PPARgamma in adipocyte differentiation and metabolism: novel insights from genome-wide studies

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Abstract

Adipocyte differentiation is controlled by a tightly regulated transcriptional cascade in which PPARgamma and members of the C/EBP family are key players. Here we review the roles of PPARgamma and C/EBPs in adipocyte differentiation with emphasis on the recently published genome-wide binding profiles for PPARgamma and C/EBPalpha. Interestingly, these analyses show that PPARgamma and C/EBPalpha binding sites are associated with most genes that are induced during adipogenesis suggesting direct activation of many more adipocyte genes than previously anticipated. Furthermore, an extensive overlap between the C/EBPalpha and PPARgamma cistromes indicate a hitherto unrecognized direct crosstalk between these transcription factors. As more genome-wide data emerge in the future, this crosstalk will likely be found to include several other adipogenic transcription factors.
Original languageEnglish
JournalFEBS Letters
Volume584
Issue number15
Pages (from-to)3242-9
Number of pages8
DOIs
Publication statusPublished - 4. Aug 2010

Keywords

  • Adipocytes
  • Adipogenesis
  • Animals
  • CCAAT-Enhancer-Binding Proteins
  • Cell Differentiation
  • Genome-Wide Association Study
  • Humans
  • PPAR gamma

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