Positron emission tomography imaging of drug-induced tumor apoptosis with a caspase-triggered nanoaggregation probe

Bin Shen; Jongho Jeon; Mikael Palner; Deju Ye; Adam Shuhendler; Frederick T Chin; Jianghong Rao

doi:10.1002/anie.201303422

Positron emission tomography imaging of drug-induced tumor apoptosis with a caspase-triggered nanoaggregation probe

Bin Shen, Jongho Jeon, Mikael Palner, Deju Ye, Adam Shuhendler, Frederick T Chin, Jianghong Rao

Stanford University

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Drug Design: An (18)F-labeled caspase-3-sensitive nanoaggregation positron emission tomography tracer was prepared and evaluated for imaging the caspase-3 activity in doxorubicin-treated tumor xenografts. Enhanced retention of the (18)F activity in apoptotic tumors is achieved through intramolecular macrocyclization and in situ aggregation upon caspase-3 activation (see picture).

Original language	English
Journal	Angewandte Chemie International Edition
Volume	52
Issue number	40
Pages (from-to)	10511-10514
ISSN	1433-7851
DOIs	https://doi.org/10.1002/anie.201303422
Publication status	Published - 27. Sept 2013
Externally published	Yes

Bibliographical note

Keywords

Animals
Apoptosis/drug effects
Benzothiazoles/chemistry
Caspase 3/metabolism
Diagnostic Imaging/methods
Fluorine Radioisotopes/chemistry
HeLa Cells
Heterografts
Humans
Mice
Molecular Structure
Nanostructures/chemistry
Neoplasms/diagnostic imaging
Oligopeptides/chemistry
Positron-Emission Tomography/methods
Radiopharmaceuticals

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10.1002/anie.201303422

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title = "Positron emission tomography imaging of drug-induced tumor apoptosis with a caspase-triggered nanoaggregation probe",

abstract = "Drug Design: An (18)F-labeled caspase-3-sensitive nanoaggregation positron emission tomography tracer was prepared and evaluated for imaging the caspase-3 activity in doxorubicin-treated tumor xenografts. Enhanced retention of the (18)F activity in apoptotic tumors is achieved through intramolecular macrocyclization and in situ aggregation upon caspase-3 activation (see picture).",

keywords = "Animals, Apoptosis/drug effects, Benzothiazoles/chemistry, Caspase 3/metabolism, Diagnostic Imaging/methods, Fluorine Radioisotopes/chemistry, HeLa Cells, Heterografts, Humans, Mice, Molecular Structure, Nanostructures/chemistry, Neoplasms/diagnostic imaging, Oligopeptides/chemistry, Positron-Emission Tomography/methods, Radiopharmaceuticals",

author = "Bin Shen and Jongho Jeon and Mikael Palner and Deju Ye and Adam Shuhendler and Chin, {Frederick T} and Jianghong Rao",

note = "Copyright {\textcopyright} 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",

year = "2013",

month = sep,

day = "27",

doi = "10.1002/anie.201303422",

language = "English",

volume = "52",

pages = "10511--10514",

journal = "Angewandte Chemie International Edition",

issn = "1433-7851",

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TY - JOUR

T1 - Positron emission tomography imaging of drug-induced tumor apoptosis with a caspase-triggered nanoaggregation probe

AU - Shen, Bin

AU - Jeon, Jongho

AU - Palner, Mikael

AU - Ye, Deju

AU - Shuhendler, Adam

AU - Chin, Frederick T

AU - Rao, Jianghong

PY - 2013/9/27

Y1 - 2013/9/27

N2 - Drug Design: An (18)F-labeled caspase-3-sensitive nanoaggregation positron emission tomography tracer was prepared and evaluated for imaging the caspase-3 activity in doxorubicin-treated tumor xenografts. Enhanced retention of the (18)F activity in apoptotic tumors is achieved through intramolecular macrocyclization and in situ aggregation upon caspase-3 activation (see picture).

AB - Drug Design: An (18)F-labeled caspase-3-sensitive nanoaggregation positron emission tomography tracer was prepared and evaluated for imaging the caspase-3 activity in doxorubicin-treated tumor xenografts. Enhanced retention of the (18)F activity in apoptotic tumors is achieved through intramolecular macrocyclization and in situ aggregation upon caspase-3 activation (see picture).

KW - Animals

KW - Apoptosis/drug effects

KW - Benzothiazoles/chemistry

KW - Caspase 3/metabolism

KW - Diagnostic Imaging/methods

KW - Fluorine Radioisotopes/chemistry

KW - HeLa Cells

KW - Heterografts

KW - Humans

KW - Mice

KW - Molecular Structure

KW - Nanostructures/chemistry

KW - Neoplasms/diagnostic imaging

KW - Oligopeptides/chemistry

KW - Positron-Emission Tomography/methods

KW - Radiopharmaceuticals

U2 - 10.1002/anie.201303422

DO - 10.1002/anie.201303422

M3 - Journal article

C2 - 23881906

SN - 1433-7851

VL - 52

SP - 10511

EP - 10514

JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

IS - 40

ER -

Positron emission tomography imaging of drug-induced tumor apoptosis with a caspase-triggered nanoaggregation probe

Abstract

Bibliographical note

Keywords

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