Predictive value of retinal oximetry, optical coherence tomography angiography and microperimetry in patients with treatment-naïve branch retinal vein occlusion

Katrine Hartmund Frederiksen; Frederik Nørregaard Pedersen; Anna Stage Vergmann; Dawei Yang; Caroline Schmidt Laugesen; Jesper Pindbo Vestergaard; Torben Lykke Sørensen; Carol Y. Cheung; Ryo Kawasaki; Tunde Peto; Jakob Grauslund

doi:10.1186/s40942-023-00468-7

Predictive value of retinal oximetry, optical coherence tomography angiography and microperimetry in patients with treatment-naïve branch retinal vein occlusion

Katrine Hartmund Frederiksen^*
, Frederik Nørregaard Pedersen
, Anna Stage Vergmann
, Dawei Yang
, Caroline Schmidt Laugesen
, Jesper Pindbo Vestergaard
, Torben Lykke Sørensen
, Carol Y. Cheung
, Ryo Kawasaki
, Tunde Peto
, Jakob Grauslund

^*Corresponding author for this work

Department of Obstetrics and Gynaecology, Prince of Wales Hospital, the Chinese University of Hong Kong, Hong Kong Special Administrative Region.
Zealand University Hospital, Roskilde
University of Copenhagen
Osaka University
Queen's University Belfast

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

Vascular endothelial growth factor inhibitors have substantially improved the visual outcomes in patients with macular edema (ME) caused by branch retinal vein occlusion (BRVO), but treatment outcomes are highly variable and early prediction of expected clinical outcome would be important for individualized treatment. As non-invasive metabolic, structural and functional retinal markers might act as early predictors of clinical outcomes, we performed a 12-month, prospective study aimed to evaluate if baseline retinal oximetry, optical coherence tomography angiography (OCT-A) or microperimetry were able to predict need of treatment, structural or functional outcome in patients with ME caused by treatment-näive BRVO. We evaluated 41 eyes of 41 patients with a mean age of 69.6 years and 56% females. We found a strong tendency towards a higher retinal arteriolar oxygen saturation in patients without a need of additional aflibercept treatment after the loading phase (99.8% vs. 92.3%, adjusted odds ratio 0.80 (95% confidence interval 0.64-1.00), adjusted p = 0.058), but otherwise, retinal oximetry, OCT-A or microperimetry were not able to predict need of treatment, structural nor functional outcomes. (Trial registration: clinicaltrials.gov, S-20,170,084. Registered 24 August 2014, https://clinicaltrials.gov/ct2/show/NCT03651011)

Original language	English
Article number	38
Journal	International Journal of Retina and Vitreous
Volume	9
Issue number	1
Number of pages	5
ISSN	2056-9920
DOIs	https://doi.org/10.1186/s40942-023-00468-7
Publication status	Published - Dec 2023

Funding

JG conceptualized and initiated the study. JG and KHF acquired financial support. KHF, FNP, ASV, CSL, JPV, TLS and JG conducted patient inclusion and follow-up visits. DY and CYC analyzed and interpreted OCT-A MATLAB analyses. KHF had full access to all data in the study, and take responsibility for the data integrity and accuracy of the data analysis. KHF drafted the manuscript. All authors contributed to the design of the study; interpretation of data and critical revision and editing of the manuscript. The corresponding author attests that all listed authors met authorship criteria, and that no others meeting the criteria have been omitted from the author list.

Keywords

Branch retinal vein occlusion
Microperimetry
Optical coherence tomography angiography
Retinal oximetry
Vascular endothelial growth factor inhibition

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1 Ph.D. thesis

Cardiovascular disease, mortality and treatment in retinal vein occlusion: a nationwide registry-based, and a clinical study
Frederiksen, K. H., 4. Nov 2022, Syddansk Universitet. Det Sundhedsvidenskabelige Fakultet. 164 p.
Research output: Thesis › Ph.D. thesis

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Frederiksen, K. H., Pedersen, F. N., Vergmann, A. S., Yang, D., Laugesen, C. S., Vestergaard, J. P., Sørensen, T. L., Cheung, C. Y., Kawasaki, R., Peto, T., & Grauslund, J. (2023). Predictive value of retinal oximetry, optical coherence tomography angiography and microperimetry in patients with treatment-naïve branch retinal vein occlusion. International Journal of Retina and Vitreous, 9(1), Article 38. https://doi.org/10.1186/s40942-023-00468-7

