Polyphenols and Polyphenol-Derived Compounds From Plants and Contact Dermatitis

Lars Porskjær Christensen

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Abstract

Polyphenols and polyphenol-derived compounds from plants are common causes of skin reactions resulting in allergic contact dermatitis, photodermatitis, and/or irritant dermatitis. Allergic contact dermatitis is the most common skin reaction caused by plant products. Characteristic for many contact allergens is their ability to react with skin proteins in a Michael addition reaction, generating an antigen leading to an immunological response, that is, eczema. Most contact allergens of polyphenol origin are reactive quinones or polyphenols that are oxidized to quinones in the skin. Unlike allergenic substances, chemical irritants or phototoxic compounds will affect all subjects on the first exposure. Irritants typically result in a cutaneous inflammatory response, whereas phototoxic compounds lead to a bullous, erythematous eruption of the skin on light-exposed areas. Some polyphenols have antiinflammatory activity and/or can inhibit the activation and proliferation of T cells, thus being able to alleviate symptoms of skin inflammation and contact hypersensitivity.
Original languageEnglish
Title of host publicationPolyphenols : Prevention and Treatment of Human Disease
EditorsRonald Ross Watson, Victor R. Preedy, Sherma Zibadi
PublisherAcademic Press
Publication date2018
Edition2.
Pages349-384
Chapter29
ISBN (Print)9780128130087
DOIs
Publication statusPublished - 2018

Fingerprint

Contact Dermatitis
Skin
Quinones
Allergic Contact Dermatitis
Irritants
Allergens
Irritant Dermatitis
Photosensitivity Disorders
Eczema
Proteins

Cite this

Christensen, L. P. (2018). Polyphenols and Polyphenol-Derived Compounds From Plants and Contact Dermatitis. In R. R. Watson, V. R. Preedy, & S. Zibadi (Eds.), Polyphenols: Prevention and Treatment of Human Disease (2. ed., pp. 349-384). Academic Press. https://doi.org/10.1016/B978-0-12-813008-7.00029-1
Christensen, Lars Porskjær . / Polyphenols and Polyphenol-Derived Compounds From Plants and Contact Dermatitis. Polyphenols: Prevention and Treatment of Human Disease. editor / Ronald Ross Watson ; Victor R. Preedy ; Sherma Zibadi. 2. ed. Academic Press, 2018. pp. 349-384
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Christensen, LP 2018, Polyphenols and Polyphenol-Derived Compounds From Plants and Contact Dermatitis. in RR Watson, VR Preedy & S Zibadi (eds), Polyphenols: Prevention and Treatment of Human Disease. 2. edn, Academic Press, pp. 349-384. https://doi.org/10.1016/B978-0-12-813008-7.00029-1

Polyphenols and Polyphenol-Derived Compounds From Plants and Contact Dermatitis. / Christensen, Lars Porskjær .

Polyphenols: Prevention and Treatment of Human Disease. ed. / Ronald Ross Watson; Victor R. Preedy; Sherma Zibadi. 2. ed. Academic Press, 2018. p. 349-384.

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

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Christensen LP. Polyphenols and Polyphenol-Derived Compounds From Plants and Contact Dermatitis. In Watson RR, Preedy VR, Zibadi S, editors, Polyphenols: Prevention and Treatment of Human Disease. 2. ed. Academic Press. 2018. p. 349-384 https://doi.org/10.1016/B978-0-12-813008-7.00029-1