Prediction of 28-days mortality with sequential organ failure assessment (SOFA), quick SOFA (qSOFA) and systemic inflammatory response syndrome (SIRS) — A retrospective study of medical patients with acute infectious disease

Shahin Gaini*, Mette Marie Relster, Court Pedersen, Isik Somuncu Johansen

*Corresponding author for this work

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Abstract

Aims: Evaluating the use of sequential organ failure assessment (SOFA) ≥ 2 compared to quick SOFA (qSOFA) and to systemic inflammatory response syndrome (SIRS) in assessing 28-days mortality in medical patients with acute infection. Methods: In total, 323 patients with verified infection were stratified in accordance to Sepsis-3. SOFA, qSOFA and SIRS were calculated using registered variables. Adverse outcome was death within 28-days of admission. Results: In total, 190 (59%) patients had a SOFA score ≥ 2 and the overall in-hospital mortality was 21 (6%). Scores of SOFA and qSOFA were both significantly elevated in non-survivors. SOFA showed good accuracy (Area under the receiver operating characteristic (AUROC) = 0.83, 95% CI, 0.76 - 0.90) for 28-days mortality compared with qSOFA (AUROC = 0.67, 95% CI, 0.54 - 0.80) and SIRS (AUROC = 0.62, 95% Cl 0.49 - 0.74). SOFA was ≥ 2 in all patients who died, while qSOFA and SIRS was ≥ 2 in 8 (38%) and 17 (81%) of the patients who died, respectively. Conclusion: SOFA score ≥ 2 was better than SIRS and qSOFA to predict mortality within 28-days of admission among patients with acute infectious disease.

Original languageEnglish
JournalInternational Journal of Infectious Diseases
Volume78
Pages (from-to)1-7
ISSN1201-9712
DOIs
Publication statusPublished - Jan 2019

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Acute Disease
Retrospective Studies
ROC Curve
Patient Admission
Hospital Mortality

Bibliographical note

Copyright © 2018 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Keywords

  • Acute Disease
  • Adult
  • Aged
  • Communicable Diseases/diagnosis
  • Female
  • Follow-Up Studies
  • Hospital Mortality
  • Hospitalization
  • Humans
  • Male
  • Middle Aged
  • Organ Dysfunction Scores
  • Prognosis
  • Retrospective Studies
  • Sepsis/diagnosis
  • Systemic Inflammatory Response Syndrome/diagnosis

Cite this

@article{98569285b71a498da8f2163d7210fd70,
title = "Prediction of 28-days mortality with sequential organ failure assessment (SOFA), quick SOFA (qSOFA) and systemic inflammatory response syndrome (SIRS) — A retrospective study of medical patients with acute infectious disease",
abstract = "Aims: Evaluating the use of sequential organ failure assessment (SOFA) ≥ 2 compared to quick SOFA (qSOFA) and to systemic inflammatory response syndrome (SIRS) in assessing 28-days mortality in medical patients with acute infection. Methods: In total, 323 patients with verified infection were stratified in accordance to Sepsis-3. SOFA, qSOFA and SIRS were calculated using registered variables. Adverse outcome was death within 28-days of admission. Results: In total, 190 (59{\%}) patients had a SOFA score ≥ 2 and the overall in-hospital mortality was 21 (6{\%}). Scores of SOFA and qSOFA were both significantly elevated in non-survivors. SOFA showed good accuracy (Area under the receiver operating characteristic (AUROC) = 0.83, 95{\%} CI, 0.76 - 0.90) for 28-days mortality compared with qSOFA (AUROC = 0.67, 95{\%} CI, 0.54 - 0.80) and SIRS (AUROC = 0.62, 95{\%} Cl 0.49 - 0.74). SOFA was ≥ 2 in all patients who died, while qSOFA and SIRS was ≥ 2 in 8 (38{\%}) and 17 (81{\%}) of the patients who died, respectively. Conclusion: SOFA score ≥ 2 was better than SIRS and qSOFA to predict mortality within 28-days of admission among patients with acute infectious disease.",
keywords = "Acute Disease, Adult, Aged, Communicable Diseases/diagnosis, Female, Follow-Up Studies, Hospital Mortality, Hospitalization, Humans, Male, Middle Aged, Organ Dysfunction Scores, Prognosis, Retrospective Studies, Sepsis/diagnosis, Systemic Inflammatory Response Syndrome/diagnosis",
author = "Shahin Gaini and Relster, {Mette Marie} and Court Pedersen and Johansen, {Isik Somuncu}",
note = "Copyright {\circledC} 2018 The Author(s). Published by Elsevier Ltd.. All rights reserved.",
year = "2019",
month = "1",
doi = "10.1016/j.ijid.2018.09.020",
language = "English",
volume = "78",
pages = "1--7",
journal = "International Journal of Infectious Diseases",
issn = "1201-9712",
publisher = "Elsevier",

