Predictors of new vertebral endplate signal (Modic) changes in the general population

Tue Secher Jensen, Per Kjaer, Lars Korsholm, Tom Bendix, Joan S Sorensen, Claus Manniche, Charlotte Leboeuf-Yde

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Vertebral endplate signal changes (VESC), also known as Modic changes, have been reported to be associated with low back pain (LBP). However, little is known about predisposing factors for the development of new VESC. The aim of this study was to investigate the predictive value of lifestyle factors and disc-related magnetic resonance imaging (MRI) findings in relation to the development of new VESC. This prospective observational study included 344 people from the Danish general population who had an MRI and completed LBP questionnaires at the age of 40 and again at 44 years. Potential predictors of new VESC were female gender, disc-related MRI findings (disc degeneration, disc bulges, disc herniation, and other endplate changes) and lifestyle factors [high physical work or leisure activity, high body mass index (BMI), and heavy smoking]. Bivariate and multivariate logistic regressions were used to identify predictors of new VESC. New VESC at the age of 44 appeared in 67 of the 344. The majority (84%) of these new signal changes were type 1 VESC and almost half (45%) were only in the endplate and did not extend into the vertebral body. In the multivariate analysis, lumbar disc levels with disc degeneration, bulges or herniations at 40 were the only predictors of new VESC at age 44. Therefore, the development of new VESC at the age of 44 appears to be based on the status and dynamics of the disc, rather than being the result of gender or lifestyle factors such as smoking and physical load.
Original languageEnglish
JournalEuropean Spine Journal
Volume19
Issue number1
Pages (from-to)129-35
Number of pages7
ISSN0940-6719
DOIs
Publication statusPublished - 1. Jan 2010

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Intervertebral Disc Degeneration
Low Back Pain
Smoking
Population
Leisure Activities
Causality
Body Mass Index
Multivariate Analysis
Logistic Models
Prospective Studies
Surveys and Questionnaires

Keywords

  • Adult
  • Age Factors
  • Aging
  • Cohort Studies
  • Comorbidity
  • Denmark
  • Disease Progression
  • Female
  • Humans
  • Intervertebral Disk
  • Intervertebral Disk Degeneration
  • Low Back Pain
  • Lumbar Vertebrae
  • Magnetic Resonance Imaging
  • Male
  • Obesity
  • Predictive Value of Tests
  • Prognosis
  • Prospective Studies
  • Questionnaires
  • Risk Factors
  • Risk Reduction Behavior
  • Sedentary Lifestyle
  • Smoking

Cite this

Jensen, Tue Secher ; Kjaer, Per ; Korsholm, Lars ; Bendix, Tom ; Sorensen, Joan S ; Manniche, Claus ; Leboeuf-Yde, Charlotte. / Predictors of new vertebral endplate signal (Modic) changes in the general population. In: European Spine Journal. 2010 ; Vol. 19, No. 1. pp. 129-35.
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abstract = "Vertebral endplate signal changes (VESC), also known as Modic changes, have been reported to be associated with low back pain (LBP). However, little is known about predisposing factors for the development of new VESC. The aim of this study was to investigate the predictive value of lifestyle factors and disc-related magnetic resonance imaging (MRI) findings in relation to the development of new VESC. This prospective observational study included 344 people from the Danish general population who had an MRI and completed LBP questionnaires at the age of 40 and again at 44 years. Potential predictors of new VESC were female gender, disc-related MRI findings (disc degeneration, disc bulges, disc herniation, and other endplate changes) and lifestyle factors [high physical work or leisure activity, high body mass index (BMI), and heavy smoking]. Bivariate and multivariate logistic regressions were used to identify predictors of new VESC. New VESC at the age of 44 appeared in 67 of the 344. The majority (84{\%}) of these new signal changes were type 1 VESC and almost half (45{\%}) were only in the endplate and did not extend into the vertebral body. In the multivariate analysis, lumbar disc levels with disc degeneration, bulges or herniations at 40 were the only predictors of new VESC at age 44. Therefore, the development of new VESC at the age of 44 appears to be based on the status and dynamics of the disc, rather than being the result of gender or lifestyle factors such as smoking and physical load.",
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Predictors of new vertebral endplate signal (Modic) changes in the general population. / Jensen, Tue Secher; Kjaer, Per; Korsholm, Lars; Bendix, Tom; Sorensen, Joan S; Manniche, Claus; Leboeuf-Yde, Charlotte.

