Peritoneal microdialysis as a tool for detecting anastomotic leakage in patients after left-side colon and rectal resection. A systematic review

Mark Bremholm Ellebaeka, Freek Daams, Kjell Jansson, Peter Matthiessen, Cyril Cosse, Claus Fristrup, Signe Bremholm Ellebaek, Jonas Emil Sabroe, Niels Qvist

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Objective: The objective was to evaluate peritoneal microdialysis in the detection of clinical anastomotic leakage after left-sided colon and rectal resection through a systematic review. Methods: A systematic review (PRISMA guidelines) based on a systematic search through PubMed, Cochrane Library, and EMBASE (1 February 2017) was performed. Methodological index of non-randomised studies score was selected to assess the methodological quality. Patient demographics and raw data for intraperitoneal microdialysis concentrations of glucose, lactate, glycerol and pyruvate for 5 d postoperative were obtained from the respective study groups. Results: Ten studies with a total of 128 patients were included. Thirty (23 patients developed clinical anastomotic leakage. The area under the curve for intraperitoneal lactate concentration was significant higher in patients with anastomotic leakage (58.2; 95% CI 39.2, 77.2) compared with the no leakage group (41.0; 95% CI 35.2, 46.1; p = .007). Receiver operating characteristic curve analysis of the maximum measured lactate concentration demonstrated 25% sensitivity, 88% specificity and 74% accuracy for AL at a cut-off value of 9.8 mmol/L. The odds ratio for a 5 mmol/L increase in lactate in relation to the risk of AL was 2.9 (CI 1.1, 8.0). Conclusions: Increased intraperitoneal lactate concentration within the first 5 d postoperative was significantly associated with clinical anastomotic leakage, but with low predictive values. The microdialysis method is not yet ready for clinical implication before large prospective studies have defined cut off values for a biologic marker in the setting of a clear definitions of leakage.
    Original languageEnglish
    Book seriesScandinavian Journal of Gastroenterology
    Volume53
    Issue number12
    Pages (from-to)1625-1632
    ISSN0036-5521
    DOIs
    Publication statusPublished - 2. Dec 2018

    Keywords

    • Peritoneal microdialysis
    • anastomotic leakage
    • colorectal resection
    • lactate

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