TY - JOUR
T1 - Prevalence and incidence of Parkinson's disease in The Faroe Islands
AU - Wermuth, L
AU - Bech, S
AU - Skaalum Petersen, M
AU - Joensen, P
AU - Weihe, P
AU - Grandjean, P
PY - 2008/8/1
Y1 - 2008/8/1
N2 - Objective - A study in The Faroe Islands in 1995 suggested a high prevalence of idiopathic Parkinson's disease (IPD) and total parkinsonism of 187.6 and 233.4 per 100,000 inhabitants respectively. Methods - Detailed case-finding methods 10 years later were used and a neurologist has verified the diagnosis. Results - The crude prevalence of IPD and total parkinsonism was 206.7 per 100,000 and 227.4 per 100,000 respectively. The age-adjusted prevalence is twice as high as data from Norway and Denmark. Age at initiation of treatment and the fatality rate did not explain the increased prevalence. During 1995-2005, the average annual incidence was 21.1 per 100,000 persons for Parkinson's disease, and 22.9 per 100,000 persons, if including atypical parkinsonism. Conclusion - The high prevalence was verified and linked to a high incidence. The cause of the high prevalence is unknown, but neurotoxic contaminants in traditional food may play a role in the pathogenesis in this population, perhaps jointly with genetic predisposition.
AB - Objective - A study in The Faroe Islands in 1995 suggested a high prevalence of idiopathic Parkinson's disease (IPD) and total parkinsonism of 187.6 and 233.4 per 100,000 inhabitants respectively. Methods - Detailed case-finding methods 10 years later were used and a neurologist has verified the diagnosis. Results - The crude prevalence of IPD and total parkinsonism was 206.7 per 100,000 and 227.4 per 100,000 respectively. The age-adjusted prevalence is twice as high as data from Norway and Denmark. Age at initiation of treatment and the fatality rate did not explain the increased prevalence. During 1995-2005, the average annual incidence was 21.1 per 100,000 persons for Parkinson's disease, and 22.9 per 100,000 persons, if including atypical parkinsonism. Conclusion - The high prevalence was verified and linked to a high incidence. The cause of the high prevalence is unknown, but neurotoxic contaminants in traditional food may play a role in the pathogenesis in this population, perhaps jointly with genetic predisposition.
U2 - 10.1111/j.1600-0404.2007.00991.x
DO - 10.1111/j.1600-0404.2007.00991.x
M3 - Journal article
C2 - 18294341
SN - 0001-6314
VL - 118
SP - 126
EP - 131
JO - Acta Neurologica Scandinavica
JF - Acta Neurologica Scandinavica
IS - 2
ER -