In: European Spine Journal, Vol. 19, No. 1, 01.01.2010, p. 129-35.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Predictors of new vertebral endplate signal (Modic) changes in the general population

AU - Jensen, Tue Secher

AU - Kjaer, Per

AU - Korsholm, Lars

AU - Bendix, Tom

AU - Sorensen, Joan S

AU - Manniche, Claus

AU - Leboeuf-Yde, Charlotte

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PY - 2010/1/1

Y1 - 2010/1/1

N2 - Vertebral endplate signal changes (VESC), also known as Modic changes, have been reported to be associated with low back pain (LBP). However, little is known about predisposing factors for the development of new VESC. The aim of this study was to investigate the predictive value of lifestyle factors and disc-related magnetic resonance imaging (MRI) findings in relation to the development of new VESC. This prospective observational study included 344 people from the Danish general population who had an MRI and completed LBP questionnaires at the age of 40 and again at 44 years. Potential predictors of new VESC were female gender, disc-related MRI findings (disc degeneration, disc bulges, disc herniation, and other endplate changes) and lifestyle factors [high physical work or leisure activity, high body mass index (BMI), and heavy smoking]. Bivariate and multivariate logistic regressions were used to identify predictors of new VESC. New VESC at the age of 44 appeared in 67 of the 344. The majority (84%) of these new signal changes were type 1 VESC and almost half (45%) were only in the endplate and did not extend into the vertebral body. In the multivariate analysis, lumbar disc levels with disc degeneration, bulges or herniations at 40 were the only predictors of new VESC at age 44. Therefore, the development of new VESC at the age of 44 appears to be based on the status and dynamics of the disc, rather than being the result of gender or lifestyle factors such as smoking and physical load.

AB - Vertebral endplate signal changes (VESC), also known as Modic changes, have been reported to be associated with low back pain (LBP). However, little is known about predisposing factors for the development of new VESC. The aim of this study was to investigate the predictive value of lifestyle factors and disc-related magnetic resonance imaging (MRI) findings in relation to the development of new VESC. This prospective observational study included 344 people from the Danish general population who had an MRI and completed LBP questionnaires at the age of 40 and again at 44 years. Potential predictors of new VESC were female gender, disc-related MRI findings (disc degeneration, disc bulges, disc herniation, and other endplate changes) and lifestyle factors [high physical work or leisure activity, high body mass index (BMI), and heavy smoking]. Bivariate and multivariate logistic regressions were used to identify predictors of new VESC. New VESC at the age of 44 appeared in 67 of the 344. The majority (84%) of these new signal changes were type 1 VESC and almost half (45%) were only in the endplate and did not extend into the vertebral body. In the multivariate analysis, lumbar disc levels with disc degeneration, bulges or herniations at 40 were the only predictors of new VESC at age 44. Therefore, the development of new VESC at the age of 44 appears to be based on the status and dynamics of the disc, rather than being the result of gender or lifestyle factors such as smoking and physical load.

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KW - Comorbidity

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KW - Humans

KW - Intervertebral Disk

KW - Intervertebral Disk Degeneration

KW - Low Back Pain

KW - Lumbar Vertebrae

KW - Magnetic Resonance Imaging

KW - Male

KW - Obesity

KW - Predictive Value of Tests

KW - Prognosis

KW - Prospective Studies

KW - Questionnaires

KW - Risk Factors

KW - Risk Reduction Behavior

KW - Sedentary Lifestyle

KW - Smoking

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DO - 10.1007/s00586-009-1184-5

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JO - European Spine Journal

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SN - 0940-6719

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