Psychiatric disorders as risk factors for the development of type 2 diabetes mellitus: an umbrella review protocol

Nanna Lindekilde, Giesje Nefs, Jan Erik Henriksen, Mathias Lasgaard, Miranda Schram, Katrine Rubin, Femke Rutters, Mika Kivimaki, Frans Pouwer

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Abstract

INTRODUCTION: Numerous longitudinal studies, systematic reviews and meta-analyses have examined psychiatric disorders as risk factors for the development of type 2 diabetes mellitus. A more comprehensive overview of the area is warranted to summarise current evidence and discuss strengths and weaknesses to guide future research.

AIM: The aim of this umbrella review is to determine whether and to what extent different psychiatric disorders are associated with the development of type 2 diabetes mellitus. Furthermore, the umbrella review also assesses the evidence on potential mediating mechanisms.

METHODS AND ANALYSIS: The present umbrella review will consist of a comprehensive systematic search of published systematic reviews and meta-analyses of observational longitudinal studies investigating whether a psychiatric disorder is associated with the risk of developing type 2 diabetes. PubMed, Embase, PsychINFO and the Cochrane Database of Systematic Reviews will be searched, and the results will be screened for inclusion by two independent reviewers. Furthermore, the reference lists of included publications will be manually searched. Two independent reviewers will extract data and assess the methodological quality in the included systematic reviews and meta-analyses. Evidence on potential mediating mechanisms included in the systematic reviews and meta-analyses will also be reviewed. The implications of the overview will be discussed in light of the quality of the included studies, and suggestions for clinical practice and future research will be made.

ETHICS AND DISSEMINATION: Ethical approval is not required for this umbrella review. Our review will be submitted for publication in a peer-reviewed international journal using open access option if available. The results will also be disseminated at international conferences.

PROSPERO REGISTRATION NUMBER: CRD42018096362.

Original languageEnglish
Article numbere024981
JournalBMJ Open
Volume9
Issue number5
Number of pages5
ISSN2044-6055
DOIs
Publication statusPublished - 30. May 2019

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Type 2 Diabetes Mellitus
Meta-Analysis
Longitudinal Studies
Publications
PubMed
Databases

Keywords

  • diabetes mellitus
  • mental disorders
  • risk factors
  • umbrella review

Cite this

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title = "Psychiatric disorders as risk factors for the development of type 2 diabetes mellitus: an umbrella review protocol",
abstract = "INTRODUCTION: Numerous longitudinal studies, systematic reviews and meta-analyses have examined psychiatric disorders as risk factors for the development of type 2 diabetes mellitus. A more comprehensive overview of the area is warranted to summarise current evidence and discuss strengths and weaknesses to guide future research.AIM: The aim of this umbrella review is to determine whether and to what extent different psychiatric disorders are associated with the development of type 2 diabetes mellitus. Furthermore, the umbrella review also assesses the evidence on potential mediating mechanisms.METHODS AND ANALYSIS: The present umbrella review will consist of a comprehensive systematic search of published systematic reviews and meta-analyses of observational longitudinal studies investigating whether a psychiatric disorder is associated with the risk of developing type 2 diabetes. PubMed, Embase, PsychINFO and the Cochrane Database of Systematic Reviews will be searched, and the results will be screened for inclusion by two independent reviewers. Furthermore, the reference lists of included publications will be manually searched. Two independent reviewers will extract data and assess the methodological quality in the included systematic reviews and meta-analyses. Evidence on potential mediating mechanisms included in the systematic reviews and meta-analyses will also be reviewed. The implications of the overview will be discussed in light of the quality of the included studies, and suggestions for clinical practice and future research will be made.ETHICS AND DISSEMINATION: Ethical approval is not required for this umbrella review. Our review will be submitted for publication in a peer-reviewed international journal using open access option if available. The results will also be disseminated at international conferences.PROSPERO REGISTRATION NUMBER: CRD42018096362.",
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Psychiatric disorders as risk factors for the development of type 2 diabetes mellitus : an umbrella review protocol. / Lindekilde, Nanna; Nefs, Giesje; Henriksen, Jan Erik; Lasgaard, Mathias; Schram, Miranda; Rubin, Katrine; Rutters, Femke; Kivimaki, Mika; Pouwer, Frans.

