Reduction in Short-term Outpatient Consultations After a Campaign With Measles Vaccine in Children Aged 9-59 Months: Substudy Within a Cluster-Randomized Trial

Anshu Varma, Peter Aaby, Sanne Marie Thysen, Aksel Karl Georg Jensen, Ane Bærent Fisker

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

BACKGROUND: We assessed a measles vaccination campaign's potential short-term adverse events.

METHODS: In a cluster-randomized trial assessing a measles vaccination campaign's effect on all-cause mortality and hospital admission among children aged 9-59 months in Guinea-Bissau, children received a measles vaccination (intervention) or a health check-up (control). One month to 2 months later, we visited a subgroup of children to ask mothers/guardians about outpatient consultations since enrollment. In log-binomial models, we estimated the relative risk (RR) of nonaccidental outpatient consultations.

RESULTS: Among 8319 children (4437 intervention/3882 control), 652 nonaccidental outpatient consultations occurred (322 intervention/330 control). The measles vaccination campaign tended to reduce nonaccidental outpatient consultations by 16% (RR, 0.84 [95% confidence interval {CI}, .65-1.11]), especially if caused by respiratory symptoms (RR, 0.68 [95% CI, .42-1.11]). The reduction tended to be larger in children who prior to trial enrollment had a pentavalent vaccination (diphtheria, tetanus, pertussis, hepatitis B, and Haemophilus influenzae type b) as the most recent vaccination (RR, 0.61 [95% CI, .42-.89]) than in children who prior to trial enrollment had a routine measles vaccination as the most recent vaccination (RR, 0.93 [95% CI, .68-1.26]) (P = .04 for interaction).

CONCLUSIONS: In the short term, a measles vaccination campaign seems not to increase nonaccidental outpatient consultations but may reduce them.

CLINICAL TRIALS REGISTRATION: NCT03460002.

Original languageEnglish
JournalPediatric Infectious Diseases Society. Journal
Volume9
Issue number5
Pages (from-to)535-543
ISSN2048-7193
DOIs
Publication statusPublished - 10. Nov 2020

Keywords

  • adverse events
  • beneficial nonspecific-effects
  • campaign
  • children
  • measles vaccine

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