Prenatal pesticide exposure associated with glycated haemoglobin and markers of metabolic dysfunction in adolescents

Helle Raun Andersen*, Jeanette Tinggaard, Philippe Grandjean, Tina K. Jensen, Christine Dalgård, Katharina M. Main

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Background: Pesticide exposure has been associated with increased risk of diabetes mellitus in adults, but potential effects of prenatal exposure on glucose regulation have not been investigated. The aim of this study was to investigate if maternal occupational pesticide exposure in pregnancy was associated with glycated haemoglobin A1c (HbA1c) in adolescents and whether an association was modified by sex and paraoxonase-1 (PON1) Q192R polymorphism. Methods: A prospective cohort study of children whose mothers were either occupationally exposed or unexposed to pesticides in early pregnancy. At age 10-to-16 years, the children (n = 168) underwent clinical examinations including pubertal stage assessment (accepted by 141 children) and blood sampling. PON1 Q192R genotype was available for 139 children and 103 mothers. The main outcome measure was HbA1c but other relevant biomarkers were also included. Results: Prenatal pesticide exposure was associated with a 5.0% (95% confidence interval: 1.8; 8.2) higher HbA1c compared to unexposed children after adjustment for confounders. After stratification, the association remained significant for girls (6.2% (1.6; 11.1)) and if the child or the mother had the PON1 192R-allele (6.1% (1.6; 10.8) and 7.1% (2.0; 12.6), respectively). Besides, an exposure-related increase was seen for the leptin-to-adiponectin ratio, for plasminogen activator inhibitor type-1 in girls, and for interleukin-6 in children whose mothers had the R-allele. Conclusion: Prenatal pesticide exposure was associated with higher HbA1c and changes in related biomarkers in adolescents. Our results suggest an adverse effect on glucose homeostasis and support previous findings from this cohort of an exposure-associated metabolic risk profile with higher susceptibility related to female sex and the PON1 192R-allele.

Original languageEnglish
JournalEnvironmental Research
Volume166
Pages (from-to)71-77
ISSN0013-9351
DOIs
Publication statusPublished - Oct 2018

Fingerprint

Glycosylated Hemoglobin A
hemoglobin
Aryldialkylphosphatase
Pesticides
pesticide
Mothers
Hemoglobins
Biomarkers
allele
Alleles
Association reactions
pregnancy
Glucose
biomarker
glucose
Adiponectin
Plasminogen Activator Inhibitor 1
Medical problems
Leptin
Polymorphism

Keywords

  • HbA1c
  • Metabolic biomarkers
  • Paraoxonase-1
  • Pesticides
  • Prenatal exposure

Cite this

@article{d80527c674db4e06915469f2893d85b2,
title = "Prenatal pesticide exposure associated with glycated haemoglobin and markers of metabolic dysfunction in adolescents",
abstract = "Background: Pesticide exposure has been associated with increased risk of diabetes mellitus in adults, but potential effects of prenatal exposure on glucose regulation have not been investigated. The aim of this study was to investigate if maternal occupational pesticide exposure in pregnancy was associated with glycated haemoglobin A1c (HbA1c) in adolescents and whether an association was modified by sex and paraoxonase-1 (PON1) Q192R polymorphism. Methods: A prospective cohort study of children whose mothers were either occupationally exposed or unexposed to pesticides in early pregnancy. At age 10-to-16 years, the children (n = 168) underwent clinical examinations including pubertal stage assessment (accepted by 141 children) and blood sampling. PON1 Q192R genotype was available for 139 children and 103 mothers. The main outcome measure was HbA1c but other relevant biomarkers were also included. Results: Prenatal pesticide exposure was associated with a 5.0{\%} (95{\%} confidence interval: 1.8; 8.2) higher HbA1c compared to unexposed children after adjustment for confounders. After stratification, the association remained significant for girls (6.2{\%} (1.6; 11.1)) and if the child or the mother had the PON1 192R-allele (6.1{\%} (1.6; 10.8) and 7.1{\%} (2.0; 12.6), respectively). Besides, an exposure-related increase was seen for the leptin-to-adiponectin ratio, for plasminogen activator inhibitor type-1 in girls, and for interleukin-6 in children whose mothers had the R-allele. Conclusion: Prenatal pesticide exposure was associated with higher HbA1c and changes in related biomarkers in adolescents. Our results suggest an adverse effect on glucose homeostasis and support previous findings from this cohort of an exposure-associated metabolic risk profile with higher susceptibility related to female sex and the PON1 192R-allele.",
keywords = "HbA1c, Metabolic biomarkers, Paraoxonase-1, Pesticides, Prenatal exposure",
author = "Andersen, {Helle Raun} and Jeanette Tinggaard and Philippe Grandjean and Jensen, {Tina K.} and Christine Dalg{\aa}rd and Main, {Katharina M.}",
year = "2018",
month = "10",
doi = "10.1016/j.envres.2018.05.032",
language = "English",
volume = "166",
pages = "71--77",
journal = "Environmental Research",
issn = "0013-9351",
publisher = "Heinemann",

}

Prenatal pesticide exposure associated with glycated haemoglobin and markers of metabolic dysfunction in adolescents. / Andersen, Helle Raun; Tinggaard, Jeanette; Grandjean, Philippe; Jensen, Tina K.; Dalgård, Christine; Main, Katharina M.

