PTR2/POT/NPF transporters: what makes them tick?

Bala K. Prabhala, Moazur Rahman, Hussam H. Nour-eldin, Flemming Steen Jørgensen, Osman Mirza*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Abstract

PTR2/POT/NPF are a family of primarily proton coupled transporters that belong to the major facilitator super family and are found across most kingdoms of life. They are involved in uptake of nutrients, hormones, ions and several orally administered drug molecules. A wealth of structural and functional data is available for this family; the similarity between the protein structural features have been discussed and investigated in detail on several occasions, however there are no reports on the unification of substrate information. In order to fill this gap, we have collected information about substrates across the entire PTR2/POT/NPF family in order to provide key insights into what makes a molecule a substrate and whether there are common features among confirmed substrates. This review will be of particular interest for researchers in the field trying to probe the mechanisms responsible for the different selectivity of these transporters at a molecular resolution, and to design novel substrates.

Original languageEnglish
Title of host publicationAdvances in Protein Chemistry and Structural Biology
EditorsRossen Donev
Volume123
PublisherAcademic Press
Publication date2021
Pages219-240
Chapter10
ISBN (Print)9780128220870
DOIs
Publication statusPublished - 2021
SeriesAdvances in Protein Chemistry and Structural Biology
ISSN1876-1623

Keywords

  • NPF
  • POTS
  • Protein structure and mechanism
  • PTR2
  • Transporters

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