Perfluoroalkyl and polyfluoroalkyl substances and human fetal growth: A systematic review

Cathrine Carlsen Bach, Bodil Hammer Bech, Nis Brix Lauridsen, Ellen Aagaard Nohr, Jens Peter Ellekilde Bonde, Tine Brink Henriksen

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Abstract

Background: Exposure to perfluoroalkyl and polyfluoroalkyl substances (PFASs) is ubiquitous in most regions of the world. The most commonly studied PFASs are perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA). Animal studies indicate that maternal PFAS exposure is associated with reduced fetal growth. However, the results of human studies are inconsistent. Objectives: To summarize the evidence of an association between exposure to PFASs, particularly PFOS and PFOA, and human fetal growth. Methods: Systematic literature searches were performed in MEDLINE and EMBASE. We included original studies on pregnant women with measurements of PFOA or PFOS in maternal blood during pregnancy or the umbilical cord and associations with birth weight or related outcomes according to the PFAS level. Citations and references from the included articles were investigated to locate more relevant articles. Study characteristics and results were extracted to structured tables. The completeness of reporting as well as the risk of bias and confounding were assessed. Results: Fourteen studies were eligible. In utero PFOA exposure was associated with decreased measures of continuous birth weight in all studies, even though the magnitude of the association differed and many results were statistically insignificant. PFOS exposure and birth weight were associated in some studies, while others found no association. Conclusions: Higher PFOS and PFOA concentrations were associated with decreased average birth weight in most studies, but only some results were statistically significant. The impact on public health is unclear, but the global exposure to PFASs warrants further investigation.

Original languageEnglish
Publication date2014
Publication statusPublished - 2014
EventAnnual Meeting in the European Academy of Pediatric Societies - Barcelona, Spain
Duration: 17. Oct 201421. Oct 2014

Conference

ConferenceAnnual Meeting in the European Academy of Pediatric Societies
CountrySpain
CityBarcelona
Period17/10/201421/10/2014

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perfluorooctanoic acid
Mothers
Umbilical Cord
MEDLINE
Pregnant Women
Public Health
perfluorooctane sulfonic acid

Cite this

Bach, C. C., Bech, B. H., Brix Lauridsen, N., Nohr, E. A., Bonde, J. P. E., & Henriksen, T. B. (2014). Perfluoroalkyl and polyfluoroalkyl substances and human fetal growth: A systematic review. Poster session presented at Annual Meeting in the European Academy of Pediatric Societies, Barcelona, Spain.
Bach, Cathrine Carlsen ; Bech, Bodil Hammer ; Brix Lauridsen, Nis ; Nohr, Ellen Aagaard ; Bonde, Jens Peter Ellekilde ; Henriksen, Tine Brink. / Perfluoroalkyl and polyfluoroalkyl substances and human fetal growth : A systematic review. Poster session presented at Annual Meeting in the European Academy of Pediatric Societies, Barcelona, Spain.
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abstract = "Background: Exposure to perfluoroalkyl and polyfluoroalkyl substances (PFASs) is ubiquitous in most regions of the world. The most commonly studied PFASs are perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA). Animal studies indicate that maternal PFAS exposure is associated with reduced fetal growth. However, the results of human studies are inconsistent. Objectives: To summarize the evidence of an association between exposure to PFASs, particularly PFOS and PFOA, and human fetal growth. Methods: Systematic literature searches were performed in MEDLINE and EMBASE. We included original studies on pregnant women with measurements of PFOA or PFOS in maternal blood during pregnancy or the umbilical cord and associations with birth weight or related outcomes according to the PFAS level. Citations and references from the included articles were investigated to locate more relevant articles. Study characteristics and results were extracted to structured tables. The completeness of reporting as well as the risk of bias and confounding were assessed. Results: Fourteen studies were eligible. In utero PFOA exposure was associated with decreased measures of continuous birth weight in all studies, even though the magnitude of the association differed and many results were statistically insignificant. PFOS exposure and birth weight were associated in some studies, while others found no association. Conclusions: Higher PFOS and PFOA concentrations were associated with decreased average birth weight in most studies, but only some results were statistically significant. The impact on public health is unclear, but the global exposure to PFASs warrants further investigation.",
author = "Bach, {Cathrine Carlsen} and Bech, {Bodil Hammer} and {Brix Lauridsen}, Nis and Nohr, {Ellen Aagaard} and Bonde, {Jens Peter Ellekilde} and Henriksen, {Tine Brink}",
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Bach, CC, Bech, BH, Brix Lauridsen, N, Nohr, EA, Bonde, JPE & Henriksen, TB 2014, 'Perfluoroalkyl and polyfluoroalkyl substances and human fetal growth: A systematic review', Annual Meeting in the European Academy of Pediatric Societies, Barcelona, Spain, 17/10/2014 - 21/10/2014.

