Quality of life after Uphold™ Vaginal Support System surgery for apical pelvic organ prolapse-A prospective multicenter study

Päivi Rahkola-Soisalo; Daniel Altman; Christian Falconer; Edward Morcos; Martin Rudnicki; Tomi S Mikkola

doi:10.1016/j.ejogrb.2016.11.011

Quality of life after Uphold™ Vaginal Support System surgery for apical pelvic organ prolapse-A prospective multicenter study

Päivi Rahkola-Soisalo, Daniel Altman, Christian Falconer, Edward Morcos, Martin Rudnicki, Tomi S Mikkola

KI, OUH, Research unit of Gynaecology and Obstetrics

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

OBJECTIVE: To study the effects on quality of life in women operated for apical pelvic organ prolapse using the Vaginal Uphold™ System.

STUDY DESIGN: In this prospective cohort study, women (n=207) with symptomatic apical prolapse, with or without cystocele, were operated using the Uphold™ Vaginal Support System. Follow-up for quality of life was performed at 12 months after surgery, and assessed by the PFDI-20, and PFIQ-7, and sexual function by the PISQ-12. We used odds ratios (ORs) with 95% confidence intervals (CIs) for outcome association analyses using logistic regression.

RESULTS: At one-year follow-up majority of women experienced an overall postoperative improvement in quality of life (p<0.001). One year after surgery Uphold™ operation alone increased the risk for prolapse related bother as compared to Uphold™ combined with anterior colporraphy (POP-IQ-7; OR 2.1; 95% CI 1.01-4.3). The frequency of dyspareunia decreased postoperatively (p=0.004), however, after one-year, overall sexual function deteriorated significantly (p<0.001). The worsening in sexual function scores was mainly attributed to the partner related domain, whereas the behavioral-emotive and physical domains showed no significant changes.

CONCLUSION: Apical prolapse repair using Uphold™ improved quality of life among our patients but worsened overall sexual function postoperatively.

Original language	English
Journal	European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume	208
Pages (from-to)	86-90
ISSN	0301-2115
DOIs	https://doi.org/10.1016/j.ejogrb.2016.11.011
Publication status	Published - 1. Jan 2017

Keywords

Adult
Aged
Aged, 80 and over
Cohort Studies
Cystocele
Female
Follow-Up Studies
Humans
Middle Aged
Operative Time
Patient Satisfaction
Pelvic Floor
Pelvic Organ Prolapse
Postoperative Complications
Prospective Studies
Quality of Life
Risk Factors
Scandinavian and Nordic Countries
Self Report
Severity of Illness Index
Sexual Dysfunction, Physiological
Surgical Mesh
Journal Article
Multicenter Study
Pelvic organ prolapse
Transvaginal mesh
Quality of life
Uterine prolapse

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@article{8b8d45922ccd452d9a28c82c28fa38bf,

title = "Quality of life after Uphold{\texttrademark} Vaginal Support System surgery for apical pelvic organ prolapse-A prospective multicenter study",

abstract = "OBJECTIVE: To study the effects on quality of life in women operated for apical pelvic organ prolapse using the Vaginal Uphold{\texttrademark} System.STUDY DESIGN: In this prospective cohort study, women (n=207) with symptomatic apical prolapse, with or without cystocele, were operated using the Uphold{\texttrademark} Vaginal Support System. Follow-up for quality of life was performed at 12 months after surgery, and assessed by the PFDI-20, and PFIQ-7, and sexual function by the PISQ-12. We used odds ratios (ORs) with 95% confidence intervals (CIs) for outcome association analyses using logistic regression.RESULTS: At one-year follow-up majority of women experienced an overall postoperative improvement in quality of life (p<0.001). One year after surgery Uphold{\texttrademark} operation alone increased the risk for prolapse related bother as compared to Uphold{\texttrademark} combined with anterior colporraphy (POP-IQ-7; OR 2.1; 95% CI 1.01-4.3). The frequency of dyspareunia decreased postoperatively (p=0.004), however, after one-year, overall sexual function deteriorated significantly (p<0.001). The worsening in sexual function scores was mainly attributed to the partner related domain, whereas the behavioral-emotive and physical domains showed no significant changes.CONCLUSION: Apical prolapse repair using Uphold{\texttrademark} improved quality of life among our patients but worsened overall sexual function postoperatively.",

keywords = "Adult, Aged, Aged, 80 and over, Cohort Studies, Cystocele, Female, Follow-Up Studies, Humans, Middle Aged, Operative Time, Patient Satisfaction, Pelvic Floor, Pelvic Organ Prolapse, Postoperative Complications, Prospective Studies, Quality of Life, Risk Factors, Scandinavian and Nordic Countries, Self Report, Severity of Illness Index, Sexual Dysfunction, Physiological, Surgical Mesh, Journal Article, Multicenter Study, Pelvic organ prolapse, Transvaginal mesh, Quality of life, Uterine prolapse",

