Peripheral nerve injury causes transient expression of MHC class I antigens in rat motor neurons and skeletal muscles

J Maehlen, I Nennesmo, A B Olsson, T Olsson, H D Schröder, K Kristensson

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

After a peripheral nerve lesion (rat facial and sciatic) an induction of major histocompatibility complex (MHC) antigens class I was detected immunohistochemically in skeletal muscle fibers and motor neurons. This MHC expression was transient after a nerve crush, when regeneration occurred, but persisted after a nerve cut, when regeneration was prevented. Since the time course of MHC class I expression correlates to that of regeneration a role for this cell surface molecule in regeneration may be considered.

Original languageEnglish
JournalBrain Research
Volume481
Issue number2
Pages (from-to)368-72
Number of pages5
ISSN0006-8993
Publication statusPublished - 6. Mar 1989

Fingerprint

Peripheral Nerve Injuries
Motor Neurons
Skeletal Muscle
Nerve Crush
Peripheral Nerves

Keywords

  • Animals
  • Histocompatibility Antigens Class I
  • Male
  • Motor Neurons
  • Muscles
  • Nerve Regeneration
  • Peripheral Nerve Injuries
  • Rats
  • Rats, Inbred Strains
  • Time Factors
  • Journal Article
  • Research Support, Non-U.S. Gov't

Cite this

Maehlen, J., Nennesmo, I., Olsson, A. B., Olsson, T., Schröder, H. D., & Kristensson, K. (1989). Peripheral nerve injury causes transient expression of MHC class I antigens in rat motor neurons and skeletal muscles. Brain Research, 481(2), 368-72.
Maehlen, J ; Nennesmo, I ; Olsson, A B ; Olsson, T ; Schröder, H D ; Kristensson, K. / Peripheral nerve injury causes transient expression of MHC class I antigens in rat motor neurons and skeletal muscles. In: Brain Research. 1989 ; Vol. 481, No. 2. pp. 368-72.
@article{ad6ba79f5b554f3385a4f547dc72780e,
title = "Peripheral nerve injury causes transient expression of MHC class I antigens in rat motor neurons and skeletal muscles",
abstract = "After a peripheral nerve lesion (rat facial and sciatic) an induction of major histocompatibility complex (MHC) antigens class I was detected immunohistochemically in skeletal muscle fibers and motor neurons. This MHC expression was transient after a nerve crush, when regeneration occurred, but persisted after a nerve cut, when regeneration was prevented. Since the time course of MHC class I expression correlates to that of regeneration a role for this cell surface molecule in regeneration may be considered.",
keywords = "Animals, Histocompatibility Antigens Class I, Male, Motor Neurons, Muscles, Nerve Regeneration, Peripheral Nerve Injuries, Rats, Rats, Inbred Strains, Time Factors, Journal Article, Research Support, Non-U.S. Gov't",
author = "J Maehlen and I Nennesmo and Olsson, {A B} and T Olsson and Schr{\"o}der, {H D} and K Kristensson",
year = "1989",
month = "3",
day = "6",
language = "English",
volume = "481",
pages = "368--72",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "2",

}

Maehlen, J, Nennesmo, I, Olsson, AB, Olsson, T, Schröder, HD & Kristensson, K 1989, 'Peripheral nerve injury causes transient expression of MHC class I antigens in rat motor neurons and skeletal muscles', Brain Research, vol. 481, no. 2, pp. 368-72.

Peripheral nerve injury causes transient expression of MHC class I antigens in rat motor neurons and skeletal muscles. / Maehlen, J; Nennesmo, I; Olsson, A B; Olsson, T; Schröder, H D; Kristensson, K.

In: Brain Research, Vol. 481, No. 2, 06.03.1989, p. 368-72.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Peripheral nerve injury causes transient expression of MHC class I antigens in rat motor neurons and skeletal muscles

AU - Maehlen, J

AU - Nennesmo, I

AU - Olsson, A B

AU - Olsson, T

AU - Schröder, H D

AU - Kristensson, K

PY - 1989/3/6

Y1 - 1989/3/6

N2 - After a peripheral nerve lesion (rat facial and sciatic) an induction of major histocompatibility complex (MHC) antigens class I was detected immunohistochemically in skeletal muscle fibers and motor neurons. This MHC expression was transient after a nerve crush, when regeneration occurred, but persisted after a nerve cut, when regeneration was prevented. Since the time course of MHC class I expression correlates to that of regeneration a role for this cell surface molecule in regeneration may be considered.

AB - After a peripheral nerve lesion (rat facial and sciatic) an induction of major histocompatibility complex (MHC) antigens class I was detected immunohistochemically in skeletal muscle fibers and motor neurons. This MHC expression was transient after a nerve crush, when regeneration occurred, but persisted after a nerve cut, when regeneration was prevented. Since the time course of MHC class I expression correlates to that of regeneration a role for this cell surface molecule in regeneration may be considered.

KW - Animals

KW - Histocompatibility Antigens Class I

KW - Male

KW - Motor Neurons

KW - Muscles

KW - Nerve Regeneration

KW - Peripheral Nerve Injuries

KW - Rats

KW - Rats, Inbred Strains

KW - Time Factors

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

M3 - Journal article

VL - 481

SP - 368

EP - 372

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 2

ER -