Abstract
Meta-analyses of cohort studies and a recent randomized, placebo-controlled study have shown that perioperative bridging of warfarin therapy with therapeutic doses of heparin results in a multi-fold increase in major bleeding but no reduction in the incidence of thromboembolism. It is time to reconsider heparin bridging: When is heparin bridging superfluous? When is prophylactic dosage indicated? And when is it safe to use therapeutic dosing?
| Translated title of the contribution | Perioperative heparin bridging is rarely indicated |
|---|---|
| Original language | Danish |
| Article number | V12150952 |
| Journal | Ugeskrift for Laeger |
| Volume | 178 |
| Issue number | 12 |
| ISSN | 0041-5782 |
| Publication status | Published - 2016 |
| Externally published | Yes |