author = "P{\"a}ivi Rahkola-Soisalo and Daniel Altman and Christian Falconer and Edward Morcos and Martin Rudnicki and Mikkola, {Tomi S}",

year = "2017",

month = jan,

day = "1",

doi = "10.1016/j.ejogrb.2016.11.011",

language = "English",

volume = "208",

pages = "86--90",

journal = "European Journal of Obstetrics & Gynecology and Reproductive Biology",

issn = "0301-2115",

publisher = "Elsevier",

}

Quality of life after Uphold™ Vaginal Support System surgery for apical pelvic organ prolapse-A prospective multicenter study. / Rahkola-Soisalo, Päivi; Altman, Daniel; Falconer, Christian et al.
In: European Journal of Obstetrics & Gynecology and Reproductive Biology, Vol. 208, 01.01.2017, p. 86-90.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - Quality of life after Uphold™ Vaginal Support System surgery for apical pelvic organ prolapse-A prospective multicenter study

AU - Rahkola-Soisalo, Päivi

AU - Altman, Daniel

AU - Falconer, Christian

AU - Morcos, Edward

AU - Rudnicki, Martin

AU - Mikkola, Tomi S

PY - 2017/1/1

Y1 - 2017/1/1

N2 - OBJECTIVE: To study the effects on quality of life in women operated for apical pelvic organ prolapse using the Vaginal Uphold™ System.STUDY DESIGN: In this prospective cohort study, women (n=207) with symptomatic apical prolapse, with or without cystocele, were operated using the Uphold™ Vaginal Support System. Follow-up for quality of life was performed at 12 months after surgery, and assessed by the PFDI-20, and PFIQ-7, and sexual function by the PISQ-12. We used odds ratios (ORs) with 95% confidence intervals (CIs) for outcome association analyses using logistic regression.RESULTS: At one-year follow-up majority of women experienced an overall postoperative improvement in quality of life (p<0.001). One year after surgery Uphold™ operation alone increased the risk for prolapse related bother as compared to Uphold™ combined with anterior colporraphy (POP-IQ-7; OR 2.1; 95% CI 1.01-4.3). The frequency of dyspareunia decreased postoperatively (p=0.004), however, after one-year, overall sexual function deteriorated significantly (p<0.001). The worsening in sexual function scores was mainly attributed to the partner related domain, whereas the behavioral-emotive and physical domains showed no significant changes.CONCLUSION: Apical prolapse repair using Uphold™ improved quality of life among our patients but worsened overall sexual function postoperatively.

AB - OBJECTIVE: To study the effects on quality of life in women operated for apical pelvic organ prolapse using the Vaginal Uphold™ System.STUDY DESIGN: In this prospective cohort study, women (n=207) with symptomatic apical prolapse, with or without cystocele, were operated using the Uphold™ Vaginal Support System. Follow-up for quality of life was performed at 12 months after surgery, and assessed by the PFDI-20, and PFIQ-7, and sexual function by the PISQ-12. We used odds ratios (ORs) with 95% confidence intervals (CIs) for outcome association analyses using logistic regression.RESULTS: At one-year follow-up majority of women experienced an overall postoperative improvement in quality of life (p<0.001). One year after surgery Uphold™ operation alone increased the risk for prolapse related bother as compared to Uphold™ combined with anterior colporraphy (POP-IQ-7; OR 2.1; 95% CI 1.01-4.3). The frequency of dyspareunia decreased postoperatively (p=0.004), however, after one-year, overall sexual function deteriorated significantly (p<0.001). The worsening in sexual function scores was mainly attributed to the partner related domain, whereas the behavioral-emotive and physical domains showed no significant changes.CONCLUSION: Apical prolapse repair using Uphold™ improved quality of life among our patients but worsened overall sexual function postoperatively.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Cohort Studies

KW - Cystocele

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Middle Aged

KW - Operative Time

KW - Patient Satisfaction

KW - Pelvic Floor

KW - Pelvic Organ Prolapse

KW - Postoperative Complications

KW - Prospective Studies

KW - Quality of Life

KW - Risk Factors

KW - Scandinavian and Nordic Countries

KW - Self Report

KW - Severity of Illness Index

KW - Sexual Dysfunction, Physiological

KW - Surgical Mesh

KW - Journal Article

KW - Multicenter Study

KW - Pelvic organ prolapse

KW - Transvaginal mesh

KW - Quality of life

KW - Uterine prolapse

U2 - 10.1016/j.ejogrb.2016.11.011

DO - 10.1016/j.ejogrb.2016.11.011

M3 - Journal article

C2 - 27894034

SN - 0301-2115

VL - 208

SP - 86

EP - 90

JO - European Journal of Obstetrics & Gynecology and Reproductive Biology

JF - European Journal of Obstetrics & Gynecology and Reproductive Biology

ER -

Quality of life after Uphold™ Vaginal Support System surgery for apical pelvic organ prolapse-A prospective multicenter study

Abstract

Keywords

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