Prevalence and risk of migraine in patients with rosacea: A population-based cohort study

Alexander Egeberg, Messoud Ashina, David Gaist, Gunnar H Gislason, Jacob P Thyssen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

BACKGROUND: Rosacea features increased neurovascular reactivity; migraine is a complex neurologic disorder characterized by recurrent episodes of headache associated with nausea and increased sensitivity to light and sound.

OBJECTIVE: We evaluated the prevalence and risk of new-onset migraine in patients with rosacea.

METHODS: All Danish individuals 18 years of age or older were linked in nationwide registers. Adjusted hazard ratios (HRs) were estimated by Cox regression.

RESULTS: In the total cohort (n = 4,361,688), there were 49,475 patients with rosacea. Baseline prevalence of migraine was 7.3% and 12.1% in the reference population and in patients with rosacea, respectively. The fully adjusted HR of migraine was 1.31 (95% confidence interval 1.23-1.39) for patients with rosacea. Patients with phymatous rosacea (n = 594) had no increased risk of migraine (adjusted HR 0.45; 95% confidence interval 0.11-1.80), whereas patients with ocular rosacea (n = 6977) had a 69% increased risk (adjusted HR 1.69; 95% confidence interval 1.43-1.99). Notably, the risk was higher among patients age 50 years or older than in younger individuals, and the risk was only significant among women.

LIMITATIONS: We were unable to distinguish between migraine subtypes.

CONCLUSION: We found a significantly higher prevalence and risk of incident migraine especially in female patients with rosacea. These data add to the accumulating evidence for a link between rosacea and the central nervous system.

Original languageEnglish
JournalAmerican Academy of Dermatology. Journal
Volume76
Issue number3
Pages (from-to)454-458
ISSN0190-9622
DOIs
Publication statusPublished - 2017

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Rosacea
Cohort Studies
Population
Confidence Intervals
Photophobia
Nervous System Diseases
Central Nervous System

Cite this

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title = "Prevalence and risk of migraine in patients with rosacea: A population-based cohort study",
abstract = "BACKGROUND: Rosacea features increased neurovascular reactivity; migraine is a complex neurologic disorder characterized by recurrent episodes of headache associated with nausea and increased sensitivity to light and sound.OBJECTIVE: We evaluated the prevalence and risk of new-onset migraine in patients with rosacea.METHODS: All Danish individuals 18 years of age or older were linked in nationwide registers. Adjusted hazard ratios (HRs) were estimated by Cox regression.RESULTS: In the total cohort (n = 4,361,688), there were 49,475 patients with rosacea. Baseline prevalence of migraine was 7.3{\%} and 12.1{\%} in the reference population and in patients with rosacea, respectively. The fully adjusted HR of migraine was 1.31 (95{\%} confidence interval 1.23-1.39) for patients with rosacea. Patients with phymatous rosacea (n = 594) had no increased risk of migraine (adjusted HR 0.45; 95{\%} confidence interval 0.11-1.80), whereas patients with ocular rosacea (n = 6977) had a 69{\%} increased risk (adjusted HR 1.69; 95{\%} confidence interval 1.43-1.99). Notably, the risk was higher among patients age 50 years or older than in younger individuals, and the risk was only significant among women.LIMITATIONS: We were unable to distinguish between migraine subtypes.CONCLUSION: We found a significantly higher prevalence and risk of incident migraine especially in female patients with rosacea. These data add to the accumulating evidence for a link between rosacea and the central nervous system.",
author = "Alexander Egeberg and Messoud Ashina and David Gaist and Gislason, {Gunnar H} and Thyssen, {Jacob P}",
note = "Copyright {\circledC} 2016 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.",
year = "2017",
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language = "English",
volume = "76",
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journal = "American Academy of Dermatology. Journal",
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Prevalence and risk of migraine in patients with rosacea : A population-based cohort study. / Egeberg, Alexander; Ashina, Messoud; Gaist, David; Gislason, Gunnar H; Thyssen, Jacob P.

In: American Academy of Dermatology. Journal, Vol. 76, No. 3, 2017, p. 454-458.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Prevalence and risk of migraine in patients with rosacea

T2 - A population-based cohort study

AU - Egeberg, Alexander

AU - Ashina, Messoud

AU - Gaist, David

AU - Gislason, Gunnar H

AU - Thyssen, Jacob P

N1 - Copyright © 2016 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

PY - 2017

Y1 - 2017

N2 - BACKGROUND: Rosacea features increased neurovascular reactivity; migraine is a complex neurologic disorder characterized by recurrent episodes of headache associated with nausea and increased sensitivity to light and sound.OBJECTIVE: We evaluated the prevalence and risk of new-onset migraine in patients with rosacea.METHODS: All Danish individuals 18 years of age or older were linked in nationwide registers. Adjusted hazard ratios (HRs) were estimated by Cox regression.RESULTS: In the total cohort (n = 4,361,688), there were 49,475 patients with rosacea. Baseline prevalence of migraine was 7.3% and 12.1% in the reference population and in patients with rosacea, respectively. The fully adjusted HR of migraine was 1.31 (95% confidence interval 1.23-1.39) for patients with rosacea. Patients with phymatous rosacea (n = 594) had no increased risk of migraine (adjusted HR 0.45; 95% confidence interval 0.11-1.80), whereas patients with ocular rosacea (n = 6977) had a 69% increased risk (adjusted HR 1.69; 95% confidence interval 1.43-1.99). Notably, the risk was higher among patients age 50 years or older than in younger individuals, and the risk was only significant among women.LIMITATIONS: We were unable to distinguish between migraine subtypes.CONCLUSION: We found a significantly higher prevalence and risk of incident migraine especially in female patients with rosacea. These data add to the accumulating evidence for a link between rosacea and the central nervous system.

AB - BACKGROUND: Rosacea features increased neurovascular reactivity; migraine is a complex neurologic disorder characterized by recurrent episodes of headache associated with nausea and increased sensitivity to light and sound.OBJECTIVE: We evaluated the prevalence and risk of new-onset migraine in patients with rosacea.METHODS: All Danish individuals 18 years of age or older were linked in nationwide registers. Adjusted hazard ratios (HRs) were estimated by Cox regression.RESULTS: In the total cohort (n = 4,361,688), there were 49,475 patients with rosacea. Baseline prevalence of migraine was 7.3% and 12.1% in the reference population and in patients with rosacea, respectively. The fully adjusted HR of migraine was 1.31 (95% confidence interval 1.23-1.39) for patients with rosacea. Patients with phymatous rosacea (n = 594) had no increased risk of migraine (adjusted HR 0.45; 95% confidence interval 0.11-1.80), whereas patients with ocular rosacea (n = 6977) had a 69% increased risk (adjusted HR 1.69; 95% confidence interval 1.43-1.99). Notably, the risk was higher among patients age 50 years or older than in younger individuals, and the risk was only significant among women.LIMITATIONS: We were unable to distinguish between migraine subtypes.CONCLUSION: We found a significantly higher prevalence and risk of incident migraine especially in female patients with rosacea. These data add to the accumulating evidence for a link between rosacea and the central nervous system.

U2 - 10.1016/j.jaad.2016.08.055

DO - 10.1016/j.jaad.2016.08.055

M3 - Journal article

C2 - 27817869

VL - 76

SP - 454

EP - 458

JO - American Academy of Dermatology. Journal

JF - American Academy of Dermatology. Journal

SN - 0190-9622

IS - 3

ER -