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Psoralen-fatty acid cycloadducts activate protein kinase C (PKC) in human platelets

  • S Caffieri
  • , M Ruzzene
  • , B Guerra
  • , S Frank
  • , D Vedaldi
  • , F Dall'Acqua
  • Unknown

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The C4-photocycloadduct psoralen-linolenic acid activates protein kinase C (PKC), in human platelets, which in turn phosphorylates 47 kDa protein, representing its major substrate in these cells. This behaviour is similar to that shown by diacylglycerol, a main second messenger responsible of various biological effects, e.g. of melanogenesis.
Original languageEnglish
JournalJournal of Photochemistry and Photobiology B: Biology
Volume22
Issue number3
Pages (from-to)253-6
Number of pages3
ISSN1011-1344
Publication statusPublished - 1. Mar 1994
Externally publishedYes

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