Reconstruction of multicompartment oriented neuronal networks for the study of neurodegenerative diseases

Maéva Vignes*, Bérangère Deleglise, Paul Gougis, Laure Saias, Sebastien Magnifico, Laurent Malaquin, Bernard Brugg, Jean Louis Viovy, Jean Michel Peyrin

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

    Abstract

    Experimental models used to study brain development and degeneration range from whole animal models, which preserve the anatomical structures but greatly limit the experimentation at the cellular level, to dissociated cell culture systems, that allow detailed manipulation of cell phenotype but lack the highly ordered and instructive brain environment. Thus new experimental models are needed to facilitate both individual cell manipulation and brain connectivity reconstruction. Here we present powerful microfluidic cell culture systems that allow us to handle neurons and axons in micron size environments and thus to mimic in vitro the development and/or degeneration of some physiological neuronal pathways.

    Original languageEnglish
    Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
    Number of pages3
    Volume1
    Publication date1. Dec 2010
    Pages43-45
    ISBN (Print)9781618390622
    Publication statusPublished - 1. Dec 2010
    Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands
    Duration: 3. Oct 20107. Oct 2010

    Conference

    Conference14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
    Country/TerritoryNetherlands
    CityGroningen
    Period03/10/201007/10/2010

    Keywords

    • Hippocampus
    • Microfabrication
    • Polarized neuronal connections
    • Synaptic loss

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