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title = "Predictive value of retinal oximetry, optical coherence tomography angiography and microperimetry in patients with treatment-na{\"i}ve branch retinal vein occlusion",

abstract = "Vascular endothelial growth factor inhibitors have substantially improved the visual outcomes in patients with macular edema (ME) caused by branch retinal vein occlusion (BRVO), but treatment outcomes are highly variable and early prediction of expected clinical outcome would be important for individualized treatment. As non-invasive metabolic, structural and functional retinal markers might act as early predictors of clinical outcomes, we performed a 12-month, prospective study aimed to evaluate if baseline retinal oximetry, optical coherence tomography angiography (OCT-A) or microperimetry were able to predict need of treatment, structural or functional outcome in patients with ME caused by treatment-n{\"a}ive BRVO. We evaluated 41 eyes of 41 patients with a mean age of 69.6 years and 56\% females. We found a strong tendency towards a higher retinal arteriolar oxygen saturation in patients without a need of additional aflibercept treatment after the loading phase (99.8\% vs. 92.3\%, adjusted odds ratio 0.80 (95\% confidence interval 0.64-1.00), adjusted p = 0.058), but otherwise, retinal oximetry, OCT-A or microperimetry were not able to predict need of treatment, structural nor functional outcomes. (Trial registration: clinicaltrials.gov, S-20,170,084. Registered 24 August 2014, https://clinicaltrials.gov/ct2/show/NCT03651011)",

keywords = "Branch retinal vein occlusion, Microperimetry, Optical coherence tomography angiography, Retinal oximetry, Vascular endothelial growth factor inhibition",

author = "Frederiksen, \{Katrine Hartmund\} and Pedersen, \{Frederik N{\o}rregaard\} and Vergmann, \{Anna Stage\} and Dawei Yang and Laugesen, \{Caroline Schmidt\} and Vestergaard, \{Jesper Pindbo\} and S{\o}rensen, \{Torben Lykke\} and Cheung, \{Carol Y.\} and Ryo Kawasaki and Tunde Peto and Jakob Grauslund",

note = "Funding Information: JG conceptualized and initiated the study. JG and KHF acquired financial support. KHF, FNP, ASV, CSL, JPV, TLS and JG conducted patient inclusion and follow-up visits. DY and CYC analyzed and interpreted OCT-A MATLAB analyses. KHF had full access to all data in the study, and take responsibility for the data integrity and accuracy of the data analysis. KHF drafted the manuscript. All authors contributed to the design of the study; interpretation of data and critical revision and editing of the manuscript. The corresponding author attests that all listed authors met authorship criteria, and that no others meeting the criteria have been omitted from the author list. ",

year = "2023",

month = dec,

doi = "10.1186/s40942-023-00468-7",

language = "English",

volume = "9",

journal = "International Journal of Retina and Vitreous",

issn = "2056-9920",

publisher = "BioMed Central",

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Frederiksen, KH, Pedersen, FN , Vergmann, AS, Yang, D, Laugesen, CS, Vestergaard, JP, Sørensen, TL, Cheung, CY, Kawasaki, R , Peto, T & Grauslund, J 2023, 'Predictive value of retinal oximetry, optical coherence tomography angiography and microperimetry in patients with treatment-naïve branch retinal vein occlusion', International Journal of Retina and Vitreous, vol. 9, no. 1, 38. https://doi.org/10.1186/s40942-023-00468-7

Predictive value of retinal oximetry, optical coherence tomography angiography and microperimetry in patients with treatment-naïve branch retinal vein occlusion. / Frederiksen, Katrine Hartmund; Pedersen, Frederik Nørregaard ; Vergmann, Anna Stage et al.
In: International Journal of Retina and Vitreous, Vol. 9, No. 1, 38, 12.2023.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - Predictive value of retinal oximetry, optical coherence tomography angiography and microperimetry in patients with treatment-naïve branch retinal vein occlusion

AU - Frederiksen, Katrine Hartmund

AU - Pedersen, Frederik Nørregaard

AU - Vergmann, Anna Stage

AU - Yang, Dawei

AU - Laugesen, Caroline Schmidt

AU - Vestergaard, Jesper Pindbo

AU - Sørensen, Torben Lykke

AU - Cheung, Carol Y.

