Pediatric Expression of Mast Cell Activation Disorders

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Abstract

Mast cell activation disorders is a term proposed to cover diseases and conditions related to activation of mast cells and effects of mast cell mediators. In its broadest sense, the term encompasses a wide range of diseases from allergic asthma to rhinoconjunctivitis, urticaria, food allergy, anaphylaxis, mastocytosis, and other conditions where MC activation is contributing to the pathogenesis. This article focuses on clinical presentations, challenges, and controversies in pediatric mastocytosis and gives an overview of current knowledge and areas in need of further research.

Original languageEnglish
JournalImmunology and Allergy Clinics of North America
Volume38
Issue number3
Pages (from-to)365-377
ISSN0889-8561
DOIs
Publication statusPublished - Aug 2018

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Mast Cells
Mastocytosis
Pediatrics
Food Hypersensitivity
Urticaria
Research

Keywords

  • Anaphylaxis
  • KIT mutations
  • Mast cell activation
  • Mast cell activation disorders
  • Mastocytosis
  • Tryptase
  • Urticaria pigmentosa
  • Urticaria/genetics
  • Cell Degranulation
  • Humans
  • Proto-Oncogene Proteins c-kit/genetics
  • Mastocytosis/genetics
  • Mast Cells/physiology
  • Tryptases/metabolism
  • Anaphylaxis/genetics
  • Adult
  • Child

Cite this

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title = "Pediatric Expression of Mast Cell Activation Disorders",
abstract = "Mast cell activation disorders is a term proposed to cover diseases and conditions related to activation of mast cells and effects of mast cell mediators. In its broadest sense, the term encompasses a wide range of diseases from allergic asthma to rhinoconjunctivitis, urticaria, food allergy, anaphylaxis, mastocytosis, and other conditions where MC activation is contributing to the pathogenesis. This article focuses on clinical presentations, challenges, and controversies in pediatric mastocytosis and gives an overview of current knowledge and areas in need of further research.",
keywords = "Anaphylaxis, KIT mutations, Mast cell activation, Mast cell activation disorders, Mastocytosis, Tryptase, Urticaria pigmentosa, Urticaria/genetics, Cell Degranulation, Humans, Proto-Oncogene Proteins c-kit/genetics, Mastocytosis/genetics, Mast Cells/physiology, Tryptases/metabolism, Anaphylaxis/genetics, Adult, Child",
author = "Sigurd Broesby-Olsen and Melody Carter and Kjaer, {Henrik Fomsgaard} and Mortz, {Charlotte Gotthard} and M{\o}ller, {Michael Boe} and Kristensen, {Thomas Kielsgaard} and Carsten Bindslev-Jensen and Lone Agertoft",
year = "2018",
month = "8",
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language = "English",
volume = "38",
pages = "365--377",
journal = "Immunology and Allergy Clinics of North America",
issn = "0889-8561",
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TY - JOUR

T1 - Pediatric Expression of Mast Cell Activation Disorders

AU - Broesby-Olsen, Sigurd

AU - Carter, Melody

AU - Kjaer, Henrik Fomsgaard

AU - Mortz, Charlotte Gotthard

AU - Møller, Michael Boe

AU - Kristensen, Thomas Kielsgaard

AU - Bindslev-Jensen, Carsten

AU - Agertoft, Lone

PY - 2018/8

Y1 - 2018/8

N2 - Mast cell activation disorders is a term proposed to cover diseases and conditions related to activation of mast cells and effects of mast cell mediators. In its broadest sense, the term encompasses a wide range of diseases from allergic asthma to rhinoconjunctivitis, urticaria, food allergy, anaphylaxis, mastocytosis, and other conditions where MC activation is contributing to the pathogenesis. This article focuses on clinical presentations, challenges, and controversies in pediatric mastocytosis and gives an overview of current knowledge and areas in need of further research.

AB - Mast cell activation disorders is a term proposed to cover diseases and conditions related to activation of mast cells and effects of mast cell mediators. In its broadest sense, the term encompasses a wide range of diseases from allergic asthma to rhinoconjunctivitis, urticaria, food allergy, anaphylaxis, mastocytosis, and other conditions where MC activation is contributing to the pathogenesis. This article focuses on clinical presentations, challenges, and controversies in pediatric mastocytosis and gives an overview of current knowledge and areas in need of further research.

KW - Anaphylaxis

KW - KIT mutations

KW - Mast cell activation

KW - Mast cell activation disorders

KW - Mastocytosis

KW - Tryptase

KW - Urticaria pigmentosa

KW - Urticaria/genetics

KW - Cell Degranulation

KW - Humans

KW - Proto-Oncogene Proteins c-kit/genetics

KW - Mastocytosis/genetics

KW - Mast Cells/physiology

KW - Tryptases/metabolism

KW - Anaphylaxis/genetics

KW - Adult

KW - Child

U2 - 10.1016/j.iac.2018.04.009

DO - 10.1016/j.iac.2018.04.009

M3 - Journal article

C2 - 30007457

AN - SCOPUS:85047077986

VL - 38

SP - 365

EP - 377

JO - Immunology and Allergy Clinics of North America

JF - Immunology and Allergy Clinics of North America

SN - 0889-8561

IS - 3

ER -