Phytochemicals in cancer and their effect on the PI3K/AKT-mediated cellular signalling

Olaf-Georg Issinger*, Barbara Guerra*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Protein kinases belong to the largest family of enzymes controlling every aspect of cellular activity including gene expression, cell division, differentiation and metabolism. They are part of major intracellular signalling pathways. Hence, it is not surprising that they are involved in the development of major diseases such as cardiovascular disorders, diabetes, dementia and, most importantly, cancer when they undergo mutations, modifications and unbalanced expression.

This review will explore the possibility to draw a connection between the application of natural phytochemicals and the treatment of cancer. We have chosen to focus on the PI3K/AKT cellular signalling pathway which has been shown to be a major target by natural compounds in cell cultures and animal models.
Original languageEnglish
Article number111650
JournalBiomedicine & Pharmacotherapy
Volume139
Number of pages11
ISSN0753-3322
DOIs
Publication statusPublished - Jul 2021

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