Abstract
Gene amplification of HER2 (human epidermal growth factor receptor 2) is a well-known phenomenon in various cancers. However, little is known about the mechanism of the gene amplification phenomenon itself. Autoantibodies to cellular receptors have been described in several cancer types. We hypothesised that autoantibodies against HER2 might have a stimulatory capacity and could be the cause of the HER2 gene amplification phenomenon. To investigate this, we developed a test for the detection of autoantibodies against HER2 in serum (S-HER2Ab).
| Original language | English |
|---|---|
| Journal | Clinical Chemistry and Laboratory Medicine |
| Volume | 49 |
| Issue number | 5 |
| Pages (from-to) | 877-83 |
| Number of pages | 7 |
| ISSN | 1434-6621 |
| DOIs | |
| Publication status | Published - 2011 |
Keywords
- Adult
- Aged
- Aged, 80 and over
- Autoantibodies
- Blood Chemical Analysis
- Blotting, Western
- Breast Neoplasms
- Electrophoresis, Polyacrylamide Gel
- Female
- Gene Amplification
- Humans
- Limit of Detection
- Middle Aged
- Receptor, erbB-2
- Reference Standards
- Reproducibility of Results
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