TY - JOUR
T1 - Plasma proteomics to identify biomarkers - Application to cardiovascular diseases
AU - Beck, Hans Christian
AU - Overgaard, Martin
AU - Melholt Rasmussen, Lars
PY - 2015/6/1
Y1 - 2015/6/1
N2 - There is an unmet need for new cardiovascular biomarkers. Despite this only few biomarkers for the diagnosis or screening of cardiovascular diseases have been implemented in the clinic. Thousands of proteins can be analysed in plasma by mass spectrometry-based proteomics technologies. Therefore, this technology may therefore identify new biomarkers that previously have not been associated with cardiovascular diseases. In this review, we summarize the key challenges and considerations, including strategies, recent discoveries and clinical applications in cardiovascular proteomics that may lead to the discovery of novel cardiovascular biomarkers.
AB - There is an unmet need for new cardiovascular biomarkers. Despite this only few biomarkers for the diagnosis or screening of cardiovascular diseases have been implemented in the clinic. Thousands of proteins can be analysed in plasma by mass spectrometry-based proteomics technologies. Therefore, this technology may therefore identify new biomarkers that previously have not been associated with cardiovascular diseases. In this review, we summarize the key challenges and considerations, including strategies, recent discoveries and clinical applications in cardiovascular proteomics that may lead to the discovery of novel cardiovascular biomarkers.
KW - Cardiovascular disease
KW - Plasma
KW - Protein biomarkers
KW - Proteomics
U2 - 10.1016/j.trprot.2015.01.001
DO - 10.1016/j.trprot.2015.01.001
M3 - Journal article
SN - 2212-9634
VL - 7
SP - 40
EP - 48
JO - Translational Proteomics
JF - Translational Proteomics
IS - June
ER -