Quantifying the Relationship Between Curvature and Electric Potential in Lipid Bilayers

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    Abstract

    Cellular membranes mediate vital cellular processes by being subject to curvature and transmembrane electrical potentials. Here we build upon the existing theory for flexoelectricity in liquid crystals to quantify the coupling between lipid bilayer curvature and membrane potentials. Using molecular dynamics simulations, we show that head group dipole moments, the lateral pressure profile across the bilayer and spontaneous curvature all systematically change with increasing membrane potentials. In particu- lar, there is a linear dependence between the bending moment (the product of bending rigidity and spontaneous curvature) and the applied membrane potentials. We show that biologically relevant membrane potentials can induce biologically relevant curva- tures corresponding to radii of around 500nm. The implications of flexoelectricity in lipid bilayers are thus likely to be of considerable consequence both in biology and in model lipid bilayer systems.

    Original languageEnglish
    JournalThe Journal of Physical Chemistry Part B
    Volume120
    Issue number21
    Pages (from-to)4812-4817
    ISSN1520-6106
    DOIs
    Publication statusPublished - 2016

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