Positron emission tomography in chronic obstructive pulmonary disease

Poul Henning Madsen, Søren Hess, Poul Flemming Høilund-Carlsen, Abass Alavi

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The purpose of this paper was to systematically search the literature on 18F-fluorodeoxyglucose positron emission tomography ( 18F-FDG-PET) in the management of chronic obstructive pulmonary disease (COPD) and to provide a concise review of the reported results. Papers were searched through PubMed, EMBASE and Cochrane Library using the MESH terms "pulmonary disease, chronic obstructive", "pulmonary emphysema", and "positron-emission tomography". Of the 38 citations from the search and from browsing the literature lists of selected articles, seven relevant reports were identified. The sparse and heterogeneous literature available provide some indication that 18F-FDG-PET could prove useful in COPD by a) differentiating COPD from chronic asthma and alpha-1-antitrypsin deficiency, b) measuring pulmonary and systemic inflammation to guide treatment and estimate prognosis, c) quantifying respiratory muscle use, and d) diagnosing cor pulmonale. In conclusion, the role of 18F-FDG-PET in diagnosing and managing COPD patients seems to be promising and deserves to be further studied.

Original languageEnglish
JournalHellenic Journal of Nuclear Medicine
Volume16
Issue number2
Pages (from-to)121-124
ISSN1108-1430
Publication statusPublished - 2013

Keywords

  • COPD
  • Inflammation
  • PET
  • Pulmonary emphysema

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