; Jeune, B ; Bathum, L ; Andreev, K ; Tan, Q ; Yashin, A I ; Bonafè, M ; Franceschi, C ; De Benedictis, G. / Replication studies in longevity : Puzzling findings in Danish centenarians at the 3'APOB-VNTR locus. In: Annals of Human Genetics. 2001 ; Vol. 65, No. Pt 4. pp. 371-376.
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abstract = "In Danes we replicated the 3'APOB-VNTR gene/longevity association study previously carried out in Italians, by which the Small alleles (less than 35 repeats) had been identified as frailty alleles for longevity. In Danes, neither genotype nor allele frequencies differed between centenarians and 20-64-year-old subjects. However, when Danish and Italian data were compared, a significant difference (p = 0.0004) was found between the frequencies of Small alleles in youths, which disappeared in centenarians (p = 0.290). Furthermore, the demographic-genetic approach revealed in Danes a significant gene-sex interaction relevant to Long alleles (more than 37 repeats). The different findings in Denmark and Italy suggest that gene/longevity associations are population-specific, and heavily affected by the population-specific genetic and environmental history.",
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Varcasia, O, Garasto, S, Rizza, T, Andersen-Ranberg, K, Jeune, B, Bathum, L, Andreev, K, Tan, Q, Yashin, AI, Bonafè, M, Franceschi, C & De Benedictis, G 2001, 'Replication studies in longevity: Puzzling findings in Danish centenarians at the 3'APOB-VNTR locus', Annals of Human Genetics, vol. 65, no. Pt 4, pp. 371-376. https://doi.org/10.1017/S0003480001008715

Replication studies in longevity : Puzzling findings in Danish centenarians at the 3'APOB-VNTR locus. / Varcasia, O; Garasto, S; Rizza, T; Andersen-Ranberg, K; Jeune, B; Bathum, L; Andreev, K; Tan, Q; Yashin, A I; Bonafè, M; Franceschi, C; De Benedictis, G.

In: Annals of Human Genetics, Vol. 65, No. Pt 4, 01.07.2001, p. 371-376.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Replication studies in longevity

T2 - Puzzling findings in Danish centenarians at the 3'APOB-VNTR locus

AU - Varcasia, O

AU - Garasto, S

AU - Rizza, T

AU - Andersen-Ranberg, K

AU - Jeune, B

AU - Bathum, L

AU - Andreev, K

AU - Tan, Q

AU - Yashin, A I

AU - Bonafè, M

AU - Franceschi, C

AU - De Benedictis, G

PY - 2001/7/1

Y1 - 2001/7/1

N2 - In Danes we replicated the 3'APOB-VNTR gene/longevity association study previously carried out in Italians, by which the Small alleles (less than 35 repeats) had been identified as frailty alleles for longevity. In Danes, neither genotype nor allele frequencies differed between centenarians and 20-64-year-old subjects. However, when Danish and Italian data were compared, a significant difference (p = 0.0004) was found between the frequencies of Small alleles in youths, which disappeared in centenarians (p = 0.290). Furthermore, the demographic-genetic approach revealed in Danes a significant gene-sex interaction relevant to Long alleles (more than 37 repeats). The different findings in Denmark and Italy suggest that gene/longevity associations are population-specific, and heavily affected by the population-specific genetic and environmental history.

AB - In Danes we replicated the 3'APOB-VNTR gene/longevity association study previously carried out in Italians, by which the Small alleles (less than 35 repeats) had been identified as frailty alleles for longevity. In Danes, neither genotype nor allele frequencies differed between centenarians and 20-64-year-old subjects. However, when Danish and Italian data were compared, a significant difference (p = 0.0004) was found between the frequencies of Small alleles in youths, which disappeared in centenarians (p = 0.290). Furthermore, the demographic-genetic approach revealed in Danes a significant gene-sex interaction relevant to Long alleles (more than 37 repeats). The different findings in Denmark and Italy suggest that gene/longevity associations are population-specific, and heavily affected by the population-specific genetic and environmental history.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Alleles

KW - Apolipoproteins B

KW - DNA

KW - Demography

KW - Denmark

KW - Female

KW - Gene Frequency

KW - Genotype

KW - Humans

KW - Italy

KW - Longevity

KW - Male

KW - Middle Aged

KW - Minisatellite Repeats

KW - Models, Genetic

KW - Polymerase Chain Reaction

KW - Risk

KW - Sex Characteristics

U2 - 10.1017/S0003480001008715

DO - 10.1017/S0003480001008715

M3 - Journal article

C2 - 11592926

VL - 65

SP - 371

EP - 376

JO - Annals of Human Genetics

JF - Annals of Human Genetics

SN - 0003-4800

IS - Pt 4

ER -