Principles for prevention of toxic effects from metals: General aspects

Philip J. Landrigan, David Kotelchuk, Philippe Grandjean

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch


Handbook of the Toxicology of Metals is the standard reference work for physicians, toxicologists and engineers in the field of environmental and occupational health. This new edition is a comprehensive review of the effects on biological systems from metallic elements and their compounds. An entirely new structure and illustrations represent the vast array of advancements made since the last edition. Special emphasis has been placed on the toxic effects in humans with chapters on the diagnosis, treatment and prevention of metal poisoning. This up-to-date reference provides easy access to a broad range of basic toxicological data and also gives a general introduction to the toxicology of metallic compounds
Toxicologists, physicians, and engineers in the fields of environmental and occupational health as well as libraries in these disciplines. Will also be a useful reference for governmental regulatory agencies and public health officers.
Introduction - General Considerations and International Perspectives General Chemistry, Sampling, Analytical Methods and Speciation Routes of Exposure, Dose, and Metabolism of Metals Biological Monitoring and Biomarkers Selected Molecular Mechanisms of Metal Toxicity and Carcinogenicity General Considerations of Dose-Effect and Dose-Response Relationships Interactions in Metal Toxicology Epidemiological Methods for Assessing Dose-Response and Dose-Effect Relationships Essential Metals: Assessing Risks from Deficiency and Toxicity Carcinogenicity of Metal Compounds Immunotoxicology of Metals Reproductive and Developmental Toxicity of Metals Ecotoxicology of Metals - Sources, Transport, and Effects in the Ecosystem Risk Assessment Diagnosis and Treatment of Metal Poisoning - General Aspects Principles for Prevention of the Toxic Effects of Metals Aluminum Antimony Arsenic Barium Beryllium Bismuth Cadmium Chromium Cobalt Copper Gallium and Semiconductor Compounds Germanium Indium Iron Lead Manganese Mercury Molybdenum Nickel Palladium Platinum Selenium Silver Tellurium Thallium Tin Titanium Tungsten Uranium Vanadium Zinc
Original languageEnglish
Title of host publicationHandbook on the toxicology of metals
EditorsGunnar F Nordberg, Bruce Fowler, Monica Nordberg, Lars T. Friberg
Number of pages17
Publication date2007
Edition3rd edition
ISBN (Print)978-0-12-369413-3
ISBN (Electronic)0-12-369413-2
Publication statusPublished - 2007



  • toxicology
  • Metals

Cite this

Landrigan, P. J., Kotelchuk, D., & Grandjean, P. (2007). Principles for prevention of toxic effects from metals: General aspects. In G. F. Nordberg, B. Fowler, M. Nordberg, & L. T. Friberg (Eds.), Handbook on the toxicology of metals (3rd edition ed., pp. 319-35). Elsevier.