Pretransfusion Testing and the Selection of Red Cell Products for Transfusion

Mark H. Yazer, Meghan Delaney, Gregory A. Denomme

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The goal of pretransfusion compatibility testing is to ensure that serologically safe blood products are issued to the recipient. It is therefore crucial to accurately determine the recipient's blood type (ABO group, D type) and whether they have any unexpected red cell antibodies. The crossmatch ensures that an ABO‐compatible red cell has been selected for transfusion, and that the unit is antigen negative in the case of a recipient with an unexpected antibody. ABO‐ and D‐compatible platelets are preferable, but when these are not available, ABO‐ and D‐incompatible platelets may be used in adults. Under routine circumstances, plasma should be ABO compatible with the recipient, and AB plasma is the universal plasma donor group. The chapter shows the donor ABO groups that are compatible with the recipient's ABO group. For patients without antibodies, ABO compatibility is the only necessary compatibility consideration.
Original languageEnglish
Title of host publicationPractical Transfusion Medicine
EditorsMichael F. Murphy, David J. Roberts, Mark H. Yazer, Nancy M. Dunbar
Publication dateJun 2022
ISBN (Print)9781119665816
ISBN (Electronic)9781119665885
Publication statusPublished - Jun 2022


  • ABO-compatible red cell
  • D-compatible platelets
  • D-incompatible platelets
  • crossmatching techniques
  • pretransfusion compatibility testing
  • red cell antibodies
  • universal plasma donor group

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