AU - Kawasaki, Ryo

AU - Peto, Tunde

AU - Grauslund, Jakob

N1 - Funding Information: JG conceptualized and initiated the study. JG and KHF acquired financial support. KHF, FNP, ASV, CSL, JPV, TLS and JG conducted patient inclusion and follow-up visits. DY and CYC analyzed and interpreted OCT-A MATLAB analyses. KHF had full access to all data in the study, and take responsibility for the data integrity and accuracy of the data analysis. KHF drafted the manuscript. All authors contributed to the design of the study; interpretation of data and critical revision and editing of the manuscript. The corresponding author attests that all listed authors met authorship criteria, and that no others meeting the criteria have been omitted from the author list.

PY - 2023/12

Y1 - 2023/12

N2 - Vascular endothelial growth factor inhibitors have substantially improved the visual outcomes in patients with macular edema (ME) caused by branch retinal vein occlusion (BRVO), but treatment outcomes are highly variable and early prediction of expected clinical outcome would be important for individualized treatment. As non-invasive metabolic, structural and functional retinal markers might act as early predictors of clinical outcomes, we performed a 12-month, prospective study aimed to evaluate if baseline retinal oximetry, optical coherence tomography angiography (OCT-A) or microperimetry were able to predict need of treatment, structural or functional outcome in patients with ME caused by treatment-näive BRVO. We evaluated 41 eyes of 41 patients with a mean age of 69.6 years and 56% females. We found a strong tendency towards a higher retinal arteriolar oxygen saturation in patients without a need of additional aflibercept treatment after the loading phase (99.8% vs. 92.3%, adjusted odds ratio 0.80 (95% confidence interval 0.64-1.00), adjusted p = 0.058), but otherwise, retinal oximetry, OCT-A or microperimetry were not able to predict need of treatment, structural nor functional outcomes. (Trial registration: clinicaltrials.gov, S-20,170,084. Registered 24 August 2014, https://clinicaltrials.gov/ct2/show/NCT03651011)

AB - Vascular endothelial growth factor inhibitors have substantially improved the visual outcomes in patients with macular edema (ME) caused by branch retinal vein occlusion (BRVO), but treatment outcomes are highly variable and early prediction of expected clinical outcome would be important for individualized treatment. As non-invasive metabolic, structural and functional retinal markers might act as early predictors of clinical outcomes, we performed a 12-month, prospective study aimed to evaluate if baseline retinal oximetry, optical coherence tomography angiography (OCT-A) or microperimetry were able to predict need of treatment, structural or functional outcome in patients with ME caused by treatment-näive BRVO. We evaluated 41 eyes of 41 patients with a mean age of 69.6 years and 56% females. We found a strong tendency towards a higher retinal arteriolar oxygen saturation in patients without a need of additional aflibercept treatment after the loading phase (99.8% vs. 92.3%, adjusted odds ratio 0.80 (95% confidence interval 0.64-1.00), adjusted p = 0.058), but otherwise, retinal oximetry, OCT-A or microperimetry were not able to predict need of treatment, structural nor functional outcomes. (Trial registration: clinicaltrials.gov, S-20,170,084. Registered 24 August 2014, https://clinicaltrials.gov/ct2/show/NCT03651011)

KW - Branch retinal vein occlusion

KW - Microperimetry

KW - Optical coherence tomography angiography

KW - Retinal oximetry

KW - Vascular endothelial growth factor inhibition

U2 - 10.1186/s40942-023-00468-7

DO - 10.1186/s40942-023-00468-7

M3 - Journal article

C2 - 37381014

AN - SCOPUS:85163701738

SN - 2056-9920

VL - 9

JO - International Journal of Retina and Vitreous

JF - International Journal of Retina and Vitreous

IS - 1

M1 - 38

ER -

Predictive value of retinal oximetry, optical coherence tomography angiography and microperimetry in patients with treatment-naïve branch retinal vein occlusion

Abstract

Funding

Keywords

Documents & Links

SDU Link

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Related research output

Cardiovascular disease, mortality and treatment in retinal vein occlusion: a nationwide registry-based, and a clinical study

Cite this