In: Environmental Research, Vol. 166, 10.2018, p. 71-77.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Prenatal pesticide exposure associated with glycated haemoglobin and markers of metabolic dysfunction in adolescents

AU - Andersen, Helle Raun

AU - Tinggaard, Jeanette

AU - Grandjean, Philippe

AU - Jensen, Tina K.

AU - Dalgård, Christine

AU - Main, Katharina M.

PY - 2018/10

Y1 - 2018/10

N2 - Background: Pesticide exposure has been associated with increased risk of diabetes mellitus in adults, but potential effects of prenatal exposure on glucose regulation have not been investigated. The aim of this study was to investigate if maternal occupational pesticide exposure in pregnancy was associated with glycated haemoglobin A1c (HbA1c) in adolescents and whether an association was modified by sex and paraoxonase-1 (PON1) Q192R polymorphism. Methods: A prospective cohort study of children whose mothers were either occupationally exposed or unexposed to pesticides in early pregnancy. At age 10-to-16 years, the children (n = 168) underwent clinical examinations including pubertal stage assessment (accepted by 141 children) and blood sampling. PON1 Q192R genotype was available for 139 children and 103 mothers. The main outcome measure was HbA1c but other relevant biomarkers were also included. Results: Prenatal pesticide exposure was associated with a 5.0% (95% confidence interval: 1.8; 8.2) higher HbA1c compared to unexposed children after adjustment for confounders. After stratification, the association remained significant for girls (6.2% (1.6; 11.1)) and if the child or the mother had the PON1 192R-allele (6.1% (1.6; 10.8) and 7.1% (2.0; 12.6), respectively). Besides, an exposure-related increase was seen for the leptin-to-adiponectin ratio, for plasminogen activator inhibitor type-1 in girls, and for interleukin-6 in children whose mothers had the R-allele. Conclusion: Prenatal pesticide exposure was associated with higher HbA1c and changes in related biomarkers in adolescents. Our results suggest an adverse effect on glucose homeostasis and support previous findings from this cohort of an exposure-associated metabolic risk profile with higher susceptibility related to female sex and the PON1 192R-allele.

AB - Background: Pesticide exposure has been associated with increased risk of diabetes mellitus in adults, but potential effects of prenatal exposure on glucose regulation have not been investigated. The aim of this study was to investigate if maternal occupational pesticide exposure in pregnancy was associated with glycated haemoglobin A1c (HbA1c) in adolescents and whether an association was modified by sex and paraoxonase-1 (PON1) Q192R polymorphism. Methods: A prospective cohort study of children whose mothers were either occupationally exposed or unexposed to pesticides in early pregnancy. At age 10-to-16 years, the children (n = 168) underwent clinical examinations including pubertal stage assessment (accepted by 141 children) and blood sampling. PON1 Q192R genotype was available for 139 children and 103 mothers. The main outcome measure was HbA1c but other relevant biomarkers were also included. Results: Prenatal pesticide exposure was associated with a 5.0% (95% confidence interval: 1.8; 8.2) higher HbA1c compared to unexposed children after adjustment for confounders. After stratification, the association remained significant for girls (6.2% (1.6; 11.1)) and if the child or the mother had the PON1 192R-allele (6.1% (1.6; 10.8) and 7.1% (2.0; 12.6), respectively). Besides, an exposure-related increase was seen for the leptin-to-adiponectin ratio, for plasminogen activator inhibitor type-1 in girls, and for interleukin-6 in children whose mothers had the R-allele. Conclusion: Prenatal pesticide exposure was associated with higher HbA1c and changes in related biomarkers in adolescents. Our results suggest an adverse effect on glucose homeostasis and support previous findings from this cohort of an exposure-associated metabolic risk profile with higher susceptibility related to female sex and the PON1 192R-allele.

KW - HbA1c

KW - Metabolic biomarkers

KW - Paraoxonase-1

KW - Pesticides

KW - Prenatal exposure

U2 - 10.1016/j.envres.2018.05.032

DO - 10.1016/j.envres.2018.05.032

M3 - Journal article

C2 - 29879566

AN - SCOPUS:85047863349

VL - 166

SP - 71

EP - 77

JO - Environmental Research

JF - Environmental Research

SN - 0013-9351

ER -