Perfluoroalkyl and polyfluoroalkyl substances and human fetal growth : A systematic review. / Bach, Cathrine Carlsen; Bech, Bodil Hammer; Brix Lauridsen, Nis; Nohr, Ellen Aagaard; Bonde, Jens Peter Ellekilde; Henriksen, Tine Brink.

2014. Poster session presented at Annual Meeting in the European Academy of Pediatric Societies, Barcelona, Spain.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

TY - CONF

T1 - Perfluoroalkyl and polyfluoroalkyl substances and human fetal growth

T2 - A systematic review

AU - Bach, Cathrine Carlsen

AU - Bech, Bodil Hammer

AU - Brix Lauridsen, Nis

AU - Nohr, Ellen Aagaard

AU - Bonde, Jens Peter Ellekilde

AU - Henriksen, Tine Brink

PY - 2014

Y1 - 2014

N2 - Background: Exposure to perfluoroalkyl and polyfluoroalkyl substances (PFASs) is ubiquitous in most regions of the world. The most commonly studied PFASs are perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA). Animal studies indicate that maternal PFAS exposure is associated with reduced fetal growth. However, the results of human studies are inconsistent. Objectives: To summarize the evidence of an association between exposure to PFASs, particularly PFOS and PFOA, and human fetal growth. Methods: Systematic literature searches were performed in MEDLINE and EMBASE. We included original studies on pregnant women with measurements of PFOA or PFOS in maternal blood during pregnancy or the umbilical cord and associations with birth weight or related outcomes according to the PFAS level. Citations and references from the included articles were investigated to locate more relevant articles. Study characteristics and results were extracted to structured tables. The completeness of reporting as well as the risk of bias and confounding were assessed. Results: Fourteen studies were eligible. In utero PFOA exposure was associated with decreased measures of continuous birth weight in all studies, even though the magnitude of the association differed and many results were statistically insignificant. PFOS exposure and birth weight were associated in some studies, while others found no association. Conclusions: Higher PFOS and PFOA concentrations were associated with decreased average birth weight in most studies, but only some results were statistically significant. The impact on public health is unclear, but the global exposure to PFASs warrants further investigation.

AB - Background: Exposure to perfluoroalkyl and polyfluoroalkyl substances (PFASs) is ubiquitous in most regions of the world. The most commonly studied PFASs are perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA). Animal studies indicate that maternal PFAS exposure is associated with reduced fetal growth. However, the results of human studies are inconsistent. Objectives: To summarize the evidence of an association between exposure to PFASs, particularly PFOS and PFOA, and human fetal growth. Methods: Systematic literature searches were performed in MEDLINE and EMBASE. We included original studies on pregnant women with measurements of PFOA or PFOS in maternal blood during pregnancy or the umbilical cord and associations with birth weight or related outcomes according to the PFAS level. Citations and references from the included articles were investigated to locate more relevant articles. Study characteristics and results were extracted to structured tables. The completeness of reporting as well as the risk of bias and confounding were assessed. Results: Fourteen studies were eligible. In utero PFOA exposure was associated with decreased measures of continuous birth weight in all studies, even though the magnitude of the association differed and many results were statistically insignificant. PFOS exposure and birth weight were associated in some studies, while others found no association. Conclusions: Higher PFOS and PFOA concentrations were associated with decreased average birth weight in most studies, but only some results were statistically significant. The impact on public health is unclear, but the global exposure to PFASs warrants further investigation.

M3 - Poster

ER -

Bach CC, Bech BH, Brix Lauridsen N, Nohr EA, Bonde JPE, Henriksen TB. Perfluoroalkyl and polyfluoroalkyl substances and human fetal growth: A systematic review. 2014. Poster session presented at Annual Meeting in the European Academy of Pediatric Societies, Barcelona, Spain.