QuickSOFA is an independent predictor of 30-day mortality among patients admitted to an emergency department with suspected or documented infection

Osama Bin Abdullah, Johannes Grand, Astha Sijapati, Petrine Nimskov

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Abstract

Background. Definitions and clinical criteria for sepsis have been revised in 2016. A simple bedside score (‘qSOFA’, for quick Sequential [Sepsis-Related] Organ Failure Assessment) has been proposed, which incorporates hypotension (systolic blood pressure ≤100mmHg), altered mental status and respiratory rate ≥ 22/min: the presence of at least two of these criteria has been associated with poor outcomes typical of sepsis. The aim of this study was to evaluate qSOFA as a predictor of 30-day mortality in a model with other predictors of death among patients admitted to a single-center emergency department (ED). Methods. A historical cohort study among prospectively registered patients with suspected or documented infection. The admission period was from 1 November 2013 to 31 October 2014. Baseline clinical data and data for survival were obtained from a standard sepsis admission form, the patient records and The Danish Civil Registration System. Logistic regression analysis was used to adjust for potential confounders and to determine whether the predictive factors for death in the crude analyses were independently associated with 30-day mortality. Results. A total of 434 patients were included in the study. Fifty-seven (13.1%; 95% confidence interval [CI] 9.9-16.3%) patients died during the first 30 days. Among several potential confounders tested in the model we found that age (odds ratio [OR] 1.29; 95% CI 1.03-1.61), Charlson Comorbidity Score ≥ 3 (OR 3.83; 95% CI 1.41-10.37), qSOFA score ≥2 (OR 4.78; 95% CI 2.09-10.91) and lactate values (lactate values < 2.0 as reference) within the interval 2.00-3.99 (OR 2.21; 95% CI 1.06-4.62) and lactate values ≥ 4.0 (OR 3.97; 95% CI 1.44-2,92) were associated with 30-day mortality. Conclusion. qSOFA can be helpful to identify infectious patients in an ED with increased risk of 30-day mortality.
Original languageEnglish
Publication date24. Nov 2016
Publication statusPublished - 24. Nov 2016
EventDanish Emergency Medicine Conference 7 - København, Denmark
Duration: 24. Nov 201625. Nov 2016

Conference

ConferenceDanish Emergency Medicine Conference 7
CountryDenmark
CityKøbenhavn
Period24/11/201625/11/2016

Cite this

Bin Abdullah, O., Grand, J., Sijapati, A., & Nimskov, P. (2016). QuickSOFA is an independent predictor of 30-day mortality among patients admitted to an emergency department with suspected or documented infection. Poster session presented at Danish Emergency Medicine Conference 7, København, Denmark.
Bin Abdullah, Osama ; Grand, Johannes ; Sijapati, Astha ; Nimskov, Petrine. / QuickSOFA is an independent predictor of 30-day mortality among patients admitted to an emergency department with suspected or documented infection. Poster session presented at Danish Emergency Medicine Conference 7, København, Denmark.
@conference{5349eb446d0b474995baee4f2ec4e9e8,
title = "QuickSOFA is an independent predictor of 30-day mortality among patients admitted to an emergency department with suspected or documented infection",
abstract = "Background. Definitions and clinical criteria for sepsis have been revised in 2016. A simple bedside score (‘qSOFA’, for quick Sequential [Sepsis-Related] Organ Failure Assessment) has been proposed, which incorporates hypotension (systolic blood pressure ≤100mmHg), altered mental status and respiratory rate ≥ 22/min: the presence of at least two of these criteria has been associated with poor outcomes typical of sepsis. The aim of this study was to evaluate qSOFA as a predictor of 30-day mortality in a model with other predictors of death among patients admitted to a single-center emergency department (ED). Methods. A historical cohort study among prospectively registered patients with suspected or documented infection. The admission period was from 1 November 2013 to 31 October 2014. Baseline clinical data and data for survival were obtained from a standard sepsis admission form, the patient records and The Danish Civil Registration System. Logistic regression analysis was used to adjust for potential confounders and to determine whether the predictive factors for death in the crude analyses were independently associated with 30-day mortality. Results. A total of 434 patients were included in the study. Fifty-seven (13.1{\%}; 95{\%} confidence interval [CI] 9.9-16.3{\%}) patients died during the first 30 days. Among several potential confounders tested in the model we found that age (odds ratio [OR] 1.29; 95{\%} CI 1.03-1.61), Charlson Comorbidity Score ≥ 3 (OR 3.83; 95{\%} CI 1.41-10.37), qSOFA score ≥2 (OR 4.78; 95{\%} CI 2.09-10.91) and lactate values (lactate values < 2.0 as reference) within the interval 2.00-3.99 (OR 2.21; 95{\%} CI 1.06-4.62) and lactate values ≥ 4.0 (OR 3.97; 95{\%} CI 1.44-2,92) were associated with 30-day mortality. Conclusion. qSOFA can be helpful to identify infectious patients in an ED with increased risk of 30-day mortality.",
author = "Nielsen, {Finn Erland} and {Bin Abdullah}, Osama and Johannes Grand and Astha Sijapati and Petrine Nimskov",
year = "2016",
month = "11",
day = "24",
language = "English",
note = "null ; Conference date: 24-11-2016 Through 25-11-2016",

}

Bin Abdullah, O, Grand, J, Sijapati, A & Nimskov, P 2016, 'QuickSOFA is an independent predictor of 30-day mortality among patients admitted to an emergency department with suspected or documented infection', Danish Emergency Medicine Conference 7, København, Denmark, 24/11/2016 - 25/11/2016.

