Protective roles for myeloid cells in neuroinflammation

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Myeloid cells represent the major cellular component of innate immune responses. Myeloid cells include monocytes and macrophages, granulocytes (neutrophils, basophils and eosinophils) and dendritic cells (DC). The role of myeloid cells has been broadly described both in physiological and in pathological conditions. All tissues or organs are equipped with resident myeloid cells, such as parenchymal microglia in the brain, which contribute to maintaining homeostasis. Moreover, in case of infection or tissue damage, other myeloid cells such as monocytes or granulocytes (especially neutrophils) can be recruited from the circulation, at first to promote inflammation and later to participate in repair and regeneration. This review aims to address the regulatory roles of myeloid cells in inflammatory diseases of the central nervous system (CNS), with a particular focus on recent work showing induction of suppressive function via stimulation of innate signalling in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE).

Original languageEnglish
Article numbere12963
JournalScandinavian Journal of Immunology
Volume92
Issue number5
Number of pages7
ISSN0300-9475
DOIs
Publication statusPublished - Nov 2020

Keywords

  • autoimmunity
  • cytokines
  • inflammation
  • innate receptors
  • macrophages
  • microglia
  • monocytes
  • multiple sclerosis
  • neutrophils
  • suppression

Fingerprint Dive into the research topics of 'Protective roles for myeloid cells in neuroinflammation'. Together they form a unique fingerprint.

Cite this