}

TY - JOUR

T1 - Prediction of 28-days mortality with sequential organ failure assessment (SOFA), quick SOFA (qSOFA) and systemic inflammatory response syndrome (SIRS) — A retrospective study of medical patients with acute infectious disease

AU - Gaini, Shahin

AU - Relster, Mette Marie

AU - Pedersen, Court

AU - Johansen, Isik Somuncu

N1 - Copyright © 2018 The Author(s). Published by Elsevier Ltd.. All rights reserved.

PY - 2019/1

Y1 - 2019/1

N2 - Aims: Evaluating the use of sequential organ failure assessment (SOFA) ≥ 2 compared to quick SOFA (qSOFA) and to systemic inflammatory response syndrome (SIRS) in assessing 28-days mortality in medical patients with acute infection. Methods: In total, 323 patients with verified infection were stratified in accordance to Sepsis-3. SOFA, qSOFA and SIRS were calculated using registered variables. Adverse outcome was death within 28-days of admission. Results: In total, 190 (59%) patients had a SOFA score ≥ 2 and the overall in-hospital mortality was 21 (6%). Scores of SOFA and qSOFA were both significantly elevated in non-survivors. SOFA showed good accuracy (Area under the receiver operating characteristic (AUROC) = 0.83, 95% CI, 0.76 - 0.90) for 28-days mortality compared with qSOFA (AUROC = 0.67, 95% CI, 0.54 - 0.80) and SIRS (AUROC = 0.62, 95% Cl 0.49 - 0.74). SOFA was ≥ 2 in all patients who died, while qSOFA and SIRS was ≥ 2 in 8 (38%) and 17 (81%) of the patients who died, respectively. Conclusion: SOFA score ≥ 2 was better than SIRS and qSOFA to predict mortality within 28-days of admission among patients with acute infectious disease.

AB - Aims: Evaluating the use of sequential organ failure assessment (SOFA) ≥ 2 compared to quick SOFA (qSOFA) and to systemic inflammatory response syndrome (SIRS) in assessing 28-days mortality in medical patients with acute infection. Methods: In total, 323 patients with verified infection were stratified in accordance to Sepsis-3. SOFA, qSOFA and SIRS were calculated using registered variables. Adverse outcome was death within 28-days of admission. Results: In total, 190 (59%) patients had a SOFA score ≥ 2 and the overall in-hospital mortality was 21 (6%). Scores of SOFA and qSOFA were both significantly elevated in non-survivors. SOFA showed good accuracy (Area under the receiver operating characteristic (AUROC) = 0.83, 95% CI, 0.76 - 0.90) for 28-days mortality compared with qSOFA (AUROC = 0.67, 95% CI, 0.54 - 0.80) and SIRS (AUROC = 0.62, 95% Cl 0.49 - 0.74). SOFA was ≥ 2 in all patients who died, while qSOFA and SIRS was ≥ 2 in 8 (38%) and 17 (81%) of the patients who died, respectively. Conclusion: SOFA score ≥ 2 was better than SIRS and qSOFA to predict mortality within 28-days of admission among patients with acute infectious disease.

KW - Acute Disease

KW - Adult

KW - Aged

KW - Communicable Diseases/diagnosis

KW - Female

KW - Follow-Up Studies

KW - Hospital Mortality

KW - Hospitalization

KW - Humans

KW - Male

KW - Middle Aged

KW - Organ Dysfunction Scores

KW - Prognosis

KW - Retrospective Studies

KW - Sepsis/diagnosis

KW - Systemic Inflammatory Response Syndrome/diagnosis

U2 - 10.1016/j.ijid.2018.09.020

DO - 10.1016/j.ijid.2018.09.020

M3 - Journal article

C2 - 30267939

AN - SCOPUS:85056267485

VL - 78

SP - 1

EP - 7

JO - International Journal of Infectious Diseases

JF - International Journal of Infectious Diseases

SN - 1201-9712

ER -