Quality of life, depression and anxiety in patients with a subcutaneous versus transvenous defibrillator system

EFFORTLESS Investigators

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Background: Use of the subcutaneous implantable defibrillator (S-ICD) has increased because the device received US Food and Drug Administration approval in 2012, but we still know little about whether the quality of life (QoL) of patients with an S-ICD versus a transvenous ICD (TV-ICD) is comparable. We compared S-ICD patients with TV-ICD patients on QoL, depression, and anxiety up to 12 months’ follow-up. Methods: A matched cohort of S-ICD (N = 167) and TV-ICD patients (N = 167) completed measures on QoL, depression, anxiety, and personality at baseline, 3, 6, and 12 months post implant. Data were analyzed using multivariable modeling with repeated measures. Results: In adjusted analyses, we found no statistically significant differences between cohorts on physical and mental QoL and depression (all Ps >.05), while S-ICD patients reported lower anxiety than TV-ICD patients (P = 0.0007). Both cohorts experienced improvements in physical and mental QoL and symptoms of depression and anxiety over time (all Ps <.001), primarily between implant and 3 months. These improvements were similar for both cohorts with respect to physical and mental QoL and anxiety (Ps >.05), while S-ICD patients experienced greater reductions in depressive symptoms (P =.0317). Conclusion: The QoL and depression levels were similar in patients with an S-ICD and a TV-ICD up to 12 months’ follow-up, while S-ICD patients reported lower anxiety levels and a greater reduction in depression over time as compared to TV-ICD patients. This knowledge may be important for patients and clinicians, if the indication for implantation allows both the S-ICD and the TV-ICD, making a choice possible.

Original languageEnglish
JournalPacing and Clinical Electrophysiology
Volume42
Issue number12
Pages (from-to)1541-1551
ISSN0147-8389
DOIs
Publication statusPublished - Dec 2019

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Quality of Life
Depression
Drug Approval
Implantable Defibrillators
Food
Equipment and Supplies

Bibliographical note

This article is protected by copyright. All rights reserved.

Keywords

  • anxiety
  • depression
  • implantable cardioverter defibrillator
  • quality of life

Cite this

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title = "Quality of life, depression and anxiety in patients with a subcutaneous versus transvenous defibrillator system",
abstract = "Background: Use of the subcutaneous implantable defibrillator (S-ICD) has increased because the device received US Food and Drug Administration approval in 2012, but we still know little about whether the quality of life (QoL) of patients with an S-ICD versus a transvenous ICD (TV-ICD) is comparable. We compared S-ICD patients with TV-ICD patients on QoL, depression, and anxiety up to 12 months’ follow-up. Methods: A matched cohort of S-ICD (N = 167) and TV-ICD patients (N = 167) completed measures on QoL, depression, anxiety, and personality at baseline, 3, 6, and 12 months post implant. Data were analyzed using multivariable modeling with repeated measures. Results: In adjusted analyses, we found no statistically significant differences between cohorts on physical and mental QoL and depression (all Ps >.05), while S-ICD patients reported lower anxiety than TV-ICD patients (P = 0.0007). Both cohorts experienced improvements in physical and mental QoL and symptoms of depression and anxiety over time (all Ps <.001), primarily between implant and 3 months. These improvements were similar for both cohorts with respect to physical and mental QoL and anxiety (Ps >.05), while S-ICD patients experienced greater reductions in depressive symptoms (P =.0317). Conclusion: The QoL and depression levels were similar in patients with an S-ICD and a TV-ICD up to 12 months’ follow-up, while S-ICD patients reported lower anxiety levels and a greater reduction in depression over time as compared to TV-ICD patients. This knowledge may be important for patients and clinicians, if the indication for implantation allows both the S-ICD and the TV-ICD, making a choice possible.",
keywords = "anxiety, depression, implantable cardioverter defibrillator, quality of life",
author = "Pedersen, {Susanne S} and Nathan Carter and Craig Barr and Marcoen Scholten and Lambiase, {Pier D} and Lucas Boersma and Johansen, {Jens Brock} and Theuns, {Dominic A M J} and {EFFORTLESS Investigators}",
note = "This article is protected by copyright. All rights reserved.",
year = "2019",
month = "12",
doi = "10.1111/pace.13828",
language = "English",
volume = "42",
pages = "1541--1551",
journal = "Pacing and Clinical Electrophysiology",
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Quality of life, depression and anxiety in patients with a subcutaneous versus transvenous defibrillator system. / EFFORTLESS Investigators.

