Real-life data patterns of C-reactive protein and albumin level trajectories around bacteremia

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Abstract

AIM: To assess trajectory patterns of C-reactive protein (CRP) and plasma albumin (PA) levels around bacteremia.

PATIENTS & METHODS: Population-based study, 2418 community-acquired bacteremia patients, CRP and PA specimens from 30 days before through 30 days after bacteremia (day 0). A pattern was based on specimen occurring or not in days -30/-1, 0, 1/7 or 8/30. Mean daily CRP and PA levels on day -30/30 were computed for pattern subgroups.

RESULTS & CONCLUSION: Mean CRP rose on day -5 and reached its peak on day 1. Mean steady PA on day -30/0 declined abruptly on day 1, increasing slowly thereafter. Trajectories did not differ between subgroups. We conclude that longitudinal analysis results can be extrapolated to all community-acquired bacteremia patients.

Original languageEnglish
JournalBiomarkers in Medicine
Volume12
Issue number11
Pages (from-to)1251–1259
ISSN1752-0363
DOIs
Publication statusPublished - 30. Nov 2018

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Serum Albumin
C-Reactive Protein
Albumins
Trajectories
Population

Keywords

  • Bacteremia
  • C-reactive protein
  • Community-acquisition
  • Daily mean level trajectories
  • Plasma albumin

Cite this

@article{53462203d10747a19ca896f9cd4f2783,
title = "Real-life data patterns of C-reactive protein and albumin level trajectories around bacteremia",
abstract = "AIM: To assess trajectory patterns of C-reactive protein (CRP) and plasma albumin (PA) levels around bacteremia.PATIENTS & METHODS: Population-based study, 2418 community-acquired bacteremia patients, CRP and PA specimens from 30 days before through 30 days after bacteremia (day 0). A pattern was based on specimen occurring or not in days -30/-1, 0, 1/7 or 8/30. Mean daily CRP and PA levels on day -30/30 were computed for pattern subgroups.RESULTS & CONCLUSION: Mean CRP rose on day -5 and reached its peak on day 1. Mean steady PA on day -30/0 declined abruptly on day 1, increasing slowly thereafter. Trajectories did not differ between subgroups. We conclude that longitudinal analysis results can be extrapolated to all community-acquired bacteremia patients.",
keywords = "Bacteremia, C-reactive protein, Community-acquisition, Daily mean level trajectories, Plasma albumin",
author = "Gradel, {Kim Oren} and Pedro P{\'o}voa and Vinholt, {Pernille Just} and Bjarne Magnussen and Court Pedersen and Jensen, {Th{\o}ger Gorm} and Kolmos, {Hans J{\o}rn} and Lassen, {Annmarie Touborg}",
year = "2018",
month = "11",
day = "30",
doi = "10.2217/bmm-2018-0043",
language = "English",
volume = "12",
pages = "1251–1259",
journal = "Biomarkers in Medicine",
issn = "1752-0363",
publisher = "Future Medicine Ltd.",
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}

Real-life data patterns of C-reactive protein and albumin level trajectories around bacteremia. / Gradel, Kim Oren; Póvoa, Pedro; Vinholt, Pernille Just; Magnussen, Bjarne; Pedersen, Court; Jensen, Thøger Gorm; Kolmos, Hans Jørn; Lassen, Annmarie Touborg.

In: Biomarkers in Medicine, Vol. 12, No. 11, 30.11.2018, p. 1251–1259.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Real-life data patterns of C-reactive protein and albumin level trajectories around bacteremia

AU - Gradel, Kim Oren

AU - Póvoa, Pedro

AU - Vinholt, Pernille Just

AU - Magnussen, Bjarne

AU - Pedersen, Court

AU - Jensen, Thøger Gorm

AU - Kolmos, Hans Jørn

AU - Lassen, Annmarie Touborg

PY - 2018/11/30

Y1 - 2018/11/30

N2 - AIM: To assess trajectory patterns of C-reactive protein (CRP) and plasma albumin (PA) levels around bacteremia.PATIENTS & METHODS: Population-based study, 2418 community-acquired bacteremia patients, CRP and PA specimens from 30 days before through 30 days after bacteremia (day 0). A pattern was based on specimen occurring or not in days -30/-1, 0, 1/7 or 8/30. Mean daily CRP and PA levels on day -30/30 were computed for pattern subgroups.RESULTS & CONCLUSION: Mean CRP rose on day -5 and reached its peak on day 1. Mean steady PA on day -30/0 declined abruptly on day 1, increasing slowly thereafter. Trajectories did not differ between subgroups. We conclude that longitudinal analysis results can be extrapolated to all community-acquired bacteremia patients.

AB - AIM: To assess trajectory patterns of C-reactive protein (CRP) and plasma albumin (PA) levels around bacteremia.PATIENTS & METHODS: Population-based study, 2418 community-acquired bacteremia patients, CRP and PA specimens from 30 days before through 30 days after bacteremia (day 0). A pattern was based on specimen occurring or not in days -30/-1, 0, 1/7 or 8/30. Mean daily CRP and PA levels on day -30/30 were computed for pattern subgroups.RESULTS & CONCLUSION: Mean CRP rose on day -5 and reached its peak on day 1. Mean steady PA on day -30/0 declined abruptly on day 1, increasing slowly thereafter. Trajectories did not differ between subgroups. We conclude that longitudinal analysis results can be extrapolated to all community-acquired bacteremia patients.

KW - Bacteremia

KW - C-reactive protein

KW - Community-acquisition

KW - Daily mean level trajectories

KW - Plasma albumin

U2 - 10.2217/bmm-2018-0043

DO - 10.2217/bmm-2018-0043

M3 - Journal article

C2 - 30499693

VL - 12

SP - 1251

EP - 1259

JO - Biomarkers in Medicine

JF - Biomarkers in Medicine

SN - 1752-0363

IS - 11

ER -