Prognostic value of suPAR and hs-CRP on cardiovascular disease

Marie Zöga Diederichsen*, Søren Zöga Diederichsen, Hans Mickley, Flemming Hald Steffensen, Jess Lambrechtsen, Niels Peter Rønnow Sand, Kent Lodberg Christensen, Michael Hecht Olsen, Axel Diederichsen, Mette Hjortdal Grønhøj

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Background and aims: Studies have shown that soluble urokinase Plasminogen Activator Receptor (suPAR) and CRP (both inflammatory markers) and coronary artery calcification (CAC) are independent risk predictors for cardiovascular (CV) disease. The aim of this study is to assess whether suPAR and CRP have an increased predictive prognostic value beyond the traditional CV risk factors and the CAC score. Methods: A population sample of 1179 subjects, free of CV disease was included. The subjects underwent traditional CV risk evaluation, CAC assessment and blood sampling for suPAR and CRP. CV events were extracted from The Danish National Patient Register after 6.5 years. The additive values of suPAR and CRP were evaluated by unadjusted Kaplan Meier analysis, adjusted hazard ratio and ROCAUC models. Results: 1179 participants (47.6% males, mean age 55 years) were included. 73 events occurred. In Kaplan Meier analyses, suPAR and CRP were significantly associated with CV events (p = 0.03 and p = 0.002). Adjusted for the CV risk factors and the CAC score, the hazard ratios for suPAR and CRP were 1.17 (95% confidence interval [CI] 1.01–1.34) and 1.04 (95% CI 1.01–1.06), respectively. suPAR was associated with a substantial risk among women (2.03; 95% CI 1.45–2.84) and 60-year-old subjects (1.44; 95% CI 1.09–1.90). By ROCAUC, neither suPAR nor CRP provided significant estimates (0.7100 and 0.7054) compared to the traditionally CV risk factors (0.6952, p = 0.24 and p = 0.16) and CAC score (0.7481, p = 0.33 and p = 0.32). Conclusions: Adjusted for traditional CV risk factors and CAC score, suPAR and CRP were of minor importance in risk prediction.

Original languageEnglish
JournalAtherosclerosis
Volume271
Pages (from-to)245-251
ISSN0021-9150
DOIs
Publication statusPublished - 2018

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Urokinase Plasminogen Activator Receptors
Confidence Intervals

Keywords

  • Atherosclerosis
  • Cardiovascular disease
  • Cardiovascular risk factors
  • Coronary artery calcification
  • High-sensitive C-reactive-protein
  • Inflammatory markers
  • Soluble urokinase plasminogen activator receptor

Cite this

Diederichsen, Marie Zöga ; Diederichsen, Søren Zöga ; Mickley, Hans ; Steffensen, Flemming Hald ; Lambrechtsen, Jess ; Sand, Niels Peter Rønnow ; Christensen, Kent Lodberg ; Olsen, Michael Hecht ; Diederichsen, Axel ; Grønhøj, Mette Hjortdal. / Prognostic value of suPAR and hs-CRP on cardiovascular disease. In: Atherosclerosis. 2018 ; Vol. 271. pp. 245-251.
@article{ca24d875a56d42caa93d2dce876b3cd2,
title = "Prognostic value of suPAR and hs-CRP on cardiovascular disease",
abstract = "Background and aims: Studies have shown that soluble urokinase Plasminogen Activator Receptor (suPAR) and CRP (both inflammatory markers) and coronary artery calcification (CAC) are independent risk predictors for cardiovascular (CV) disease. The aim of this study is to assess whether suPAR and CRP have an increased predictive prognostic value beyond the traditional CV risk factors and the CAC score. Methods: A population sample of 1179 subjects, free of CV disease was included. The subjects underwent traditional CV risk evaluation, CAC assessment and blood sampling for suPAR and CRP. CV events were extracted from The Danish National Patient Register after 6.5 years. The additive values of suPAR and CRP were evaluated by unadjusted Kaplan Meier analysis, adjusted hazard ratio and ROCAUC models. Results: 1179 participants (47.6{\%} males, mean age 55 years) were included. 73 events occurred. In Kaplan Meier analyses, suPAR and CRP were significantly associated with CV events (p = 0.03 and p = 0.002). Adjusted for the CV risk factors and the CAC score, the hazard ratios for suPAR and CRP were 1.17 (95{\%} confidence interval [CI] 1.01–1.34) and 1.04 (95{\%} CI 1.01–1.06), respectively. suPAR was associated with a substantial risk among women (2.03; 95{\%} CI 1.45–2.84) and 60-year-old subjects (1.44; 95{\%} CI 1.09–1.90). By ROCAUC, neither suPAR nor CRP provided significant estimates (0.7100 and 0.7054) compared to the traditionally CV risk factors (0.6952, p = 0.24 and p = 0.16) and CAC score (0.7481, p = 0.33 and p = 0.32). Conclusions: Adjusted for traditional CV risk factors and CAC score, suPAR and CRP were of minor importance in risk prediction.",
keywords = "Atherosclerosis, Cardiovascular disease, Cardiovascular risk factors, Coronary artery calcification, High-sensitive C-reactive-protein, Inflammatory markers, Soluble urokinase plasminogen activator receptor",
author = "Diederichsen, {Marie Z{\"o}ga} and Diederichsen, {S{\o}ren Z{\"o}ga} and Hans Mickley and Steffensen, {Flemming Hald} and Jess Lambrechtsen and Sand, {Niels Peter R{\o}nnow} and Christensen, {Kent Lodberg} and Olsen, {Michael Hecht} and Axel Diederichsen and Gr{\o}nh{\o}j, {Mette Hjortdal}",
year = "2018",
doi = "10.1016/j.atherosclerosis.2018.01.029",
language = "English",
volume = "271",
pages = "245--251",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier",