QuickSOFA is an independent predictor of 30-day mortality among patients admitted to an emergency department with suspected or documented infection. / Bin Abdullah, Osama; Grand, Johannes; Sijapati, Astha; Nimskov, Petrine.

2016. Poster session presented at Danish Emergency Medicine Conference 7, København, Denmark.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

TY - CONF

T1 - QuickSOFA is an independent predictor of 30-day mortality among patients admitted to an emergency department with suspected or documented infection

AU - Nielsen, Finn Erland

AU - Bin Abdullah, Osama

AU - Grand, Johannes

AU - Sijapati, Astha

AU - Nimskov, Petrine

PY - 2016/11/24

Y1 - 2016/11/24

N2 - Background. Definitions and clinical criteria for sepsis have been revised in 2016. A simple bedside score (‘qSOFA’, for quick Sequential [Sepsis-Related] Organ Failure Assessment) has been proposed, which incorporates hypotension (systolic blood pressure ≤100mmHg), altered mental status and respiratory rate ≥ 22/min: the presence of at least two of these criteria has been associated with poor outcomes typical of sepsis. The aim of this study was to evaluate qSOFA as a predictor of 30-day mortality in a model with other predictors of death among patients admitted to a single-center emergency department (ED). Methods. A historical cohort study among prospectively registered patients with suspected or documented infection. The admission period was from 1 November 2013 to 31 October 2014. Baseline clinical data and data for survival were obtained from a standard sepsis admission form, the patient records and The Danish Civil Registration System. Logistic regression analysis was used to adjust for potential confounders and to determine whether the predictive factors for death in the crude analyses were independently associated with 30-day mortality. Results. A total of 434 patients were included in the study. Fifty-seven (13.1%; 95% confidence interval [CI] 9.9-16.3%) patients died during the first 30 days. Among several potential confounders tested in the model we found that age (odds ratio [OR] 1.29; 95% CI 1.03-1.61), Charlson Comorbidity Score ≥ 3 (OR 3.83; 95% CI 1.41-10.37), qSOFA score ≥2 (OR 4.78; 95% CI 2.09-10.91) and lactate values (lactate values < 2.0 as reference) within the interval 2.00-3.99 (OR 2.21; 95% CI 1.06-4.62) and lactate values ≥ 4.0 (OR 3.97; 95% CI 1.44-2,92) were associated with 30-day mortality. Conclusion. qSOFA can be helpful to identify infectious patients in an ED with increased risk of 30-day mortality.

AB - Background. Definitions and clinical criteria for sepsis have been revised in 2016. A simple bedside score (‘qSOFA’, for quick Sequential [Sepsis-Related] Organ Failure Assessment) has been proposed, which incorporates hypotension (systolic blood pressure ≤100mmHg), altered mental status and respiratory rate ≥ 22/min: the presence of at least two of these criteria has been associated with poor outcomes typical of sepsis. The aim of this study was to evaluate qSOFA as a predictor of 30-day mortality in a model with other predictors of death among patients admitted to a single-center emergency department (ED). Methods. A historical cohort study among prospectively registered patients with suspected or documented infection. The admission period was from 1 November 2013 to 31 October 2014. Baseline clinical data and data for survival were obtained from a standard sepsis admission form, the patient records and The Danish Civil Registration System. Logistic regression analysis was used to adjust for potential confounders and to determine whether the predictive factors for death in the crude analyses were independently associated with 30-day mortality. Results. A total of 434 patients were included in the study. Fifty-seven (13.1%; 95% confidence interval [CI] 9.9-16.3%) patients died during the first 30 days. Among several potential confounders tested in the model we found that age (odds ratio [OR] 1.29; 95% CI 1.03-1.61), Charlson Comorbidity Score ≥ 3 (OR 3.83; 95% CI 1.41-10.37), qSOFA score ≥2 (OR 4.78; 95% CI 2.09-10.91) and lactate values (lactate values < 2.0 as reference) within the interval 2.00-3.99 (OR 2.21; 95% CI 1.06-4.62) and lactate values ≥ 4.0 (OR 3.97; 95% CI 1.44-2,92) were associated with 30-day mortality. Conclusion. qSOFA can be helpful to identify infectious patients in an ED with increased risk of 30-day mortality.

M3 - Poster

ER -

Bin Abdullah O, Grand J, Sijapati A, Nimskov P. QuickSOFA is an independent predictor of 30-day mortality among patients admitted to an emergency department with suspected or documented infection. 2016. Poster session presented at Danish Emergency Medicine Conference 7, København, Denmark.