In: Pacing and Clinical Electrophysiology, Vol. 42, No. 12, 12.2019, p. 1541-1551.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Quality of life, depression and anxiety in patients with a subcutaneous versus transvenous defibrillator system

AU - Pedersen, Susanne S

AU - Carter, Nathan

AU - Barr, Craig

AU - Scholten, Marcoen

AU - Lambiase, Pier D

AU - Boersma, Lucas

AU - Johansen, Jens Brock

AU - Theuns, Dominic A M J

AU - EFFORTLESS Investigators

N1 - This article is protected by copyright. All rights reserved.

PY - 2019/12

Y1 - 2019/12

N2 - Background: Use of the subcutaneous implantable defibrillator (S-ICD) has increased because the device received US Food and Drug Administration approval in 2012, but we still know little about whether the quality of life (QoL) of patients with an S-ICD versus a transvenous ICD (TV-ICD) is comparable. We compared S-ICD patients with TV-ICD patients on QoL, depression, and anxiety up to 12 months’ follow-up. Methods: A matched cohort of S-ICD (N = 167) and TV-ICD patients (N = 167) completed measures on QoL, depression, anxiety, and personality at baseline, 3, 6, and 12 months post implant. Data were analyzed using multivariable modeling with repeated measures. Results: In adjusted analyses, we found no statistically significant differences between cohorts on physical and mental QoL and depression (all Ps >.05), while S-ICD patients reported lower anxiety than TV-ICD patients (P = 0.0007). Both cohorts experienced improvements in physical and mental QoL and symptoms of depression and anxiety over time (all Ps <.001), primarily between implant and 3 months. These improvements were similar for both cohorts with respect to physical and mental QoL and anxiety (Ps >.05), while S-ICD patients experienced greater reductions in depressive symptoms (P =.0317). Conclusion: The QoL and depression levels were similar in patients with an S-ICD and a TV-ICD up to 12 months’ follow-up, while S-ICD patients reported lower anxiety levels and a greater reduction in depression over time as compared to TV-ICD patients. This knowledge may be important for patients and clinicians, if the indication for implantation allows both the S-ICD and the TV-ICD, making a choice possible.

AB - Background: Use of the subcutaneous implantable defibrillator (S-ICD) has increased because the device received US Food and Drug Administration approval in 2012, but we still know little about whether the quality of life (QoL) of patients with an S-ICD versus a transvenous ICD (TV-ICD) is comparable. We compared S-ICD patients with TV-ICD patients on QoL, depression, and anxiety up to 12 months’ follow-up. Methods: A matched cohort of S-ICD (N = 167) and TV-ICD patients (N = 167) completed measures on QoL, depression, anxiety, and personality at baseline, 3, 6, and 12 months post implant. Data were analyzed using multivariable modeling with repeated measures. Results: In adjusted analyses, we found no statistically significant differences between cohorts on physical and mental QoL and depression (all Ps >.05), while S-ICD patients reported lower anxiety than TV-ICD patients (P = 0.0007). Both cohorts experienced improvements in physical and mental QoL and symptoms of depression and anxiety over time (all Ps <.001), primarily between implant and 3 months. These improvements were similar for both cohorts with respect to physical and mental QoL and anxiety (Ps >.05), while S-ICD patients experienced greater reductions in depressive symptoms (P =.0317). Conclusion: The QoL and depression levels were similar in patients with an S-ICD and a TV-ICD up to 12 months’ follow-up, while S-ICD patients reported lower anxiety levels and a greater reduction in depression over time as compared to TV-ICD patients. This knowledge may be important for patients and clinicians, if the indication for implantation allows both the S-ICD and the TV-ICD, making a choice possible.

KW - anxiety

KW - depression

KW - implantable cardioverter defibrillator

KW - quality of life

U2 - 10.1111/pace.13828

DO - 10.1111/pace.13828

M3 - Journal article

C2 - 31677279

VL - 42

SP - 1541

EP - 1551

JO - Pacing and Clinical Electrophysiology

JF - Pacing and Clinical Electrophysiology

SN - 0147-8389

IS - 12

ER -