Polymeric pH nanosensor with extended measurement range bearing octaarginine as cell penetrating peptide

Peng Ke; Honghao Sun; Mingxing Liu; Zhengding Su; Kanghong Hu; Hongda Zhua; Huilin Guo; Hongmei Sun; Lars Thomas Andresen; Lars Folke Olsen

doi:10.1049/iet-nbt.2014.0070

Polymeric pH nanosensor with extended measurement range bearing octaarginine as cell penetrating peptide

Peng Ke, Honghao Sun, Mingxing Liu, Zhengding Su, Kanghong Hu, Hongda Zhua, Huilin Guo, Hongmei Sun, Lars Thomas Andresen, Lars Folke Olsen

Department of Biochemistry and Molecular Biology

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

A synthetic peptide octaarginine which mimics human immunodeficiency virus-1, Tat protein is used as cell penetrating moiety for new pH nanosensors which demonstrate enhanced cellular uptake and expanded measurement range from pH 3.9 to pH 7.3 by simultaneously incorporating two complemental pH-sensitive fluorophores in a same nanoparticle. The authors believe that this triple fluorescent pH sensor provides a new tool to pH measurements that can have application in cellular uptake mechanism study and new nanomedicine design.

Original language	English
Journal	IET Nanobiotechnology
Volume	10
Issue number	1
Pages (from-to)	8-12
ISSN	1751-8741
DOIs	https://doi.org/10.1049/iet-nbt.2014.0070
Publication status	Published - Feb 2016

Keywords

Biosensing Techniques/methods
Cell-Penetrating Peptides/chemistry
Fluorescent Dyes/chemistry
HeLa Cells
Humans
Hydrogen-Ion Concentration
Oligopeptides/chemistry

Documents & Links

10.1049/iet-nbt.2014.0070

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title = "Polymeric pH nanosensor with extended measurement range bearing octaarginine as cell penetrating peptide",

abstract = "A synthetic peptide octaarginine which mimics human immunodeficiency virus-1, Tat protein is used as cell penetrating moiety for new pH nanosensors which demonstrate enhanced cellular uptake and expanded measurement range from pH 3.9 to pH 7.3 by simultaneously incorporating two complemental pH-sensitive fluorophores in a same nanoparticle. The authors believe that this triple fluorescent pH sensor provides a new tool to pH measurements that can have application in cellular uptake mechanism study and new nanomedicine design.",

keywords = "Biosensing Techniques/methods, Cell-Penetrating Peptides/chemistry, Fluorescent Dyes/chemistry, HeLa Cells, Humans, Hydrogen-Ion Concentration, Oligopeptides/chemistry",

author = "Peng Ke and Honghao Sun and Mingxing Liu and Zhengding Su and Kanghong Hu and Hongda Zhua and Huilin Guo and Hongmei Sun and Andresen, {Lars Thomas} and Olsen, {Lars Folke}",

year = "2016",

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doi = "10.1049/iet-nbt.2014.0070",

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AU - Ke, Peng

AU - Sun, Honghao

AU - Liu, Mingxing

AU - Su, Zhengding

AU - Hu, Kanghong

AU - Zhua, Hongda

AU - Guo, Huilin

AU - Sun, Hongmei

AU - Andresen, Lars Thomas

AU - Olsen, Lars Folke

PY - 2016/2

Y1 - 2016/2

N2 - A synthetic peptide octaarginine which mimics human immunodeficiency virus-1, Tat protein is used as cell penetrating moiety for new pH nanosensors which demonstrate enhanced cellular uptake and expanded measurement range from pH 3.9 to pH 7.3 by simultaneously incorporating two complemental pH-sensitive fluorophores in a same nanoparticle. The authors believe that this triple fluorescent pH sensor provides a new tool to pH measurements that can have application in cellular uptake mechanism study and new nanomedicine design.

AB - A synthetic peptide octaarginine which mimics human immunodeficiency virus-1, Tat protein is used as cell penetrating moiety for new pH nanosensors which demonstrate enhanced cellular uptake and expanded measurement range from pH 3.9 to pH 7.3 by simultaneously incorporating two complemental pH-sensitive fluorophores in a same nanoparticle. The authors believe that this triple fluorescent pH sensor provides a new tool to pH measurements that can have application in cellular uptake mechanism study and new nanomedicine design.

KW - Biosensing Techniques/methods

KW - Cell-Penetrating Peptides/chemistry

KW - Fluorescent Dyes/chemistry

KW - HeLa Cells

KW - Humans

KW - Hydrogen-Ion Concentration

KW - Oligopeptides/chemistry

U2 - 10.1049/iet-nbt.2014.0070

DO - 10.1049/iet-nbt.2014.0070

M3 - Journal article

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SN - 1751-8741

VL - 10

SP - 8

EP - 12

JO - IET Nanobiotechnology

JF - IET Nanobiotechnology

IS - 1

ER -

Polymeric pH nanosensor with extended measurement range bearing octaarginine as cell penetrating peptide

Abstract

Keywords

Documents & Links

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