Prognostic factors associated with mortality in patients with septic arthritis: a descriptive cohort study

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Objectives: To evaluate the 30-day mortality rate of septic arthritis (SA) in adults in Funen, central Denmark, and to explore whether, at the time of SA presentation, risk factors for the 30-day mortality rate could be revealed. Our secondary objective was to describe the microbiological aetiologies, systemic signs of inflammation, and co-morbidity. Method: A descriptive study identifying patients with SA from central Denmark, during the period 2006–2013, by the use of joint fluid culture data retrieved from the electronic database at the Department of Clinical Microbiology, Odense University Hospital. Patients with a positive joint fluid culture were considered eligible and their medical records were examined. Results: We identified 215 patients with SA, mean age 64.8 years. At presentation, mean C-reactive protein (CRP) was 204 mg/L, mean white blood cell count (WBC) 11.9 × 10 9/L, and mean body temperature 37.6°C. A total of 101 patients (47%) had a prosthetic joint, 46 (21%) had an inflammatory joint disease, and 24 (11%) had diabetes mellitus (DM). Staphylococcus aureus was the most common pathogen (104 patients, 48.4%). The 30-day mortality rate was 9.3% and the significant risk factor for death was liver disease at time of presentation [odds ratio (OR) 40.40, 95% confidence interval (CI) 5.38–303]. The other factors tested such as age > 65 years, elevated temperature, rheumatoid arthritis (RA), prostheses, and diabetes mellitus (DM) did not reach statistical significance. Conclusions: In our sample of patients with SA, we found a 30-day mortality rate in almost one in 10 adults. Among possible explanations, our study indicates that liver disease is a clinically relevant risk factor.

Original languageEnglish
JournalScandinavian Journal of Rheumatology
Volume46
Issue number1
Pages (from-to)27-32
ISSN0300-9742
DOIs
Publication statusPublished - Jan 2017

Fingerprint

Cohort Studies
Joints
Denmark
Liver Diseases
Diabetes Mellitus
Joint Diseases
Microbiology
Prostheses and Implants
Medical Records
Odds Ratio
Databases
Confidence Intervals

Keywords

  • Aged
  • Anti-Bacterial Agents/therapeutic use
  • Arthritis, Infectious/drug therapy
  • Cohort Studies
  • Denmark/epidemiology
  • Female
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Prognosis
  • Risk Factors

Cite this

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title = "Prognostic factors associated with mortality in patients with septic arthritis: a descriptive cohort study",
abstract = "Objectives: To evaluate the 30-day mortality rate of septic arthritis (SA) in adults in Funen, central Denmark, and to explore whether, at the time of SA presentation, risk factors for the 30-day mortality rate could be revealed. Our secondary objective was to describe the microbiological aetiologies, systemic signs of inflammation, and co-morbidity. Method: A descriptive study identifying patients with SA from central Denmark, during the period 2006–2013, by the use of joint fluid culture data retrieved from the electronic database at the Department of Clinical Microbiology, Odense University Hospital. Patients with a positive joint fluid culture were considered eligible and their medical records were examined. Results: We identified 215 patients with SA, mean age 64.8 years. At presentation, mean C-reactive protein (CRP) was 204 mg/L, mean white blood cell count (WBC) 11.9 × 10 9/L, and mean body temperature 37.6°C. A total of 101 patients (47{\%}) had a prosthetic joint, 46 (21{\%}) had an inflammatory joint disease, and 24 (11{\%}) had diabetes mellitus (DM). Staphylococcus aureus was the most common pathogen (104 patients, 48.4{\%}). The 30-day mortality rate was 9.3{\%} and the significant risk factor for death was liver disease at time of presentation [odds ratio (OR) 40.40, 95{\%} confidence interval (CI) 5.38–303]. The other factors tested such as age > 65 years, elevated temperature, rheumatoid arthritis (RA), prostheses, and diabetes mellitus (DM) did not reach statistical significance. Conclusions: In our sample of patients with SA, we found a 30-day mortality rate in almost one in 10 adults. Among possible explanations, our study indicates that liver disease is a clinically relevant risk factor.",
keywords = "Aged, Anti-Bacterial Agents/therapeutic use, Arthritis, Infectious/drug therapy, Cohort Studies, Denmark/epidemiology, Female, Humans, Incidence, Male, Middle Aged, Prognosis, Risk Factors",
author = "{Asmussen Andreasen}, Rikke and Andersen, {Nanna Skaarup} and Just, {S{\o}ren Andreas} and Robin Christensen and {Jensen Hansen}, {Inger Marie}",
year = "2017",
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doi = "10.3109/03009742.2016.1164241",
language = "English",
volume = "46",
pages = "27--32",
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}

Prognostic factors associated with mortality in patients with septic arthritis : a descriptive cohort study. / Asmussen Andreasen, Rikke; Andersen, Nanna Skaarup ; Just, Søren Andreas; Christensen, Robin ; Jensen Hansen, Inger Marie.

