Reference Equations for Simultaneously Measured DLCO and DLNO: How Are Reference Equations Influenced by Age, Sex, and Anthropometric Variables?

Mathias Munkholm Sørensen, Janne Mortensen*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review


To this date, only a few reference equations for the simultaneously measured DLCO and DLNO (DL, CO, NO) method have been published in adults. For children, the number is even less. However, the different reference equations are largely alike. Independent variables for most of the outcomes for the DL, CO, NO method are sex, height, age, and/or age squared. Outcomes increase with increasing height and are generally higher in males than in females. In adults, there seems to be an accelerated loss of diffusing capacity with increasing age. Weight is not an independent variable for any of the outcomes. The possible influence of ethnicity on the outcomes has yet not been investigated.
Original languageEnglish
Title of host publicationStructure-Function Relationships in Various Respiratory Systems : Connecting to the Next Generation
EditorsKazuhiro Yamaguchi
Publication date2020
ISBN (Print)978-981-15-5595-4, 978-981-15-5598-5
ISBN (Electronic)978-981-15-5596-1
Publication statusPublished - 2020
Series Respiratory Disease Series: Diagnostic Tools and Disease Managements


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