In: BMJ Open, Vol. 9, No. 5, e024981, 30.05.2019.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Psychiatric disorders as risk factors for the development of type 2 diabetes mellitus

T2 - an umbrella review protocol

AU - Lindekilde, Nanna

AU - Nefs, Giesje

AU - Henriksen, Jan Erik

AU - Lasgaard, Mathias

AU - Schram, Miranda

AU - Rubin, Katrine

AU - Rutters, Femke

AU - Kivimaki, Mika

AU - Pouwer, Frans

PY - 2019/5/30

Y1 - 2019/5/30

N2 - INTRODUCTION: Numerous longitudinal studies, systematic reviews and meta-analyses have examined psychiatric disorders as risk factors for the development of type 2 diabetes mellitus. A more comprehensive overview of the area is warranted to summarise current evidence and discuss strengths and weaknesses to guide future research.AIM: The aim of this umbrella review is to determine whether and to what extent different psychiatric disorders are associated with the development of type 2 diabetes mellitus. Furthermore, the umbrella review also assesses the evidence on potential mediating mechanisms.METHODS AND ANALYSIS: The present umbrella review will consist of a comprehensive systematic search of published systematic reviews and meta-analyses of observational longitudinal studies investigating whether a psychiatric disorder is associated with the risk of developing type 2 diabetes. PubMed, Embase, PsychINFO and the Cochrane Database of Systematic Reviews will be searched, and the results will be screened for inclusion by two independent reviewers. Furthermore, the reference lists of included publications will be manually searched. Two independent reviewers will extract data and assess the methodological quality in the included systematic reviews and meta-analyses. Evidence on potential mediating mechanisms included in the systematic reviews and meta-analyses will also be reviewed. The implications of the overview will be discussed in light of the quality of the included studies, and suggestions for clinical practice and future research will be made.ETHICS AND DISSEMINATION: Ethical approval is not required for this umbrella review. Our review will be submitted for publication in a peer-reviewed international journal using open access option if available. The results will also be disseminated at international conferences.PROSPERO REGISTRATION NUMBER: CRD42018096362.

AB - INTRODUCTION: Numerous longitudinal studies, systematic reviews and meta-analyses have examined psychiatric disorders as risk factors for the development of type 2 diabetes mellitus. A more comprehensive overview of the area is warranted to summarise current evidence and discuss strengths and weaknesses to guide future research.AIM: The aim of this umbrella review is to determine whether and to what extent different psychiatric disorders are associated with the development of type 2 diabetes mellitus. Furthermore, the umbrella review also assesses the evidence on potential mediating mechanisms.METHODS AND ANALYSIS: The present umbrella review will consist of a comprehensive systematic search of published systematic reviews and meta-analyses of observational longitudinal studies investigating whether a psychiatric disorder is associated with the risk of developing type 2 diabetes. PubMed, Embase, PsychINFO and the Cochrane Database of Systematic Reviews will be searched, and the results will be screened for inclusion by two independent reviewers. Furthermore, the reference lists of included publications will be manually searched. Two independent reviewers will extract data and assess the methodological quality in the included systematic reviews and meta-analyses. Evidence on potential mediating mechanisms included in the systematic reviews and meta-analyses will also be reviewed. The implications of the overview will be discussed in light of the quality of the included studies, and suggestions for clinical practice and future research will be made.ETHICS AND DISSEMINATION: Ethical approval is not required for this umbrella review. Our review will be submitted for publication in a peer-reviewed international journal using open access option if available. The results will also be disseminated at international conferences.PROSPERO REGISTRATION NUMBER: CRD42018096362.

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KW - mental disorders

KW - risk factors

KW - umbrella review

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DO - 10.1136/bmjopen-2018-024981

M3 - Journal article

C2 - 31152031

VL - 9

JO - B M J Open

JF - B M J Open

SN - 2044-6055

IS - 5

M1 - e024981

ER -