Recognition of stapled histone H3K4me3 peptides by epigenetic reader proteins

Peter Betlem, Marijn N. Maas, Jim Middelburg, Bas J. G. E. Pieters, Jasmin Mecinović*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review


The flexible N-terminal histone tails are a subject of numerous posttranslational modifications, including methylation. We report development of stapled histone peptides bearing trimethyllysine as ligands for epigenetic reader proteins. Stronger or weaker binding affinities have been observed for stapled histone peptides relative to linear histones, indicating that selectivity towards reader proteins can be achieved.
Original languageEnglish
JournalChemical Communications
Pages (from-to)12196-12199
Publication statusPublished - 2022


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