Physicochemical Properties of Drugs for Use in the Pharmaceutical Industry

René Holm

doi:10.1007/978-3-030-73317-9_111-1

Physicochemical Properties of Drugs for Use in the Pharmaceutical Industry

Research output: Chapter in Book/Report/Conference proceeding › Encyclopedia chapter › Research › peer-review

Abstract

This chapter provides a description of the three central elements in the physicochemical characterization of drug compounds, i.e., the acid dissociation constant, log P, and solubility, and the associated experiment to determine the solid form, in particular, for the latter property. The description of the different properties includes both a description of the concrete property and a short explanation of its importance and a description of the main experimental methods to determine the parameter under discussion. The designated three main properties are selected, as these are highly important in order to understand the druggability of a novel compound; hence, they are important optimization parameters for a novel compound.

Original language	English
Title of host publication	Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays
Editors	Franz J. Hock, Michael K. Pugsley
Publisher	Springer
Publication date	2023
Pages	1-43
ISBN (Print)	978-3-030-73317-9
ISBN (Electronic)	978-3-030-73317-9
DOIs	https://doi.org/10.1007/978-3-030-73317-9_111-1
Publication status	Published - 2023

Documents & Links

10.1007/978-3-030-73317-9_111-1

Cite this

@inbook{d74005938f174b8fb06f04072a7e45fe,

title = "Physicochemical Properties of Drugs for Use in the Pharmaceutical Industry",

abstract = "This chapter provides a description of the three central elements in the physicochemical characterization of drug compounds, i.e., the acid dissociation constant, log P, and solubility, and the associated experiment to determine the solid form, in particular, for the latter property. The description of the different properties includes both a description of the concrete property and a short explanation of its importance and a description of the main experimental methods to determine the parameter under discussion. The designated three main properties are selected, as these are highly important in order to understand the druggability of a novel compound; hence, they are important optimization parameters for a novel compound.",

author = "Ren{\'e} Holm",

year = "2023",

doi = "10.1007/978-3-030-73317-9_111-1",

language = "English",

isbn = "978-3-030-73317-9",

pages = "1--43",

editor = "Hock, {Franz J.} and Pugsley, {Michael K.}",

booktitle = "Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays",

publisher = "Springer",

address = "Germany",

}

TY - ENCYC

T1 - Physicochemical Properties of Drugs for Use in the Pharmaceutical Industry

AU - Holm, René

PY - 2023

Y1 - 2023

N2 - This chapter provides a description of the three central elements in the physicochemical characterization of drug compounds, i.e., the acid dissociation constant, log P, and solubility, and the associated experiment to determine the solid form, in particular, for the latter property. The description of the different properties includes both a description of the concrete property and a short explanation of its importance and a description of the main experimental methods to determine the parameter under discussion. The designated three main properties are selected, as these are highly important in order to understand the druggability of a novel compound; hence, they are important optimization parameters for a novel compound.

AB - This chapter provides a description of the three central elements in the physicochemical characterization of drug compounds, i.e., the acid dissociation constant, log P, and solubility, and the associated experiment to determine the solid form, in particular, for the latter property. The description of the different properties includes both a description of the concrete property and a short explanation of its importance and a description of the main experimental methods to determine the parameter under discussion. The designated three main properties are selected, as these are highly important in order to understand the druggability of a novel compound; hence, they are important optimization parameters for a novel compound.

U2 - 10.1007/978-3-030-73317-9_111-1

DO - 10.1007/978-3-030-73317-9_111-1

M3 - Encyclopedia chapter

SN - 978-3-030-73317-9

SP - 1

EP - 43

BT - Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays

A2 - Hock, Franz J.

A2 - Pugsley, Michael K.

PB - Springer

ER -