Quality of life in chronic inflammatory demyelinating polyneuropathy patients treated with subcutaneous immunoglobulin

Anne Kathrine Ryltoft, Ali Al-Zuhairy, Søren H. Sindrup, Henning Andersen, Lars K. Markvardsen*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Background: Subcutaneous immunoglobulin (SCIG) is effective treatment of chronic inflammatory demyelinating polyneuropathy (CIDP). Quality of life (QoL) increases following switch from intravenous administration to SCIG, but its correlation with clinical functioning is sparsely studied. Aims of the study: The aim of this study is to evaluate the correlation between QoL and clinical functioning in CIDP patients treated with SCIG. Methods: Danish patients with CIDP with a disease duration <10 years and currently treated with SCIG were eligible for inclusion. QoL was assessed with EQ-5D-5L and disability by the Overall Disability Sum Score (ODSS) and Rasch-built Overall Disability Scale (RODS). Gait performance was evaluated by a 40-meter-walk test (40-MWT) and a 6-spot-step test (6-SST) along with assessment of muscle strength (Medical Research Council score [MRC]). Correlations between QoL and the measured scores were calculated. Results: Of 92 eligible patients, 44 were included. QoL on the visual analogue scale (VAS) was 65% (range: 15-90) of the level of healthy controls (P =.03) and correlated to impaired gait function by 40-MWT and 6-SST. QoL correlated to RODS and ODSS, whereas there was no correlation with the MRC score. Conclusions: In SCIG treated CIDP patients QoL is reduced and correlates to gait performance and disability.

Original languageEnglish
JournalActa Neurologica Scandinavica
Issue number6
Pages (from-to)637-640
Publication statusPublished - 1. Dec 2020


  • chronic inflammatory demyelinating polyneuropathy
  • quality of life
  • subcutaneous immunoglobulin
  • Disability Evaluation
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/psychology
  • Immunization, Passive/methods
  • Cross-Sectional Studies
  • Gait Disorders, Neurologic/etiology
  • Humans
  • Middle Aged
  • Male
  • Treatment Outcome
  • Immunoglobulins/administration & dosage
  • Young Adult
  • Injections, Subcutaneous
  • Aged, 80 and over
  • Quality of Life
  • Adult
  • Female
  • Aged
  • Muscle Strength


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