Process synthesis for natural products from plants based on PAT methodology

Chandrakant Ramkrishna Malwade, Haiyan Qu, Ben-Guang Rong, Lars Porskjær Christensen

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Abstract

Natural products are defined as secondary metabolites produced by plants and form a vast pool of compounds with unlimited chemical and functional diversity. Many of these secondary metabolites are high value added chemicals that are frequently used as ingredients in food, cosmetics, pharmaceuticals and other consumer products. Therefore, process technology towards industrial scale production of such high value chemicals from plants has significant importance. In this chapter, a process synthesis methodology for recovery of natural products from plants at conceptual level is discussed. The methodology generates different process flowsheet alternatives consisting of multiple separation techniques. Decision making is supported by heuristics as well as basic process information already available from previous studies. In addition, process analytical technology (PAT) framework, a part of Quality by Design (QbD) approach, has been included at various steps to obtain molecular level information of process streams and thereby, support the rational decision making. The formulated methodology has been used to isolate and purify artemisinin, an antimalarial drug, from dried leaves of the plant Artemisia annua. A process flowsheet is generated consisting of maceration, flash column chromatography and crystallization unit operations for extraction, partial purification and final purification of artemisinin, respectively. PAT tools such as high performance liquid chromatography (HPLC), liquid chromatography-mass spectroscopy (LC-MS) and chemometric methods have been used extensively to characterize the process streams at molecular level and the generated process information is used to further optimize the process flowsheet.
Original languageEnglish
Title of host publicationProcess Synthesis and Process Intensification : Methodological Approaches
EditorsBen-Guang Rong
PublisherDe Gruyter
Publication date2017
Pages291-325
Chapter8
ISBN (Print)9783110465051, 3110465051
ISBN (Electronic)9783110465068
DOIs
Publication statusPublished - 2017
SeriesDe Gruyter Textbook

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Flowcharting
Biological Products
Metabolites
Purification
Decision making
Column chromatography
Consumer products
Cosmetics
Liquid chromatography
Antimalarials
High performance liquid chromatography
Crystallization
Spectroscopy
Recovery
Pharmaceutical Preparations
artemisinine

Cite this

Malwade, C. R., Qu, H., Rong, B-G., & Christensen, L. P. (2017). Process synthesis for natural products from plants based on PAT methodology. In B-G. Rong (Ed.), Process Synthesis and Process Intensification: Methodological Approaches (pp. 291-325). De Gruyter. De Gruyter Textbook https://doi.org/10.1515/9783110465068-008
Malwade, Chandrakant Ramkrishna ; Qu, Haiyan ; Rong, Ben-Guang ; Christensen, Lars Porskjær . / Process synthesis for natural products from plants based on PAT methodology. Process Synthesis and Process Intensification: Methodological Approaches. editor / Ben-Guang Rong. De Gruyter, 2017. pp. 291-325 (De Gruyter Textbook).
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Malwade, CR, Qu, H, Rong, B-G & Christensen, LP 2017, Process synthesis for natural products from plants based on PAT methodology. in B-G Rong (ed.), Process Synthesis and Process Intensification: Methodological Approaches. De Gruyter, De Gruyter Textbook, pp. 291-325. https://doi.org/10.1515/9783110465068-008

Process synthesis for natural products from plants based on PAT methodology. / Malwade, Chandrakant Ramkrishna; Qu, Haiyan; Rong, Ben-Guang; Christensen, Lars Porskjær .

Process Synthesis and Process Intensification: Methodological Approaches. ed. / Ben-Guang Rong. De Gruyter, 2017. p. 291-325 (De Gruyter Textbook).

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

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Malwade CR, Qu H, Rong B-G, Christensen LP. Process synthesis for natural products from plants based on PAT methodology. In Rong B-G, editor, Process Synthesis and Process Intensification: Methodological Approaches. De Gruyter. 2017. p. 291-325. (De Gruyter Textbook). https://doi.org/10.1515/9783110465068-008