Quantitative imaging for radiotherapy purposes

Oliver Gurney-Champion, Faisal Mahmood, Marcel van Schie, Robert Julian, Ben George, Marielle Phillipens, Uulke van der Heide, Daniela Thorwarth, Kathrine Redalen

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Quantitative imaging biomarkers show great potential for use in radiotherapy. Quantitative images based on microscopic tissue properties and tissue function can be used to improve contouring of the radiotherapy targets. Furthermore, quantitative imaging biomarkers might be used to predict treatment response for several treatment regimens and hence be used as a tool for treatment stratification, either to determine which treatment modality is most promising or to determine patient-specific radiation dose. Finally, patient-specific radiation doses can be further tailored to a tissue/voxel specific radiation dose when quantitative imaging is used for dose painting. In this review, published standards, guidelines and recommendations on quantitative imaging assessment using CT, PET and MRI are discussed. Furthermore, critical issues regarding the use of quantitative imaging for radiation oncology purposes and resultant pending research topics are identified.

Original languageEnglish
JournalRadiotherapy & Oncology
Pages (from-to)66-75
Publication statusPublished - May 2020


  • Biomarkers
  • Multimodal imaging
  • Multiparametric magnetic resonance imaging
  • Positron-emission tomography
  • Radiotherapy
  • Review
  • Tumor


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