Poly(methylhydrosiloxane) as a green reducing agent in organophosphorus-catalysed amide bond formation

Daan F.J. Hamstra, Danny C. Lenstra, Tjeu J. Koenders, Floris P.J.T. Rutjes, Jasmin Mecinović*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review


Development of catalytic amide bond formation reactions has been the subject of the intensive investigations in the past decade. Herein we report an efficient organophosphorus-catalysed amidation reaction between unactivated carboxylic acids and amines. Poly(methylhydrosiloxane), a waste product of the silicon industry, is used as an inexpensive and green reducing agent for in situ reduction of phosphine oxide to phosphine. The reported method enables the synthesis of a wide range of secondary and tertiary amides in very good to excellent yields.

Original languageEnglish
JournalOrganic and Biomolecular Chemistry
Issue number30
Pages (from-to)6426-6432
Publication statusPublished - 1. Jan 2017
Externally publishedYes


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