Reciprocal expression of the endocytic protein HIP1R and its repressor FOXP1 predicts outcome in R-CHOP-treated diffuse large B-cell lymphoma patients

K K Wong; D M Gascoyne; P J Brown; E J Soilleux; C Snell; H Chen; L Lyne; C H Lawrie; R D Gascoyne; L M Pedersen; M B Møller; K Pulford; D Murphy; T M Green; A H Banham

doi:10.1038/leu.2013.224

Reciprocal expression of the endocytic protein HIP1R and its repressor FOXP1 predicts outcome in R-CHOP-treated diffuse large B-cell lymphoma patients

K K Wong, D M Gascoyne, P J Brown, E J Soilleux, C Snell, H Chen, L Lyne, C H Lawrie, R D Gascoyne, L M Pedersen, M B Møller, K Pulford, D Murphy, T M Green, A H Banham

KI, OUH, Research unit of Pathology (Odense)

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

We previously identified autoantibodies to the endocytic-associated protein Huntingtin-interacting protein 1-related (HIP1R) in diffuse large B-cell lymphoma (DLBCL) patients. HIP1R regulates internalization of cell surface receptors via endocytosis, a process relevant to many therapeutic strategies including CD20 targeting with rituximab. In this study, we characterized HIP1R expression patterns, investigated a mechanism of transcriptional regulation and its clinical relevance in DLBCL patients treated with immunochemotherapy (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone, R-CHOP). HIP1R was preferentially expressed in germinal center B-cell-like DLBCL (P

Original language	English
Journal	Leukemia
Volume	28
Issue number	2
Pages (from-to)	362-372
Number of pages	11
ISSN	0887-6924
DOIs	https://doi.org/10.1038/leu.2013.224
Publication status	Published - Feb 2014

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10.1038/leu.2013.224

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Wong, K. K., Gascoyne, D. M., Brown, P. J., Soilleux, E. J., Snell, C., Chen, H., Lyne, L., Lawrie, C. H., Gascoyne, R. D., Pedersen, L. M., Møller, M. B., Pulford, K., Murphy, D., Green, T. M., & Banham, A. H. (2014). Reciprocal expression of the endocytic protein HIP1R and its repressor FOXP1 predicts outcome in R-CHOP-treated diffuse large B-cell lymphoma patients. Leukemia, 28(2), 362-372. https://doi.org/10.1038/leu.2013.224

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title = "Reciprocal expression of the endocytic protein HIP1R and its repressor FOXP1 predicts outcome in R-CHOP-treated diffuse large B-cell lymphoma patients",

abstract = "We previously identified autoantibodies to the endocytic-associated protein Huntingtin-interacting protein 1-related (HIP1R) in diffuse large B-cell lymphoma (DLBCL) patients. HIP1R regulates internalization of cell surface receptors via endocytosis, a process relevant to many therapeutic strategies including CD20 targeting with rituximab. In this study, we characterized HIP1R expression patterns, investigated a mechanism of transcriptional regulation and its clinical relevance in DLBCL patients treated with immunochemotherapy (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone, R-CHOP). HIP1R was preferentially expressed in germinal center B-cell-like DLBCL (P",

author = "Wong, {K K} and Gascoyne, {D M} and Brown, {P J} and Soilleux, {E J} and C Snell and H Chen and L Lyne and Lawrie, {C H} and Gascoyne, {R D} and Pedersen, {L M} and M{\o}ller, {M B} and K Pulford and D Murphy and Green, {T M} and Banham, {A H}",

year = "2014",

month = feb,

doi = "10.1038/leu.2013.224",

language = "English",

volume = "28",

pages = "362--372",

journal = "Leukemia",

issn = "0887-6924",

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Wong, KK, Gascoyne, DM, Brown, PJ, Soilleux, EJ, Snell, C, Chen, H, Lyne, L, Lawrie, CH, Gascoyne, RD, Pedersen, LM, Møller, MB, Pulford, K, Murphy, D, Green, TM & Banham, AH 2014, 'Reciprocal expression of the endocytic protein HIP1R and its repressor FOXP1 predicts outcome in R-CHOP-treated diffuse large B-cell lymphoma patients', Leukemia, vol. 28, no. 2, pp. 362-372. https://doi.org/10.1038/leu.2013.224

TY - JOUR

T1 - Reciprocal expression of the endocytic protein HIP1R and its repressor FOXP1 predicts outcome in R-CHOP-treated diffuse large B-cell lymphoma patients

AU - Wong, K K

AU - Gascoyne, D M

AU - Brown, P J

AU - Soilleux, E J

AU - Snell, C

AU - Chen, H

AU - Lyne, L

AU - Lawrie, C H

AU - Gascoyne, R D

AU - Pedersen, L M

AU - Møller, M B

AU - Pulford, K

AU - Murphy, D

AU - Green, T M

AU - Banham, A H

PY - 2014/2

Y1 - 2014/2

N2 - We previously identified autoantibodies to the endocytic-associated protein Huntingtin-interacting protein 1-related (HIP1R) in diffuse large B-cell lymphoma (DLBCL) patients. HIP1R regulates internalization of cell surface receptors via endocytosis, a process relevant to many therapeutic strategies including CD20 targeting with rituximab. In this study, we characterized HIP1R expression patterns, investigated a mechanism of transcriptional regulation and its clinical relevance in DLBCL patients treated with immunochemotherapy (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone, R-CHOP). HIP1R was preferentially expressed in germinal center B-cell-like DLBCL (P

AB - We previously identified autoantibodies to the endocytic-associated protein Huntingtin-interacting protein 1-related (HIP1R) in diffuse large B-cell lymphoma (DLBCL) patients. HIP1R regulates internalization of cell surface receptors via endocytosis, a process relevant to many therapeutic strategies including CD20 targeting with rituximab. In this study, we characterized HIP1R expression patterns, investigated a mechanism of transcriptional regulation and its clinical relevance in DLBCL patients treated with immunochemotherapy (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone, R-CHOP). HIP1R was preferentially expressed in germinal center B-cell-like DLBCL (P

U2 - 10.1038/leu.2013.224

DO - 10.1038/leu.2013.224

M3 - Journal article

C2 - 23884370

SN - 0887-6924

VL - 28

SP - 362

EP - 372

JO - Leukemia

JF - Leukemia

IS - 2

ER -

Reciprocal expression of the endocytic protein HIP1R and its repressor FOXP1 predicts outcome in R-CHOP-treated diffuse large B-cell lymphoma patients

Abstract

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