Quantitative Sensory Testing and PET/CT  Scanning in Assessment of Surgical Outcome  for Lumbar Disc Herniation

Christian C. Støttrup

doi:10.21996/q6me-0e62

Quantitative Sensory Testing and PET/CT Scanning in Assessment of Surgical Outcome for Lumbar Disc Herniation

Christian C. Støttrup^*

^*Corresponding author for this work

Research output: Thesis › Ph.D. thesis

35 Downloads (Pure)

Abstract

This PhD thesis examines the consequences of prolonged duration of preoperative pain, both in regards of clinical outcome of surgery and whether hypersensitization of pain perception occurs. A large retrospective cohort study including more than 2,000 patients found inferior clinical outcomes of surgical treatment in patients with delayed surgical intervention. Hypersensitivity to pain and experimental stimuli may occur in patients with lumbar disc herniation, however, no clinical importance or usefulness of such tests were detected. Unilateral pain in patients with LDH was found to be associated with increased glucose metabolism in the contralateral thalamus, suggestinga central role of thalamus in chronic pain perception.

Original language	English
Awarding Institution	University of Southern Denmark
Supervisors/Advisors	Andersen, Mikkel Østerheden, Principal supervisor O`Neill, Søren, Co-supervisor Rousing, Rikke, Co-supervisor Høilund-Carlsen, Poul, Co-supervisor
Publisher	Syddansk Universitet. Det Sundhedsvidenskabelige Fakultet
DOIs	https://doi.org/10.21996/q6me-0e62
Publication status	Published - Feb 2020

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10.21996/q6me-0e62

Christian_Støttrup_PhD_ThesisFinal published version, 1.4 MB

2 Journal article

"Visualization" of pain using cerebral 18F-FDG PET/CT following surgical treatment of lumbar disc herniation
Støttrup, C. C., Mortensen, C. H., Piri, R., Khosravi, M., Newberg, A., Andersen, M. Ø., Alavi, A., Grupe, P. & Høilund-Carlsen, P. F., Feb 2023, In: European Spine Journal. 32, 2, p. 555-561
Research output: Contribution to journal › Journal article › Research › peer-review

Open Access
File
49 Downloads (Pure)
Increasing reoperation rates and inferior outcome with prolonged symptom duration in lumbar disc herniation surgery: A prospective cohort study
Støttrup, C. C., Andresen, A. K., Carreon, L. & Andersen, M. Ø., Sept 2019, In: The Spine Journal. 19, 9, p. 1463-1469
Research output: Contribution to journal › Journal article › Research › peer-review

Open Access
File
142 Downloads (Pure)

Cite this

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abstract = "This PhD thesis examines the consequences of prolonged duration of preoperative pain, both in regards of clinical outcome of surgery and whether hypersensitization of pain perception occurs. A large retrospective cohort study including more than 2,000 patients found inferior clinical outcomes of surgical treatment in patients with delayed surgical intervention. Hypersensitivity to pain and experimental stimuli may occur in patients with lumbar disc herniation, however, no clinical importance or usefulness of such tests were detected. Unilateral pain in patients with LDH was found to be associated with increased glucose metabolism in the contralateral thalamus, suggestinga central role of thalamus in chronic pain perception.",

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AB - This PhD thesis examines the consequences of prolonged duration of preoperative pain, both in regards of clinical outcome of surgery and whether hypersensitization of pain perception occurs. A large retrospective cohort study including more than 2,000 patients found inferior clinical outcomes of surgical treatment in patients with delayed surgical intervention. Hypersensitivity to pain and experimental stimuli may occur in patients with lumbar disc herniation, however, no clinical importance or usefulness of such tests were detected. Unilateral pain in patients with LDH was found to be associated with increased glucose metabolism in the contralateral thalamus, suggestinga central role of thalamus in chronic pain perception.

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ER -

Quantitative Sensory Testing and PET/CT Scanning in Assessment of Surgical Outcome for Lumbar Disc Herniation

Abstract

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Related research output

"Visualization" of pain using cerebral 18F-FDG PET/CT following surgical treatment of lumbar disc herniation

Increasing reoperation rates and inferior outcome with prolonged symptom duration in lumbar disc herniation surgery: A prospective cohort study

Cite this