Quantitative Sensory Testing and PET/CT Scanning in Assessment of Surgical Outcome for Lumbar Disc Herniation

Christian C. Støttrup*

*Corresponding author for this work

Research output: ThesisPh.D. thesis

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Abstract

This PhD thesis examines the consequences of prolonged duration of preoperative pain, both in regards of clinical outcome of surgery and whether hypersensitization of pain perception occurs. A large retrospective cohort study including more than 2,000 patients found inferior clinical outcomes of surgical treatment in patients with delayed surgical intervention. Hypersensitivity to pain and experimental stimuli may occur in patients with lumbar disc herniation, however, no clinical importance or usefulness of such tests were detected. Unilateral pain in patients with LDH was found to be associated with increased glucose metabolism in the contralateral thalamus, suggestinga central role of thalamus in chronic pain perception.
Original languageEnglish
Awarding Institution
  • University of Southern Denmark
Supervisors/Advisors
  • Andersen, Mikkel Østerheden, Principal supervisor
  • O`Neill, Søren, Co-supervisor
  • Rousing, Rikke, Co-supervisor
  • Høilund-Carlsen, Poul, Co-supervisor
Publisher
DOIs
Publication statusPublished - Feb 2020

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