Reconstruction of multicompartment oriented neuronal networks for the study of neurodegenerative diseases

Maéva Vignes*, Bérangère Deleglise, Paul Gougis, Laure Saias, Sebastien Magnifico, Laurent Malaquin, Bernard Brugg, Jean Louis Viovy, Jean Michel Peyrin

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

Abstract

Experimental models used to study brain development and degeneration range from whole animal models, which preserve the anatomical structures but greatly limit the experimentation at the cellular level, to dissociated cell culture systems, that allow detailed manipulation of cell phenotype but lack the highly ordered and instructive brain environment. Thus new experimental models are needed to facilitate both individual cell manipulation and brain connectivity reconstruction. Here we present powerful microfluidic cell culture systems that allow us to handle neurons and axons in micron size environments and thus to mimic in vitro the development and/or degeneration of some physiological neuronal pathways.

Original languageEnglish
Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Number of pages3
Volume1
Publication date1. Dec 2010
Pages43-45
ISBN (Print)9781618390622
Publication statusPublished - 1. Dec 2010
Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands
Duration: 3. Oct 20107. Oct 2010

Conference

Conference14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
CountryNetherlands
CityGroningen
Period03/10/201007/10/2010

Fingerprint

Neurodegenerative Diseases
Theoretical Models
Neurons
In Vitro Techniques

Keywords

  • Hippocampus
  • Microfabrication
  • Polarized neuronal connections
  • Synaptic loss

Cite this

Vignes, M., Deleglise, B., Gougis, P., Saias, L., Magnifico, S., Malaquin, L., ... Peyrin, J. M. (2010). Reconstruction of multicompartment oriented neuronal networks for the study of neurodegenerative diseases. In 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 (Vol. 1, pp. 43-45)
Vignes, Maéva ; Deleglise, Bérangère ; Gougis, Paul ; Saias, Laure ; Magnifico, Sebastien ; Malaquin, Laurent ; Brugg, Bernard ; Viovy, Jean Louis ; Peyrin, Jean Michel. / Reconstruction of multicompartment oriented neuronal networks for the study of neurodegenerative diseases. 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. Vol. 1 2010. pp. 43-45
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Vignes, M, Deleglise, B, Gougis, P, Saias, L, Magnifico, S, Malaquin, L, Brugg, B, Viovy, JL & Peyrin, JM 2010, Reconstruction of multicompartment oriented neuronal networks for the study of neurodegenerative diseases. in 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. vol. 1, pp. 43-45, 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010, Groningen, Netherlands, 03/10/2010.

Reconstruction of multicompartment oriented neuronal networks for the study of neurodegenerative diseases. / Vignes, Maéva; Deleglise, Bérangère; Gougis, Paul; Saias, Laure; Magnifico, Sebastien; Malaquin, Laurent; Brugg, Bernard; Viovy, Jean Louis; Peyrin, Jean Michel.

14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. Vol. 1 2010. p. 43-45.

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

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T1 - Reconstruction of multicompartment oriented neuronal networks for the study of neurodegenerative diseases

AU - Vignes, Maéva

AU - Deleglise, Bérangère

AU - Gougis, Paul

AU - Saias, Laure

AU - Magnifico, Sebastien

AU - Malaquin, Laurent

AU - Brugg, Bernard

AU - Viovy, Jean Louis

AU - Peyrin, Jean Michel

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KW - Polarized neuronal connections

KW - Synaptic loss

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Vignes M, Deleglise B, Gougis P, Saias L, Magnifico S, Malaquin L et al. Reconstruction of multicompartment oriented neuronal networks for the study of neurodegenerative diseases. In 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. Vol. 1. 2010. p. 43-45