In: Scandinavian Journal of Rheumatology, Vol. 46, No. 1, 01.2017, p. 27-32.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Prognostic factors associated with mortality in patients with septic arthritis

T2 - a descriptive cohort study

AU - Asmussen Andreasen, Rikke

AU - Andersen, Nanna Skaarup

AU - Just, Søren Andreas

AU - Christensen, Robin

AU - Jensen Hansen, Inger Marie

PY - 2017/1

Y1 - 2017/1

N2 - Objectives: To evaluate the 30-day mortality rate of septic arthritis (SA) in adults in Funen, central Denmark, and to explore whether, at the time of SA presentation, risk factors for the 30-day mortality rate could be revealed. Our secondary objective was to describe the microbiological aetiologies, systemic signs of inflammation, and co-morbidity. Method: A descriptive study identifying patients with SA from central Denmark, during the period 2006–2013, by the use of joint fluid culture data retrieved from the electronic database at the Department of Clinical Microbiology, Odense University Hospital. Patients with a positive joint fluid culture were considered eligible and their medical records were examined. Results: We identified 215 patients with SA, mean age 64.8 years. At presentation, mean C-reactive protein (CRP) was 204 mg/L, mean white blood cell count (WBC) 11.9 × 10 9/L, and mean body temperature 37.6°C. A total of 101 patients (47%) had a prosthetic joint, 46 (21%) had an inflammatory joint disease, and 24 (11%) had diabetes mellitus (DM). Staphylococcus aureus was the most common pathogen (104 patients, 48.4%). The 30-day mortality rate was 9.3% and the significant risk factor for death was liver disease at time of presentation [odds ratio (OR) 40.40, 95% confidence interval (CI) 5.38–303]. The other factors tested such as age > 65 years, elevated temperature, rheumatoid arthritis (RA), prostheses, and diabetes mellitus (DM) did not reach statistical significance. Conclusions: In our sample of patients with SA, we found a 30-day mortality rate in almost one in 10 adults. Among possible explanations, our study indicates that liver disease is a clinically relevant risk factor.

AB - Objectives: To evaluate the 30-day mortality rate of septic arthritis (SA) in adults in Funen, central Denmark, and to explore whether, at the time of SA presentation, risk factors for the 30-day mortality rate could be revealed. Our secondary objective was to describe the microbiological aetiologies, systemic signs of inflammation, and co-morbidity. Method: A descriptive study identifying patients with SA from central Denmark, during the period 2006–2013, by the use of joint fluid culture data retrieved from the electronic database at the Department of Clinical Microbiology, Odense University Hospital. Patients with a positive joint fluid culture were considered eligible and their medical records were examined. Results: We identified 215 patients with SA, mean age 64.8 years. At presentation, mean C-reactive protein (CRP) was 204 mg/L, mean white blood cell count (WBC) 11.9 × 10 9/L, and mean body temperature 37.6°C. A total of 101 patients (47%) had a prosthetic joint, 46 (21%) had an inflammatory joint disease, and 24 (11%) had diabetes mellitus (DM). Staphylococcus aureus was the most common pathogen (104 patients, 48.4%). The 30-day mortality rate was 9.3% and the significant risk factor for death was liver disease at time of presentation [odds ratio (OR) 40.40, 95% confidence interval (CI) 5.38–303]. The other factors tested such as age > 65 years, elevated temperature, rheumatoid arthritis (RA), prostheses, and diabetes mellitus (DM) did not reach statistical significance. Conclusions: In our sample of patients with SA, we found a 30-day mortality rate in almost one in 10 adults. Among possible explanations, our study indicates that liver disease is a clinically relevant risk factor.

KW - Aged

KW - Anti-Bacterial Agents/therapeutic use

KW - Arthritis, Infectious/drug therapy

KW - Cohort Studies

KW - Denmark/epidemiology

KW - Female

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Prognosis

KW - Risk Factors

U2 - 10.3109/03009742.2016.1164241

DO - 10.3109/03009742.2016.1164241

M3 - Journal article

C2 - 27309379

VL - 46

SP - 27

EP - 32

JO - Scandinavian Journal of Rheumatology

JF - Scandinavian Journal of Rheumatology

SN - 0300-9742

IS - 1

ER -