Quantitative surface topography assessment of directly compressed and roller compacted tablet cores using photometric stereo image analysis

Morten Allesø*, Per Holm, Jens Michael Carstensen, René Holm

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Surface topography, in the context of surface smoothness/roughness, was investigated by the use of an image analysis technique, MultiRay™, related to photometric stereo, on different tablet batches manufactured either by direct compression or roller compaction. In the present study, oblique illumination of the tablet (darkfield) was considered and the area of cracks and pores in the surface was used as a measure of tablet surface topography; the higher a value, the rougher the surface. The investigations demonstrated a high precision of the proposed technique, which was able to rapidly (within milliseconds) and quantitatively measure the obtained surface topography of the produced tablets. Compaction history, in the form of applied roll force and tablet punch pressure, was also reflected in the measured smoothness of the tablet surfaces. Generally it was found that a higher degree of plastic deformation of the microcrystalline cellulose resulted in a smoother tablet surface. This altogether demonstrated that the technique provides the pharmaceutical developer with a reliable, quantitative response parameter for visual appearance of solid dosage forms, which may be used for process and ultimately product optimization.

Original languageEnglish
JournalEuropean Journal of Pharmaceutical Sciences
Volume87
Pages (from-to)79-87
ISSN0928-0987
DOIs
Publication statusPublished - 25. May 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2015 Elsevier B.V. All rights reserved.

Keywords

  • Microcrystalline cellulose
  • MultiRay™ image analysis
  • Powder compaction
  • Roller compaction
  • Surface roughness
  • Surface topography
  • Tablets

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