}

Prognostic value of suPAR and hs-CRP on cardiovascular disease. / Diederichsen, Marie Zöga; Diederichsen, Søren Zöga; Mickley, Hans; Steffensen, Flemming Hald; Lambrechtsen, Jess; Sand, Niels Peter Rønnow; Christensen, Kent Lodberg; Olsen, Michael Hecht; Diederichsen, Axel; Grønhøj, Mette Hjortdal.

In: Atherosclerosis, Vol. 271, 2018, p. 245-251.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Prognostic value of suPAR and hs-CRP on cardiovascular disease

AU - Diederichsen, Marie Zöga

AU - Diederichsen, Søren Zöga

AU - Mickley, Hans

AU - Steffensen, Flemming Hald

AU - Lambrechtsen, Jess

AU - Sand, Niels Peter Rønnow

AU - Christensen, Kent Lodberg

AU - Olsen, Michael Hecht

AU - Diederichsen, Axel

AU - Grønhøj, Mette Hjortdal

PY - 2018

Y1 - 2018

N2 - Background and aims: Studies have shown that soluble urokinase Plasminogen Activator Receptor (suPAR) and CRP (both inflammatory markers) and coronary artery calcification (CAC) are independent risk predictors for cardiovascular (CV) disease. The aim of this study is to assess whether suPAR and CRP have an increased predictive prognostic value beyond the traditional CV risk factors and the CAC score. Methods: A population sample of 1179 subjects, free of CV disease was included. The subjects underwent traditional CV risk evaluation, CAC assessment and blood sampling for suPAR and CRP. CV events were extracted from The Danish National Patient Register after 6.5 years. The additive values of suPAR and CRP were evaluated by unadjusted Kaplan Meier analysis, adjusted hazard ratio and ROCAUC models. Results: 1179 participants (47.6% males, mean age 55 years) were included. 73 events occurred. In Kaplan Meier analyses, suPAR and CRP were significantly associated with CV events (p = 0.03 and p = 0.002). Adjusted for the CV risk factors and the CAC score, the hazard ratios for suPAR and CRP were 1.17 (95% confidence interval [CI] 1.01–1.34) and 1.04 (95% CI 1.01–1.06), respectively. suPAR was associated with a substantial risk among women (2.03; 95% CI 1.45–2.84) and 60-year-old subjects (1.44; 95% CI 1.09–1.90). By ROCAUC, neither suPAR nor CRP provided significant estimates (0.7100 and 0.7054) compared to the traditionally CV risk factors (0.6952, p = 0.24 and p = 0.16) and CAC score (0.7481, p = 0.33 and p = 0.32). Conclusions: Adjusted for traditional CV risk factors and CAC score, suPAR and CRP were of minor importance in risk prediction.

AB - Background and aims: Studies have shown that soluble urokinase Plasminogen Activator Receptor (suPAR) and CRP (both inflammatory markers) and coronary artery calcification (CAC) are independent risk predictors for cardiovascular (CV) disease. The aim of this study is to assess whether suPAR and CRP have an increased predictive prognostic value beyond the traditional CV risk factors and the CAC score. Methods: A population sample of 1179 subjects, free of CV disease was included. The subjects underwent traditional CV risk evaluation, CAC assessment and blood sampling for suPAR and CRP. CV events were extracted from The Danish National Patient Register after 6.5 years. The additive values of suPAR and CRP were evaluated by unadjusted Kaplan Meier analysis, adjusted hazard ratio and ROCAUC models. Results: 1179 participants (47.6% males, mean age 55 years) were included. 73 events occurred. In Kaplan Meier analyses, suPAR and CRP were significantly associated with CV events (p = 0.03 and p = 0.002). Adjusted for the CV risk factors and the CAC score, the hazard ratios for suPAR and CRP were 1.17 (95% confidence interval [CI] 1.01–1.34) and 1.04 (95% CI 1.01–1.06), respectively. suPAR was associated with a substantial risk among women (2.03; 95% CI 1.45–2.84) and 60-year-old subjects (1.44; 95% CI 1.09–1.90). By ROCAUC, neither suPAR nor CRP provided significant estimates (0.7100 and 0.7054) compared to the traditionally CV risk factors (0.6952, p = 0.24 and p = 0.16) and CAC score (0.7481, p = 0.33 and p = 0.32). Conclusions: Adjusted for traditional CV risk factors and CAC score, suPAR and CRP were of minor importance in risk prediction.

KW - Atherosclerosis

KW - Cardiovascular disease

KW - Cardiovascular risk factors

KW - Coronary artery calcification

KW - High-sensitive C-reactive-protein

KW - Inflammatory markers

KW - Soluble urokinase plasminogen activator receptor

U2 - 10.1016/j.atherosclerosis.2018.01.029

DO - 10.1016/j.atherosclerosis.2018.01.029

M3 - Journal article

C2 - 29402404

AN - SCOPUS:85041288031

VL - 271

SP - 245

EP - 251

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

ER -