Protective roles for myeloid cells in neuroinflammation

Trevor Owens*, Anouk Benmamar-Badel, Agnieszka Wlodarczyk, Joanna Marczynska, Marlene T. Mørch, Magdalena Dubik, Dina S. Arengoth, Nasrin Asgari, Gill Webster, Reza Khorooshi

*Corresponding author for this work

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Myeloid cells represent the major cellular component of innate immune responses. Myeloid cells include monocytes and macrophages, granulocytes (neutrophils, basophils and eosinophils) and dendritic cells (DC). The role of myeloid cells has been broadly described both in physiological and in pathological conditions. All tissues or organs are equipped with resident myeloid cells, such as parenchymal microglia in the brain, which contribute to maintaining homeostasis. Moreover, in case of infection or tissue damage, other myeloid cells such as monocytes or granulocytes (especially neutrophils) can be recruited from the circulation, at first to promote inflammation and later to participate in repair and regeneration. This review aims to address the regulatory roles of myeloid cells in inflammatory diseases of the central nervous system (CNS), with a particular focus on recent work showing induction of suppressive function via stimulation of innate signalling in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE).

Original languageEnglish
Article numbere12963
JournalScandinavian Journal of Immunology
Issue number5
Number of pages7
Publication statusPublished - Nov 2020


  • autoimmunity
  • cytokines
  • inflammation
  • innate receptors
  • macrophages
  • microglia
  • monocytes
  • multiple sclerosis
  • neutrophils
  • suppression


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