Precision medicine in allergic disease-food allergy, drug allergy, and anaphylaxis-PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma and Immunology

A Muraro, Robert F Lemanske, M Castells, M. J. Torres, D. Khan, Hans-Uwe Simon, C. Bindslev-Jensen, Wesley Burks, L K Poulsen, Hugh A Sampson, M Worm, Kari Christine Nadeau

Research output: Contribution to journalReviewResearchpeer-review

Abstract

This consensus document summarizes the current knowledge on the potential for precision medicine in food allergy, drug allergy, and anaphylaxis under the auspices of the PRACTALL collaboration platform. PRACTALL is a joint effort of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma and Immunology, which aims to synchronize the European and American approaches to allergy care. Precision medicine is an emerging approach for disease treatment based on disease endotypes, which are phenotypic subclasses associated with specific mechanisms underlying the disease. Although significant progress has been made in defining endotypes for asthma, definitions of endotypes for food and drug allergy or for anaphylaxis lag behind. Progress has been made in discovery of biomarkers to guide a precision medicine approach to treatment of food and drug allergy, but further validation and quantification of these biomarkers are needed to allow their translation into practice in the clinical management of allergic disease. Copyright

Original languageEnglish
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume72
Issue number2
Pages (from-to)1006–1021
ISSN0105-4538
DOIs
Publication statusPublished - 2017

Fingerprint

Drug Hypersensitivity
Precision Medicine
Food Hypersensitivity
Allergy and Immunology
Disease Management
Hypersensitivity

Keywords

  • Allergy
  • Anaphylaxis
  • Endotype
  • Phenotype
  • Precision medicine

Cite this

Muraro, A ; Lemanske, Robert F ; Castells, M ; Torres, M. J. ; Khan, D. ; Simon, Hans-Uwe ; Bindslev-Jensen, C. ; Burks, Wesley ; Poulsen, L K ; Sampson, Hugh A ; Worm, M ; Nadeau, Kari Christine. / Precision medicine in allergic disease-food allergy, drug allergy, and anaphylaxis-PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma and Immunology. In: Allergy: European Journal of Allergy and Clinical Immunology. 2017 ; Vol. 72, No. 2. pp. 1006–1021.
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Precision medicine in allergic disease-food allergy, drug allergy, and anaphylaxis-PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma and Immunology. / Muraro, A; Lemanske, Robert F; Castells, M; Torres, M. J.; Khan, D.; Simon, Hans-Uwe; Bindslev-Jensen, C.; Burks, Wesley; Poulsen, L K; Sampson, Hugh A; Worm, M; Nadeau, Kari Christine.

In: Allergy: European Journal of Allergy and Clinical Immunology, Vol. 72, No. 2, 2017, p. 1006–1021.

Research output: Contribution to journalReviewResearchpeer-review

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AU - Castells, M

AU - Torres, M. J.

AU - Khan, D.

AU - Simon, Hans-Uwe

AU - Bindslev-Jensen, C.

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AU - Sampson, Hugh A

AU - Worm, M

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